Detailed information NTG0453470

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: I6H78_RS06030
• Genome accession: NZ_CP066059
• Coordinates: 1248365..1250899 (+)
• Length: 844 a.a.
• NCBI ID: WP_198459119.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain FDAARGOS_1021
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1243365..1255899

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H78_RS06005 (I6H78_06005)	nrdI	1243439..1243909 (+)	471	WP_198459116.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
I6H78_RS06010 (I6H78_06010)	-	1243989..1245251 (-)	1263	WP_198459117.1	NRAMP family divalent metal transporter	-
I6H78_RS06015 (I6H78_06015)	-	1245450..1245695 (-)	246	WP_000084865.1	hypothetical protein	-
I6H78_RS06020 (I6H78_06020)	argS	1246022..1247713 (-)	1692	WP_198459118.1	arginine--tRNA ligase	-
I6H78_RS06025 (I6H78_06025)	argR	1247868..1248314 (+)	447	WP_001231483.1	arginine repressor	-
I6H78_RS06030 (I6H78_06030)	hexA	1248365..1250899 (+)	2535	WP_198459119.1	DNA mismatch repair protein MutS	Machinery gene
I6H78_RS06035 (I6H78_06035)	-	1250942..1251400 (-)	459	WP_198459120.1	DUF3021 domain-containing protein	-
I6H78_RS06040 (I6H78_06040)	-	1251397..1251837 (-)	441	WP_198459121.1	LytTR family DNA-binding domain-containing protein	-
I6H78_RS06045 (I6H78_06045)	hexB	1252151..1254100 (+)	1950	WP_198459122.1	DNA mismatch repair endonuclease MutL	Machinery gene
I6H78_RS06050 (I6H78_06050)	-	1254251..1254748 (-)	498	WP_198460233.1	helix-turn-helix domain-containing protein	-
I6H78_RS06055 (I6H78_06055)	ruvA	1254907..1255500 (+)	594	WP_000273410.1	Holliday junction branch migration protein RuvA	Machinery gene

Sequence

Protein

• Length: 844 a.a.
• Molecular weight: 94729.12 Da
• Isoelectric Point: 4.8360

>NTDB_id=453470 I6H78_RS06030 WP_198459119.1 1248365..1250899(+) (hexA) [Streptococcus oralis strain FDAARGOS_1021]
MATEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAINAAQILEISLTSRNKNAENPIPMAGVPYHSAQQYIDVLI
EQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVALDRDGNQFGLAYMDLVTGDFYVTGLLDFTL
VCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKDGFEDVHLLDPRLAAVEQAAASKLLQYVHRTQMRELNHLKP
VIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFF
ERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLGYLIEQLDAIPELECLISAAIAP
EAPHVITEGGIIRTGFDETLDKYRRVLREGTSWIAEIEAKERENSGISTLKIDYNKKDGYYFHVTNSQLGNVPAHFFRKA
TLKNSERFGTEELARIEGDMLEAREKSANLEYEIFMRIREEVSKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFG
DDSQIDIKKGRHAVVEKVMGAQTYIPNSIQMSEDTSIQLITGPNMSGKSTYMRQLAMTAVMAQLGSYVPAESAHLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANNAISHATKDSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHEL
TSLESSLEHLVNVHVATLEQDGQVTFLHKIESGAADKSYGIHVAKIAGLPAELLARADKILTQLENQGTESPAPMRETSA
VTEQMSLFDAPEEHPILAELAKLDVYNMTPMQAMNILVELKQKI

