Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   IB936_RS00270 Genome accession   NZ_CP061133
Coordinates   48349..49260 (+) Length   303 a.a.
NCBI ID   WP_011528143.1    Uniprot ID   A0A660A660
Organism   Streptococcus pyogenes strain BSAC_bs472 isolate Invasive disease     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 43349..54260
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IB936_RS00255 (IB936_00255) - 44004..45539 (+) 1536 WP_021299446.1 AAA family ATPase -
  IB936_RS00260 (IB936_00260) - 45532..46416 (+) 885 WP_011528141.1 HNH endonuclease -
  IB936_RS00265 (IB936_00265) purB 46925..48217 (+) 1293 WP_011528142.1 adenylosuccinate lyase -
  IB936_RS00270 (IB936_00270) comR 48349..49260 (+) 912 WP_011528143.1 transcriptional regulator Rgg4/ComR Regulator
  IB936_RS09435 comS 49344..49439 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  IB936_RS00275 (IB936_00275) ruvB 49486..50484 (+) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  IB936_RS00280 (IB936_00280) - 50622..51059 (+) 438 WP_002987727.1 low molecular weight protein-tyrosine-phosphatase -
  IB936_RS00285 (IB936_00285) - 51083..51484 (+) 402 WP_002986671.1 MORN repeat-containing protein -
  IB936_RS00290 (IB936_00290) - 51481..53256 (+) 1776 WP_011528145.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35743.25 Da        Isoelectric Point: 4.4858

>NTDB_id=480900 IB936_RS00270 WP_011528143.1 48349..49260(+) (comR) [Streptococcus pyogenes strain BSAC_bs472 isolate Invasive disease]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDVIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=480900 IB936_RS00270 WP_011528143.1 48349..49260(+) (comR) [Streptococcus pyogenes strain BSAC_bs472 isolate Invasive disease]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGAATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTGTCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATGTAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

ComR tetratricopeptide (ComR_TPR)

(73-296)

Helix-turn-helix (HTH_3)

(12-64)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A660

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

99.67

100

0.997
  comR Streptococcus pyogenes MGAS315

58.14

99.34

0.578
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462