Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   LCGL_RS12160 Genome accession   NC_017490
Coordinates   445231..445926 (+) Length   231 a.a.
NCBI ID   WP_004259096.1    Uniprot ID   -
Organism   Lactococcus garvieae Lg2     
Function   repress the expression of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 440231..450926
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LCGL_RS12135 (LCGL_0424) - 440464..441165 (+) 702 WP_004259114.1 DeoR/GlpR family DNA-binding transcription regulator -
  LCGL_RS12140 (LCGL_0425) pfkB 441162..442088 (+) 927 WP_004259111.1 1-phosphofructokinase -
  LCGL_RS12145 (LCGL_0426) - 442103..444007 (+) 1905 WP_014024348.1 PTS fructose transporter subunit IIABC -
  LCGL_RS12150 (LCGL_0427) - 444119..444361 (+) 243 WP_003135050.1 type B 50S ribosomal protein L31 -
  LCGL_RS12155 (LCGL_0428) - 444578..445129 (+) 552 WP_014024349.1 YceD family protein -
  LCGL_RS12160 (LCGL_0429) covR 445231..445926 (+) 696 WP_004259096.1 response regulator transcription factor Regulator
  LCGL_RS12165 (LCGL_0430) covS 446015..447505 (+) 1491 WP_014024351.1 HAMP domain-containing histidine kinase Regulator
  LCGL_RS12170 (LCGL_0431) - 447734..448624 (+) 891 WP_014024276.1 IS982-like element ISLgar2 family transposase -
  LCGL_RS12175 (LCGL_0432) - 448918..449235 (+) 318 WP_003131262.1 helix-turn-helix domain-containing protein -
  LCGL_RS12180 (LCGL_0433) - 449269..450036 (+) 768 WP_014570933.1 SGNH/GDSL hydrolase family protein -
  LCGL_RS12185 (LCGL_0434) - 450076..450855 (+) 780 WP_014570934.1 Wzz/FepE/Etk N-terminal domain-containing protein -

Sequence

Protein


Download         Length: 231 a.a.        Molecular weight: 26979.74 Da        Isoelectric Point: 5.4730

>NTDB_id=47620 LCGL_RS12160 WP_004259096.1 445231..445926(+) (covR) [Lactococcus garvieae Lg2]
MNSSKRILIIEDDKNIARFVSLELEHEGYQTAVQGNGRKGLEEAMSKDYDLILLDLMLPELDGFEVARRLRREKDTHIIM
MTARDSTMDRVAGLDIGADDYITKPFAIEELLARVRSLFRREDHIHTIEKSDNTSFRDLVIDKTNRTVHRGKKVIDLTRR
EYDLLLTLMQNVGDVVTREYLVSEVWGYEEGTETNVVDVYIRYLRNKIDVEGRESYIQTVRGMGYVMRDRK

Nucleotide


Download         Length: 696 bp        

>NTDB_id=47620 LCGL_RS12160 WP_004259096.1 445231..445926(+) (covR) [Lactococcus garvieae Lg2]
ATGAATTCATCTAAACGTATTTTGATTATCGAAGACGATAAAAACATTGCGAGATTTGTTTCACTTGAGCTTGAACACGA
AGGATACCAAACTGCGGTTCAAGGCAATGGTCGTAAAGGTCTTGAAGAAGCAATGTCAAAAGATTATGATTTGATTTTGC
TTGACTTAATGCTCCCAGAGCTTGATGGCTTTGAGGTTGCACGACGCTTACGCCGTGAGAAAGATACACATATTATTATG
ATGACTGCACGTGATTCGACAATGGACCGTGTAGCAGGGCTTGATATTGGCGCAGATGACTATATTACAAAACCATTTGC
TATTGAAGAATTGTTAGCGCGTGTCCGCTCACTCTTCCGTCGTGAAGATCATATCCACACGATTGAAAAGTCAGACAATA
CTTCATTCCGTGATTTGGTAATTGATAAGACCAACCGTACTGTACACCGTGGAAAAAAAGTTATTGACCTTACACGCCGT
GAGTACGATTTGCTTTTGACACTGATGCAAAATGTAGGTGATGTCGTAACACGTGAATACTTGGTTTCTGAAGTATGGGG
TTACGAAGAAGGTACAGAAACAAACGTTGTGGACGTTTATATCCGTTATCTGCGTAACAAAATTGACGTGGAGGGCCGTG
AAAGCTATATCCAAACGGTTCGTGGTATGGGATATGTCATGCGTGACCGCAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-227)

Response regulator receiver domain (Response_reg)

(7-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Lactococcus lactis subsp. lactis strain DGCC12653

87.773

99.134

0.87
  covR Streptococcus salivarius strain HSISS4

66.81

100

0.671
  vicR Streptococcus mutans UA159

43.723

100

0.437
  micA Streptococcus pneumoniae Cp1015

42.424

100

0.424

Multiple sequence alignment