Nucleotide

• Length: 2535 bp

>NTDB_id=453470 I6H78_RS06030 WP_198459119.1 1248365..1250899(+) (hexA) [Streptococcus oralis strain FDAARGOS_1021]
ATGGCAACAGAAAAGCTATCACCCGGCATGCAACAGTATGTGGATATTAAGAAACAATACCCAGATGCTTTTTTGCTTTT
TCGAATGGGTGATTTTTACGAGTTGTTTTATGAAGATGCAATTAATGCAGCACAGATTTTAGAAATTTCCTTAACGAGTC
GGAATAAAAATGCAGAAAATCCGATACCCATGGCGGGTGTCCCCTATCATTCTGCCCAGCAGTATATCGATGTTCTGATT
GAGCAGGGCTATAAGGTAGCCATTGCCGAACAGATGGAAGATCCCAAACAAGCGGTTGGTGTTGTCAAGCGAGAGGTGGT
TCAGGTCATCACACCTGGAACGGTCGTTGATAGCAGTAAGCCGGATAGTCAGAATAATTTCTTGGTTGCTTTAGATCGTG
ATGGCAATCAGTTTGGTCTAGCTTATATGGACCTGGTGACCGGTGATTTTTATGTGACAGGTCTATTAGATTTTACGTTG
GTTTGTGGGGAAATCCGTAACCTAAAGGCTCGTGAAGTGGTGCTGGGTTATGACTTGTCTGAGGAAGAAGAACAAATCCT
CAGCCGTCAGATGAACTTGGTGCTCTCTTATGAGAAGGATGGCTTTGAGGATGTCCATTTACTGGATCCACGTTTGGCAG
CTGTGGAGCAAGCGGCAGCTAGTAAGCTCCTCCAGTATGTTCACCGGACTCAGATGCGGGAATTGAACCACCTCAAACCA
GTTATCCGCTATGAAATTAAAGATTTCTTACAGATGGACTATGCGACCAAGGCTAGTCTGGATTTGGTTGAGAATGCCCG
TTCAGGTAAGAAGCAAGGCAGCCTTTTCTGGCTTTTGGATGAAACCAAAACGGCTATGGGTATGCGGCTCTTACGGTCCT
GGATTCATCGTCCCTTGATTGATAAGGAGCGAATCGTCCAACGTCAAGAGGTGGTGCAGGTCTTTCTTGACCACTTCTTT
GAGCGCAGCGATTTGACAGACAGTCTCAAGGGTGTTTATGATATCGAGCGCTTGGCTAGCCGAGTTTCTTTTGGCAAAAC
CAATCCCAAGGATCTCTTGCAGTTGGCGACCACCTTATCCAGTGTACCACGGATTCGTGCGATTTTAGAAGGCATGGAGC
AGCCTACTCTGGGCTATCTTATCGAACAGTTAGATGCCATCCCTGAGTTGGAGTGCTTGATTAGTGCTGCCATTGCTCCT
GAAGCTCCTCATGTGATTACGGAAGGTGGCATTATCCGTACGGGATTTGATGAGACCTTAGACAAGTACCGTCGTGTGCT
CAGAGAAGGGACTAGTTGGATTGCTGAGATTGAGGCTAAGGAGAGAGAAAACTCTGGCATCAGCACGCTTAAGATTGACT
ACAATAAAAAGGACGGCTACTATTTCCATGTGACCAATTCGCAACTGGGAAATGTGCCAGCCCACTTTTTCCGCAAGGCA
ACGCTGAAAAACTCAGAACGCTTTGGTACCGAAGAATTAGCCCGTATCGAGGGAGATATGCTGGAGGCGCGTGAGAAGTC
AGCCAACCTAGAATACGAAATCTTTATGCGCATCCGTGAGGAAGTCAGCAAGTACATCCAGCGTTTGCAGGCTCTAGCCC
AAGGAATTGCAACGGTTGATGTCTTGCAAAGTCTGGCGGTTGTGGCTGAAACCCAGCATTTGATTCGACCTGAGTTTGGG
GATGATTCACAAATCGATATCAAGAAAGGGCGCCATGCTGTCGTTGAAAAGGTTATGGGAGCTCAGACCTACATTCCAAA
CAGTATTCAGATGTCAGAAGATACCAGCATTCAACTGATTACAGGGCCCAACATGAGTGGGAAGTCTACCTACATGCGTC
AGCTAGCCATGACAGCGGTTATGGCCCAGCTAGGCTCGTATGTACCAGCAGAAAGCGCCCATTTGCCTATCTTCGATGCC
ATCTTTACCCGTATCGGAGCGGCAGATGATTTGGTTTCAGGTCAATCAACCTTCATGGTGGAGATGATGGAGGCCAACAA
TGCCATTTCTCATGCGACCAAGGATTCCTTGATTCTCTTTGATGAATTGGGACGTGGGACTGCAACTTATGACGGAATGG
CTCTGGCCCAATCCATCATCGAATACATCCATGAACATATCGGAGCCAAAACCCTCTTTGCGACCCACTACCATGAGTTG
ACAAGTCTGGAGTCTAGCTTGGAACACTTGGTCAATGTCCACGTGGCAACCTTGGAGCAGGATGGACAGGTTACCTTCCT
TCACAAGATTGAATCAGGAGCAGCTGACAAATCCTATGGTATCCACGTTGCTAAGATTGCTGGTTTACCAGCAGAACTTT
TAGCAAGGGCGGATAAGATATTAACTCAACTGGAGAATCAAGGAACGGAAAGTCCTGCTCCCATGAGAGAAACAAGTGCT
GTCACAGAGCAGATGTCACTCTTTGATGCGCCTGAAGAACATCCTATCCTAGCAGAATTAGCTAAACTGGATGTATACAA
TATGACACCTATGCAGGCTATGAATATCTTAGTTGAGCTTAAACAAAAAATATAA

Domains

Predicted by InterProScan.

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

• MutS domain V (MutS_V) (599-785)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain II (MutS_II) (126-239)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	95.735	100	0.957
mutS	Pseudomonas stutzeri strain ATCC 17587	36.682	100	0.372