Detailed information NTG0468192

Bioinformatically predicted

Overview

• Name: comD/blpH
• Type: Regulator
• Locus tag: I6J38_RS10020
• Genome accession: NZ_CP069558
• Coordinates: 158420..159241 (-)
• Length: 273 a.a.
• NCBI ID: WP_235043796.1
• Uniprot ID: -
• Organism: Streptococcus constellatus strain FDAARGOS_1208
• Function: phosphorylation of ComE; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 153420..164241

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6J38_RS00775 (I6J38_00775)	-	153749..154123 (-)	375	WP_022525583.1	hypothetical protein	-
I6J38_RS00780 (I6J38_00780)	comA/nlmT	154607..156757 (+)	2151	WP_006267089.1	peptide cleavage/export ABC transporter	Regulator
I6J38_RS00785 (I6J38_00785)	-	156768..158129 (+)	1362	WP_020999319.1	bacteriocin secretion accessory protein	-
I6J38_RS00790 (I6J38_00790)	-	158226..158375 (+)	150	WP_003037249.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
I6J38_RS10020	comD/blpH	158420..159241 (-)	822	WP_235043796.1	sensor histidine kinase	Regulator
I6J38_RS00800 (I6J38_00800)	comE/blpR	159732..160478 (-)	747	WP_041786327.1	response regulator transcription factor	Regulator
I6J38_RS00805 (I6J38_00805)	-	160647..161360 (-)	714	WP_022525581.1	CPBP family intramembrane glutamic endopeptidase	-
I6J38_RS00810 (I6J38_00810)	-	161592..161813 (+)	222	WP_006267535.1	Blp family class II bacteriocin	-
I6J38_RS00815 (I6J38_00815)	-	162490..162810 (+)	321	WP_006267159.1	hypothetical protein	-
I6J38_RS00820 (I6J38_00820)	-	162818..163051 (+)	234	WP_003025420.1	garvicin Q family class II bacteriocin	-
I6J38_RS00825 (I6J38_00825)	-	163103..163393 (+)	291	WP_006267076.1	bacteriocin immunity protein	-
I6J38_RS00830 (I6J38_00830)	-	163543..163863 (+)	321	WP_006267110.1	hypothetical protein	-

Sequence

Protein

• Length: 273 a.a.
• Molecular weight: 31282.82 Da
• Isoelectric Point: 6.1166

>NTDB_id=468192 I6J38_RS10020 WP_235043796.1 158420..159241(-) (comD/blpH) [Streptococcus constellatus strain FDAARGOS_1208]
MIVYHLIVQVLSYLENESNIQTLNFRESLVVLYLILFVSVANYLDRHLRERIQNDLMLQKDLQLKNMENYSHHIEELYTE
VRSFRHDYANILTTLKLGIEQNDIGIVKNVYHSVLKDSNKRFRNPKYDIGRLVHIKNDALKSLLAAKFAQAQEHNVSVSL
EVPEDICPQGMELIDFITIVSILCDNAIEATTPTMTIAYVLSENKQVFSIENAIKEEHIDMSYIFDAGVSSKGSGRGIGL
SNVLAILDRYPNVSLTSASQNYRFQHVLEIHLN

Nucleotide

• Length: 822 bp

>NTDB_id=468192 I6J38_RS10020 WP_235043796.1 158420..159241(-) (comD/blpH) [Streptococcus constellatus strain FDAARGOS_1208]
ATGATTGTTTATCATCTTATTGTTCAAGTTCTATCTTATTTAGAAAACGAGAGTAACATACAGACACTAAATTTTAGAGA
AAGTTTAGTAGTTCTTTATCTTATCCTTTTTGTGAGTGTTGCCAATTATTTAGACCGTCATTTACGAGAGAGAATCCAAA
ATGATTTAATGCTTCAAAAAGATTTACAGTTAAAAAATATGGAAAACTACAGTCATCACATTGAGGAATTGTACACAGAA
GTTCGGAGCTTTCGGCATGATTACGCTAATATTTTAACAACCTTGAAATTAGGAATTGAGCAAAATGATATAGGCATTGT
AAAGAATGTCTATCATTCTGTTTTGAAAGATTCCAATAAGCGTTTTCGCAATCCCAAGTATGATATTGGACGGTTAGTCC
ATATCAAAAACGATGCCTTAAAAAGCCTGCTAGCTGCTAAATTTGCACAAGCTCAAGAGCATAATGTATCCGTTTCATTG
GAGGTTCCAGAAGATATTTGTCCACAAGGAATGGAATTAATTGACTTTATCACCATTGTCTCCATTTTGTGTGATAATGC
GATTGAAGCTACCACTCCAACTATGACGATTGCTTATGTTTTGTCAGAAAACAAGCAGGTATTCTCCATTGAAAATGCTA
TAAAAGAAGAGCATATAGACATGTCTTATATTTTTGATGCGGGAGTTAGTTCTAAAGGATCTGGGCGAGGAATTGGATTA
TCAAATGTCTTAGCAATTCTGGATCGATATCCAAATGTTTCTCTTACTAGCGCTAGTCAAAATTATCGTTTCCAGCATGT
CCTTGAGATTCATCTGAATTAA

Domains

Predicted by InterProScan.

• GHKL domain (HATPase_c_5) (171-266)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comD/blpH	Streptococcus mutans UA159	43.796	100	0.44
comD/comD3	Streptococcus equinus JB1	41.107	92.674	0.381
comD/comD2	Streptococcus equinus JB1	37.681	100	0.381