Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   JHW37_RS12040 Genome accession   NZ_CP068238
Coordinates   2521130..2521801 (+) Length   223 a.a.
NCBI ID   WP_012075424.1    Uniprot ID   A0A2R3IV09
Organism   Pseudomonas aeruginosa strain A39-1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2516130..2526801
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JHW37_RS12005 (JHW37_12005) ppyR 2516619..2516876 (+) 258 WP_003157851.1 psl/pyoverdine operon transcriptional regulator PpyR -
  JHW37_RS12010 (JHW37_12010) - 2516863..2518056 (+) 1194 WP_033996698.1 NnrS family protein -
  JHW37_RS12015 (JHW37_12015) - 2518057..2518323 (-) 267 WP_034082273.1 DUF5329 domain-containing protein -
  JHW37_RS12020 (JHW37_12020) - 2518307..2519200 (-) 894 WP_012075421.1 hypothetical protein -
  JHW37_RS12025 (JHW37_12025) - 2519227..2520309 (-) 1083 WP_053817058.1 hypothetical protein -
  JHW37_RS12030 (JHW37_12030) - 2520508..2520816 (+) 309 WP_003090497.1 PepSY domain-containing protein -
  JHW37_RS12035 (JHW37_12035) - 2520816..2521130 (+) 315 WP_033996695.1 PepSY domain-containing protein -
  JHW37_RS12040 (JHW37_12040) ciaR 2521130..2521801 (+) 672 WP_012075424.1 two-component system response regulator CarR Regulator
  JHW37_RS12045 (JHW37_12045) carS 2521798..2523132 (+) 1335 WP_012075425.1 two-component system sensor histidine kinase CarS -
  JHW37_RS12050 (JHW37_12050) - 2523236..2523532 (+) 297 WP_176540981.1 hypothetical protein -
  JHW37_RS30250 - 2523537..2524073 (-) 537 Protein_2389 methyl-accepting chemotaxis protein -
  JHW37_RS30255 - 2524443..2525681 (-) 1239 Protein_2390 chemotaxis protein -

Sequence

Protein


Download         Length: 223 a.a.        Molecular weight: 24626.06 Da        Isoelectric Point: 5.8445

>NTDB_id=459228 JHW37_RS12040 WP_012075424.1 2521130..2521801(+) (ciaR) [Pseudomonas aeruginosa strain A39-1]
MRLLLVEDHVPLADELLASLGRQGYAVDWLADGRDAALQGASEPYDLIILDLGLPGRPGLEILREWRGLGLATPVLILTA
RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLSLDEQRQCVCLNGADVDLTAAEFRLLR
YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAGG

Nucleotide


Download         Length: 672 bp        

>NTDB_id=459228 JHW37_RS12040 WP_012075424.1 2521130..2521801(+) (ciaR) [Pseudomonas aeruginosa strain A39-1]
ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCGCTGGCCGACGAACTGCTGGCCAGCCTGGGCCGCCAGGGCTACGCGGT
GGACTGGCTGGCCGACGGCCGCGACGCGGCGCTGCAGGGCGCCAGCGAACCCTACGACCTGATCATCCTCGACCTCGGCC
TGCCTGGCCGCCCCGGCCTGGAGATCCTCCGGGAATGGCGCGGCCTGGGCCTCGCCACCCCGGTGCTGATCCTCACCGCG
CGCGGTTCCTGGGCCGAACGCATCGACGGGCTCAAGGCCGGCGCCGACGACTACCTGACCAAGCCGTTCCATCCGGAAGA
ACTGGCCCTGCGCATCCAGGCCCTGTTGCGCCGCGCCCACGGCCTGGCCAACCAGAGCCAGCTGGAGGCCGCCGGGCTCA
GCCTCGACGAGCAGCGCCAGTGCGTGTGCCTGAACGGTGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC
TATTTCATGCTGCACCCCGGCCAGGTCTTGTCCAAGGGACACCTGGCCGAGCATCTGTACGATGGCGAGACCGAACGCGA
TTCCAACGTCATCGAGGTCCACGTCAACCACCTGCGGCGCAAGCTCGGTCGCGAGGTGATCGAGACCCGCCGTGGGCAGG
GCTACCGCTACGCCGGGGTGGCCGGCGGATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-216)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2R3IV09

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

37.727

98.655

0.372
  ciaR Streptococcus pneumoniae Rx1

37.273

98.655

0.368
  ciaR Streptococcus pneumoniae D39

37.273

98.655

0.368
  ciaR Streptococcus pneumoniae R6

37.273

98.655

0.368
  ciaR Streptococcus pneumoniae TIGR4

37.273

98.655

0.368
  vicR Streptococcus mutans UA159

35.526

100

0.363