NTDB

Overview

Name	dprA	Type	Machinery gene
Locus tag	HPE48_RS17380	Genome accession	NZ_CP054368
Coordinates	3581413..3582537 (+)	Length	374 a.a.
NCBI ID	WP_000228517.1	Uniprot ID	E2QFE2
Organism	Escherichia coli strain SCU-115
Function	ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 3576413..3587537

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HPE48_RS17355 (HPE48_17340)	mscL	3576530..3576943 (-)	414	WP_000022450.1	large-conductance mechanosensitive channel protein MscL	-
HPE48_RS17360 (HPE48_17345)	trkA	3577073..3578449 (-)	1377	WP_000691382.1	Trk system potassium transporter TrkA	-
HPE48_RS17365 (HPE48_17350)	rsmB	3578471..3579760 (-)	1290	WP_021576515.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
HPE48_RS17370 (HPE48_17355)	fmt	3579812..3580759 (-)	948	WP_000004421.1	methionyl-tRNA formyltransferase	-
HPE48_RS17375 (HPE48_17360)	def	3580774..3581283 (-)	510	WP_000114984.1	peptide deformylase	-
HPE48_RS17380 (HPE48_17365)	dprA	3581413..3582537 (+)	1125	WP_000228517.1	DNA-protecting protein DprA	Machinery gene
HPE48_RS17385 (HPE48_17370)	smg	3582509..3582982 (+)	474	WP_000460673.1	DUF494 family protein Smg	-
HPE48_RS17390 (HPE48_17375)	yrdD	3583011..3583553 (+)	543	WP_001312137.1	type I DNA topoisomerase	-
HPE48_RS17395 (HPE48_17380)	tsaC	3583558..3584130 (+)	573	WP_001468260.1	L-threonylcarbamoyladenylate synthase type 1 TsaC	-
HPE48_RS17400 (HPE48_17385)	aroE	3584135..3584953 (+)	819	WP_021540405.1	shikimate dehydrogenase	-
HPE48_RS17405 (HPE48_17390)	yrdB	3584950..3585207 (+)	258	WP_001070563.1	DUF1488 domain-containing protein	-
HPE48_RS17410 (HPE48_17395)	yrdA	3585183..3585737 (-)	555	WP_001286206.1	gamma carbonic anhydrase family protein	-

Sequence

Protein

Download Length: 374 a.a. Molecular weight: 40910.86 Da Isoelectric Point: 6.0395

                                >NTDB_id=452067 HPE48_RS17380 WP_000228517.1 3581413..3582537(+) (dprA) [Escherichia coli strain SCU-115]

MVDTEIWLRLMSISSLYGDDMVRIAHWLAKQSHIDAVVLQQTGLTLRQAQRFLSFPRKSIESSLCWLEQPNHHLIPADSE

FYPPQLLATTDYPGALFVEGELHALHSFQLAVVGSRAHSWYGERWGRLFCETLATRGVTITSGLARGIDGVAHKAALQVN

GVSIAVLGNGLNTIHPRRHAPLAASLLEQGGALVSEFPLDVPPLAYNFPRRNRIISGLSKGVLVVEAALRSGSLVTARCA

LEQGREVFALPGPIGNPGSEGPHWLIKQGAILVTEPEEILENLQFGLHWLPDAPENSFYSPDQEDVALPFPELLANVGDE

VTPVDVVAERAGQPVPEVVTQLLELELAGWIAAVPGGYVRLRRACHVRRTNVFV

Nucleotide

Download Length: 1125 bp

                                >NTDB_id=452067 HPE48_RS17380 WP_000228517.1 3581413..3582537(+) (dprA) [Escherichia coli strain SCU-115]

ATGGTCGATACAGAAATTTGGCTGCGTTTAATGAGCATCAGCAGCTTGTATGGCGATGATATGGTCCGTATAGCTCACTG

GCTGGCAAAACAGTCGCATATTGATGCGGTTGTATTGCAGCAAACAGGGCTTACATTGCGGCAGGCACAACGCTTTCTTT

CATTTCCGCGAAAGAGTATCGAAAGCTCACTTTGTTGGTTGGAGCAACCCAACCATCATTTAATCCCTGCGGACAGCGAA

TTTTATCCTCCTCAACTTCTGGCGACGACAGATTACCCCGGCGCACTGTTTGTTGAAGGAGAACTGCACGCGTTGCATTC

ATTTCAGCTTGCCGTAGTGGGGAGTCGGGCGCATTCATGGTATGGCGAGCGATGGGGACGATTATTTTGCGAAACTCTGG

CGACGCGTGGAGTGACAATTACGAGTGGACTGGCGCGTGGAATCGATGGTGTGGCGCATAAAGCGGCCTTACAGGTAAAT

GGCGTTAGCATTGCTGTATTGGGGAATGGACTTAATACCATTCATCCCCGCCGCCATGCTCCACTGGCTGCCAGTCTACT

TGAGCAAGGTGGTGCTCTCGTCTCGGAATTTCCCCTCGATGTTCCACCCCTTGCTTACAATTTCCCACGAAGAAATCGCA

TTATCAGTGGTCTAAGTAAGGGTGTACTGGTGGTGGAAGCGGCTTTGCGCAGTGGTTCGCTGGTGACAGCACGTTGTGCG

CTTGAGCAGGGGCGTGAAGTTTTTGCTTTGCCAGGTCCAATAGGGAATCCGGGAAGCGAAGGGCCTCACTGGTTAATAAA

ACAAGGTGCGATTCTTGTGACGGAACCGGAAGAAATTCTGGAAAACTTGCAATTTGGATTGCACTGGTTGCCAGACGCCC

CTGAAAATTCATTTTATTCACCAGATCAGGAAGACGTGGCATTGCCATTTCCTGAGCTCCTGGCTAACGTAGGAGATGAG

GTAACACCTGTTGACGTCGTCGCTGAACGTGCCGGCCAACCTGTGCCAGAGGTAGTTACTCAACTACTCGAACTGGAGTT

AGCAGGATGGATCGCAGCTGTACCCGGCGGCTATGTCCGATTGAGGAGGGCATGCCATGTTCGACGTACTAATGTATTTG

TTTGA

Domains

Predicted by InterproScan.

DprA winged helix domain (DprA_WH)

(312-357)

DNA recombination-mediator protein A (DNA_processg_A)

(67-274)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	E2QFE2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
dprA	Vibrio campbellii strain DS40M4	48.78	98.663	0.481
dprA	Vibrio cholerae strain A1552	49.355	82.888	0.409
dprA	Glaesserella parasuis strain SC1401	44.807	90.107	0.404
dprA	Haemophilus influenzae Rd KW20	44.214	90.107	0.398
dprA	Legionella pneumophila strain ERS1305867	44.242	88.235	0.39

Detailed information NTG0452067