Detailed information NTG0453507

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: FOC72_RS07060
• Genome accession: NZ_CP054570
• Coordinates: 1483883..1484545 (+)
• Length: 220 a.a.
• NCBI ID: WP_002896192.1
• Uniprot ID: A0A859ENP7
• Organism: Streptococcus sanguinis strain FDAARGOS_770
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1478883..1489545

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOC72_RS07025 (FOC72_07025)	-	1479101..1479370 (-)	270	WP_002898040.1	DUF3165 family protein	-
FOC72_RS07030 (FOC72_07030)	typA	1479394..1481241 (-)	1848	WP_002932699.1	translational GTPase TypA	-
FOC72_RS07035 (FOC72_07035)	-	1481422..1482147 (+)	726	WP_002896180.1	pseudouridine synthase	-
FOC72_RS07040 (FOC72_07040)	-	1482181..1482420 (-)	240	WP_002896181.1	DUF4190 domain-containing protein	-
FOC72_RS07045 (FOC72_07045)	-	1482510..1482890 (-)	381	WP_002896183.1	rhodanese-like domain-containing protein	-
FOC72_RS07050 (FOC72_07050)	-	1482892..1483110 (-)	219	WP_002896185.1	YqgQ family protein	-
FOC72_RS07055 (FOC72_07055)	-	1483201..1483716 (-)	516	WP_002896187.1	DNA starvation/stationary phase protection protein	-
FOC72_RS07060 (FOC72_07060)	cclA/cilC	1483883..1484545 (+)	663	WP_002896192.1	A24 family peptidase	Machinery gene
FOC72_RS07065 (FOC72_07065)	-	1484539..1485039 (-)	501	WP_002896195.1	effector binding domain-containing protein	-
FOC72_RS07070 (FOC72_07070)	-	1485067..1485966 (+)	900	WP_002896196.1	YafY family protein	-
FOC72_RS11565	-	1486048..1486203 (+)	156	Protein_1396	prepilin peptidase	-
FOC72_RS07075 (FOC72_07075)	trpA	1486172..1486951 (-)	780	WP_002896199.1	tryptophan synthase subunit alpha	-
FOC72_RS07080 (FOC72_07080)	trpB	1486944..1488167 (-)	1224	WP_002896202.1	tryptophan synthase subunit beta	-
FOC72_RS07085 (FOC72_07085)	-	1488157..1488744 (-)	588	WP_002896203.1	phosphoribosylanthranilate isomerase	-
FOC72_RS07090 (FOC72_07090)	trpC	1488731..1489498 (-)	768	WP_002896205.1	indole-3-glycerol phosphate synthase TrpC	-

Sequence

Protein

• Length: 220 a.a.
• Molecular weight: 24805.12 Da
• Isoelectric Point: 8.5733

>NTDB_id=453507 FOC72_RS07060 WP_002896192.1 1483883..1484545(+) (cclA/cilC) [Streptococcus sanguinis strain FDAARGOS_770]
MIHLYFFIVGTVFASFLGLVIDRFPEWSIITPASHCNACGKRLAPRDLIPIFSQILNLLRCRFCGDKIPLRYLFFESILG
SLFLATSLGILSISQLLVVTMGLTLAIYDQREQQYPLMVWLIFQLLLMVTTGVNFLMLFFLALGLLAFFCNLRIGAGDFL
FLASCSAIFSLTEILILIQIASFAGLACFCFKKKKDRLAFVPCLLFGVVVIISYKSLLFY

Nucleotide

• Length: 663 bp

>NTDB_id=453507 FOC72_RS07060 WP_002896192.1 1483883..1484545(+) (cclA/cilC) [Streptococcus sanguinis strain FDAARGOS_770]
ATGATTCACCTATACTTTTTTATCGTTGGTACTGTCTTTGCCTCATTCCTAGGCTTGGTCATCGACCGCTTCCCAGAGTG
GTCTATCATCACTCCCGCTAGCCATTGCAATGCCTGCGGGAAAAGATTGGCACCGCGTGATTTGATCCCTATTTTTTCCC
AAATTTTAAATCTTCTTCGTTGCCGCTTCTGTGGAGACAAGATTCCCTTACGCTATTTATTTTTTGAATCTATCTTGGGC
AGTCTTTTTCTGGCAACCTCCCTGGGCATTCTTTCCATTAGTCAATTATTGGTAGTCACCATGGGCTTAACCTTAGCTAT
CTACGATCAAAGAGAGCAGCAATATCCCCTGATGGTATGGCTGATTTTTCAGCTCTTGCTAATGGTGACAACAGGCGTCA
ACTTTCTCATGCTCTTCTTTTTAGCCCTAGGACTTCTAGCCTTCTTTTGTAATCTTCGTATTGGAGCTGGTGACTTTCTC
TTTCTGGCGTCCTGCTCAGCCATTTTCAGTCTGACGGAAATTCTCATTCTTATCCAAATCGCTAGCTTCGCTGGTCTCGC
CTGTTTTTGCTTTAAAAAGAAAAAAGACAGGCTGGCATTTGTACCCTGTCTTTTGTTTGGTGTGGTGGTGATTATTTCTT
ATAAATCCCTACTCTTTTACTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-86)

3D structure

• AlphaFold DB: A0A859ENP7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus mitis NCTC 12261	59.633	99.091	0.591
cclA/cilC	Streptococcus mitis SK321	59.174	99.091	0.586
cclA/cilC	Streptococcus pneumoniae Rx1	57.339	99.091	0.568
cclA/cilC	Streptococcus pneumoniae D39	57.339	99.091	0.568
cclA/cilC	Streptococcus pneumoniae R6	57.339	99.091	0.568
cclA/cilC	Streptococcus pneumoniae TIGR4	56.881	99.091	0.564