Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   IB937_RS08355 Genome accession   NZ_CP061132
Coordinates   1631488..1632174 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1626488..1637174
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IB937_RS08335 (IB937_08335) dnaI 1627210..1628112 (-) 903 WP_011528269.1 primosomal protein DnaI -
  IB937_RS08340 (IB937_08340) - 1628113..1629288 (-) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  IB937_RS08345 (IB937_08345) nrdR 1629272..1629766 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  IB937_RS08350 (IB937_08350) covS 1629981..1631482 (-) 1502 Protein_1603 two-component system sensor histidine kinase CovS -
  IB937_RS08355 (IB937_08355) covR 1631488..1632174 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  IB937_RS08360 (IB937_08360) - 1632441..1632974 (-) 534 WP_011054200.1 YceD family protein -
  IB937_RS08365 (IB937_08365) htpX 1633208..1634104 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  IB937_RS08370 (IB937_08370) - 1634151..1634708 (-) 558 WP_002985956.1 LemA family protein -
  IB937_RS08375 (IB937_08375) rsmG 1634858..1635571 (+) 714 WP_011528267.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  IB937_RS08380 (IB937_08380) ktrB 1635655..1637031 (+) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=480890 IB937_RS08355 WP_002991052.1 1631488..1632174(-) (covR) [Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=480890 IB937_RS08355 WP_002991052.1 1631488..1632174(-) (covR) [Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACATATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGACATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425