Detailed information NTG0452028

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: JAN99_RS03655
• Genome accession: NZ_CP065927
• Coordinates: 713915..716158 (+)
• Length: 747 a.a.
• NCBI ID: WP_136037659.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm9ST603
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 708915..721158

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JAN99_RS03630 (JAN99_03625)	-	709146..711146 (+)	2001	WP_111693287.1	potassium transporter Kup	-
JAN99_RS03635 (JAN99_03630)	-	711170..711448 (-)	279	WP_003057969.1	GIY-YIG nuclease family protein	-
JAN99_RS03640 (JAN99_03635)	-	711438..712214 (-)	777	WP_010922438.1	tRNA1(Val) (adenine(37)-N6)-methyltransferase	-
JAN99_RS03645 (JAN99_03640)	-	712332..713072 (+)	741	WP_002989170.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
JAN99_RS03650 (JAN99_03645)	-	713272..713934 (+)	663	WP_002983967.1	ComEA family DNA-binding protein	-
JAN99_RS03655 (JAN99_03650)	comEC/celB	713915..716158 (+)	2244	WP_136037659.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
JAN99_RS03660 (JAN99_03655)	holA	716229..717269 (+)	1041	WP_011888795.1	DNA polymerase III subunit delta	-
JAN99_RS03665 (JAN99_03660)	sodA	717366..717971 (+)	606	WP_023612500.1	superoxide dismutase SodA	-
JAN99_RS03670 (JAN99_03665)	-	718138..718365 (+)	228	WP_011054657.1	hypothetical protein	-
JAN99_RS03675 (JAN99_03670)	-	718350..718598 (+)	249	WP_111693284.1	serine hydrolase	-
JAN99_RS09245	-	718595..718732 (+)	138	WP_281726975.1	hypothetical protein	-
JAN99_RS03680 (JAN99_03675)	-	718750..719172 (+)	423	WP_281726946.1	hypothetical protein	-
JAN99_RS03685 (JAN99_03680)	-	719286..720506 (-)	1221	WP_111674951.1	DUF3114 domain-containing protein	-

Sequence

Protein

• Length: 747 a.a.
• Molecular weight: 85485.39 Da
• Isoelectric Point: 9.7095

>NTDB_id=452028 JAN99_RS03655 WP_136037659.1 713915..716158(+) (comEC/celB) [Streptococcus pyogenes strain emm9ST603]
MTFSWTKLVPLSKIQFAFLILVLFYQIHSPSWLTFLLSLSLICLLVKRLSKKEFLGVFAILSFCALFLLYQKQQLIQKLE
IQPVQITSVALVPDSIRINGDQLAVLGRHGKHSYQLFYRLKSQAEAQLFKKEHRWLVMHAKVTLEKAEEVRNFKGFNYQT
FLAYQGIYRIGKVEQIEQLEVISPESICDYLSSLRRRAIVHCQQHFPRPMSHYLTGLLFGYLDKSFGEMTDYYSQLGIIH
LFALSGMQVGFFLTCFRRVLLLLAVPLEWIKWIELPFACFYAALTGYSISVIRSLVQSQLRHLGIKGLDNLACTFLLVFL
WDAHFLMTVGGVLTFSYAFLLTVVTVEELSGAKRQLVQVLTISLGILPFLLFYFSSFNPMSMVLTALLSYLFDLFILPLL
CLVFCLSPLVTVSICNHLFILLEKVIQFLGNTFNSSLVFGSPTSWHLLILVISFAIFYDYRQVRQRVITCGLVIALTLLS
VKYPLTNEVTFIDIGQGDSILVREWTGKNLLIDVGGRPFFSSKEHWRRGHHVANAQKTLIPYLKSRGIHTIDQLLVTHAD
TDHMGDIEVVAKAIRIKEILTSQGSLSHPSFVRRLRRLKCHVRVLAAGDQLPIMGSVLQVLYPWQLGDGKNNDSLVLYGR
LLNRTFLFTGDLEKEGENEIIKRYPQLRVDYLKAGHHGSNTSSSAAFLDHIQPKVAFISAGKNNRYQHPHRETLARLEDR
QITYYRTDTQGAIRLTGRTSWHLETVR

