Detailed information NTG0477282

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: H7790_RS00515
• Genome accession: NZ_CP060645
• Coordinates: 87929..88840 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain TSPY1349
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 82929..93840

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7790_RS00480 (H7790_00485)	purE	83092..83583 (+)	492	WP_032460539.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
H7790_RS00485 (H7790_00490)	purK	83570..84643 (+)	1074	WP_168391516.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
H7790_RS00490	-	84644..85192 (+)	549	WP_228631688.1	hypothetical protein	-
H7790_RS00495	-	85203..85571 (+)	369	WP_228631690.1	hypothetical protein	-
H7790_RS00500 (H7790_00500)	-	85574..86143 (+)	570	WP_032460531.1	hypothetical protein	-
H7790_RS00505 (H7790_00505)	-	86330..86509 (+)	180	WP_032460530.1	hypothetical protein	-
H7790_RS00510 (H7790_00510)	purB	86506..87798 (+)	1293	WP_032460529.1	adenylosuccinate lyase	-
H7790_RS00515 (H7790_00515)	comR	87929..88840 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
H7790_RS09450	comS	88924..89019 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
H7790_RS00520 (H7790_00520)	ruvB	89066..90064 (+)	999	WP_047235090.1	Holliday junction branch migration DNA helicase RuvB	-
H7790_RS00525 (H7790_00525)	-	90202..90639 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
H7790_RS00530 (H7790_00530)	-	90662..91063 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
H7790_RS00535 (H7790_00535)	-	91060..92835 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=477282 H7790_RS00515 WP_002986681.1 87929..88840(+) (comR) [Streptococcus pyogenes strain TSPY1349]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=477282 H7790_RS00515 WP_002986681.1 87929..88840(+) (comR) [Streptococcus pyogenes strain TSPY1349]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462