Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   IB938_RS01555 Genome accession   NZ_CP061131
Coordinates   291435..292121 (+) Length   228 a.a.
NCBI ID   WP_187830488.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 286435..297121
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IB938_RS01530 (IB938_01530) ktrB 286578..287954 (-) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -
  IB938_RS01535 (IB938_01535) rsmG 288038..288751 (-) 714 WP_011528267.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  IB938_RS01540 (IB938_01540) - 288901..289458 (+) 558 WP_002985956.1 LemA family protein -
  IB938_RS01545 (IB938_01545) htpX 289505..290401 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  IB938_RS01550 (IB938_01550) - 290635..291168 (+) 534 WP_011054200.1 YceD family protein -
  IB938_RS01555 (IB938_01555) covR 291435..292121 (+) 687 WP_187830488.1 two-component system response regulator CovR Regulator
  IB938_RS01560 (IB938_01560) covS 292127..293629 (+) 1503 WP_002985946.1 two-component system sensor histidine kinase CovS -
  IB938_RS01565 (IB938_01565) nrdR 293844..294338 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  IB938_RS01570 (IB938_01570) - 294322..295497 (+) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  IB938_RS01575 (IB938_01575) dnaI 295498..296400 (+) 903 WP_011528269.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26676.73 Da        Isoelectric Point: 4.6047

>NTDB_id=480806 IB938_RS01555 WP_187830488.1 291435..292121(+) (covR) [Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVADLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=480806 IB938_RS01555 WP_187830488.1 291435..292121(+) (covR) [Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACATATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGATTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGACATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.659

100

0.82
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.52

99.561

0.662
  vicR Streptococcus mutans UA159

43.534

100

0.443
  micA Streptococcus pneumoniae Cp1015

41.739

100

0.421