Nucleotide

• Length: 2244 bp

>NTDB_id=452028 JAN99_RS03655 WP_136037659.1 713915..716158(+) (comEC/celB) [Streptococcus pyogenes strain emm9ST603]
ATGACATTTTCTTGGACTAAGCTAGTGCCCCTGTCAAAGATTCAATTTGCTTTTTTAATCTTGGTTCTCTTTTATCAAAT
CCATAGCCCTAGCTGGTTAACGTTTCTCCTTAGCCTTAGTTTGATTTGCTTACTTGTCAAGCGTTTGTCTAAAAAAGAAT
TTCTCGGTGTCTTTGCCATCCTTAGTTTCTGTGCTTTGTTTTTGCTGTATCAGAAACAGCAGTTGATTCAAAAACTGGAA
ATTCAGCCAGTACAAATAACCTCTGTAGCATTAGTTCCTGATAGTATTCGGATTAATGGTGATCAATTAGCTGTTCTTGG
ACGTCACGGGAAACATTCTTATCAGTTATTTTACCGTTTGAAAAGCCAAGCAGAAGCCCAATTGTTCAAGAAAGAGCACC
GTTGGTTAGTGATGCACGCAAAAGTGACATTGGAAAAAGCTGAGGAAGTTCGAAATTTTAAAGGCTTTAATTATCAGACT
TTTTTGGCTTATCAAGGAATTTACAGGATAGGGAAGGTAGAGCAAATAGAACAGCTTGAAGTGATTTCACCCGAGTCAAT
ATGTGACTATTTGTCCTCTTTAAGACGACGAGCCATTGTTCATTGCCAGCAGCATTTTCCAAGACCTATGTCTCACTACC
TGACGGGCCTCCTTTTTGGTTATTTAGATAAGTCGTTTGGTGAGATGACAGATTATTATAGTCAGTTGGGTATCATTCAT
CTCTTTGCTTTATCAGGGATGCAGGTTGGCTTCTTTCTTACTTGTTTTAGAAGGGTGTTGCTATTACTCGCAGTTCCTTT
GGAATGGATAAAATGGATAGAACTTCCTTTTGCTTGCTTTTATGCCGCGTTGACAGGTTATAGTATTTCTGTTATTCGAA
GCCTCGTGCAGTCGCAGTTGCGTCATTTAGGAATAAAAGGATTAGACAATCTGGCTTGTACTTTTTTACTTGTCTTTTTA
TGGGATGCTCATTTCTTAATGACTGTTGGTGGCGTATTAACGTTTAGCTATGCTTTTTTGTTAACAGTGGTTACTGTTGA
AGAATTATCAGGAGCTAAAAGACAGTTGGTACAAGTCTTGACCATTTCCCTAGGAATATTACCATTTTTGCTCTTTTATT
TTTCTAGTTTTAACCCAATGTCAATGGTCTTAACAGCTCTCTTGTCTTATCTCTTTGACCTTTTTATTTTGCCCCTTCTT
TGTCTGGTTTTTTGTCTATCCCCTTTGGTGACTGTCTCAATATGCAACCATCTTTTTATTTTATTAGAAAAAGTCATTCA
ATTTCTCGGAAATACTTTCAATAGTTCCCTTGTTTTTGGAAGCCCGACCAGTTGGCACTTGCTTATCTTGGTGATTAGCT
TCGCTATTTTTTATGATTATCGGCAGGTGCGACAACGAGTTATCACTTGCGGTTTGGTTATAGCGTTGACGCTTTTGTCT
GTCAAATATCCTTTGACCAATGAAGTGACCTTTATCGACATTGGCCAGGGAGATAGTATTTTGGTGAGGGAGTGGACAGG
GAAAAATCTCTTAATAGATGTAGGTGGGCGCCCTTTCTTTTCTTCAAAAGAGCACTGGCGACGAGGACATCACGTAGCTA
ATGCTCAGAAAACCTTAATTCCTTACTTAAAAAGTAGAGGTATTCACACAATTGACCAACTATTAGTAACTCACGCAGAT
ACTGATCATATGGGGGATATCGAAGTGGTTGCCAAAGCTATTCGGATAAAGGAGATTTTGACTAGTCAAGGCAGTTTAAG
CCATCCAAGCTTTGTTAGGCGGCTAAGGCGTTTAAAATGTCACGTTAGGGTTTTAGCAGCTGGAGACCAGTTGCCTATTA
TGGGAAGTGTCTTACAGGTACTCTACCCTTGGCAGTTAGGGGACGGGAAAAATAACGATTCTTTGGTACTTTATGGCAGG
CTCTTAAATCGAACTTTTCTTTTCACAGGTGACTTGGAAAAAGAGGGGGAAAACGAGATCATAAAACGTTATCCTCAACT
AAGAGTAGATTATTTAAAAGCAGGTCACCATGGATCAAATACCTCTTCTAGTGCAGCTTTTTTAGACCATATTCAACCTA
AAGTGGCCTTTATTTCTGCTGGAAAAAATAACCGTTATCAGCATCCTCACAGAGAAACCTTAGCCCGTTTGGAAGACAGA
CAAATCACTTATTACCGAACGGATACGCAAGGAGCTATTCGTTTGACTGGTCGGACAAGCTGGCATCTTGAAACGGTCCG
TTAG

Domains

Predicted by InterProScan.

• Competence protein (Competence) (217-462)

• Metallo-beta-lactamase superfamily (Lactamase_B) (495-701)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	46.185	100	0.462
comEC/celB	Streptococcus mitis NCTC 12261	45.979	99.866	0.459
comEC/celB	Streptococcus pneumoniae TIGR4	45.114	100	0.451
comEC/celB	Streptococcus pneumoniae Rx1	44.92	100	0.45
comEC/celB	Streptococcus pneumoniae D39	44.92	100	0.45
comEC/celB	Streptococcus pneumoniae R6	44.92	100	0.45
comEC	Lactococcus lactis subsp. cremoris KW2	40.671	99.732	0.406