Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   H6X75_RS02580 Genome accession   NZ_CP060156
Coordinates   497731..498423 (+) Length   230 a.a.
NCBI ID   WP_223716556.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900700608     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 492731..503423
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H6X75_RS02545 (H6X75_02520) - 493662..493856 (-) 195 WP_001808905.1 hypothetical protein -
  H6X75_RS02550 (H6X75_02525) - 494018..494305 (-) 288 WP_000777753.1 hypothetical protein -
  H6X75_RS02555 (H6X75_02530) - 494315..494725 (-) 411 WP_001278301.1 HIT family protein -
  H6X75_RS02560 (H6X75_02535) pptA 494793..495524 (+) 732 WP_000889921.1 ABC transporter ATP-binding protein Regulator
  H6X75_RS02565 (H6X75_02540) - 495521..496570 (+) 1050 WP_000653771.1 ABC transporter permease -
  H6X75_RS02570 (H6X75_02545) - 496738..497067 (-) 330 WP_000132572.1 hypothetical protein -
  H6X75_RS02575 (H6X75_02550) - 497343..497681 (+) 339 WP_000876675.1 LytTR family DNA-binding domain-containing protein -
  H6X75_RS02580 (H6X75_02555) comE/blpR 497731..498423 (+) 693 WP_223716556.1 LytTR family DNA-binding domain-containing protein Regulator
  H6X75_RS02585 (H6X75_02560) - 498437..499777 (+) 1341 WP_001017642.1 sensor histidine kinase -
  H6X75_RS02590 (H6X75_02565) blpC 499848..499976 (-) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  H6X75_RS02595 (H6X75_02570) - 500033..501394 (-) 1362 WP_001069060.1 bacteriocin secretion accessory protein -
  H6X75_RS02600 (H6X75_02575) comA/nlmT 501405..503081 (-) 1677 WP_196300924.1 peptide cleavage/export ABC transporter Regulator

Sequence

Protein


Download         Length: 230 a.a.        Molecular weight: 26905.90 Da        Isoelectric Point: 6.7684

>NTDB_id=474138 H6X75_RS02580 WP_223716556.1 497731..498423(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700608]
METTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRDPYALIVFVTTHSEFM
PLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYYLETSPRAHRVILYTK
TDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEAINKLH

Nucleotide


Download         Length: 693 bp        

>NTDB_id=474138 H6X75_RS02580 WP_223716556.1 497731..498423(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700608]
ATTGAAACGACGATTGAGAAACTTTTGAAAGCACATCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCA
ACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATCAGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGG
GACTGGAAGTGGCTAGAAAGATTCGGGATCGGGATCCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATG
CCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGACTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGAT
CGAGACAGCCCTCCTCTATGCCAATAGTCAAGATAGTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTG
CCCAATTTCAGTATCCTTTTAAAGAGGTTTACTATCTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAG
ACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGAGGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTT
TCTCATCAATCCTGCAAATGTGGTGCATTTGGATAAGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAA
TCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCCATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(136-226)

Response regulator receiver domain (Response_reg)

(17-107)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.07

99.13

0.526
  comE/comE1 Streptococcus equinus JB1

42.342

96.522

0.409
  comE/comE2 Streptococcus equinus JB1

36.245

99.565

0.361
  comE Streptococcus infantis strain Atu-4

35.622

100

0.361