Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   HRE60_RS04350 Genome accession   NZ_CP054153
Coordinates   891921..893264 (+) Length   447 a.a.
NCBI ID   WP_118189480.1    Uniprot ID   A0A412F4P5
Organism   Streptococcus salivarius strain DB-B5     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 886921..898264
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HRE60_RS04320 (HRE60_04320) - 886991..887758 (-) 768 WP_104020925.1 amino acid ABC transporter ATP-binding protein -
  HRE60_RS04325 (HRE60_04325) - 887947..888597 (-) 651 WP_181671215.1 amino acid ABC transporter permease -
  HRE60_RS04330 (HRE60_04330) - 888609..889307 (-) 699 WP_002886251.1 amino acid ABC transporter permease -
  HRE60_RS04335 (HRE60_04335) - 889325..890158 (-) 834 WP_181671216.1 transporter substrate-binding domain-containing protein -
  HRE60_RS04340 (HRE60_04340) - 890168..890935 (-) 768 WP_181671217.1 amino acid ABC transporter ATP-binding protein -
  HRE60_RS04345 (HRE60_04345) vicR 891221..891928 (+) 708 WP_002884978.1 response regulator YycF Regulator
  HRE60_RS04350 (HRE60_04350) vicK 891921..893264 (+) 1344 WP_118189480.1 cell wall metabolism sensor histidine kinase VicK Regulator
  HRE60_RS04355 (HRE60_04355) vicX 893267..894079 (+) 813 WP_048675076.1 MBL fold metallo-hydrolase Regulator
  HRE60_RS04360 (HRE60_04360) - 894138..894497 (+) 360 WP_002885010.1 YbaN family protein -
  HRE60_RS04365 (HRE60_04365) - 894549..895763 (-) 1215 WP_181671218.1 aminoacyltransferase -
  HRE60_RS04370 (HRE60_04370) yidA 895765..896574 (-) 810 WP_181671219.1 sugar-phosphatase -
  HRE60_RS04375 (HRE60_04375) - 896752..897618 (+) 867 WP_181671220.1 GNAT family N-acetyltransferase -
  HRE60_RS04380 (HRE60_04380) - 897701..898087 (+) 387 WP_048790817.1 DUF1934 domain-containing protein -

Sequence

Protein


Download         Length: 447 a.a.        Molecular weight: 51075.26 Da        Isoelectric Point: 4.9286

>NTDB_id=451166 HRE60_RS04350 WP_118189480.1 891921..893264(+) (vicK) [Streptococcus salivarius strain DB-B5]
MTSIGLNITSFELALLFTLLFVAFYFIFLAYRDYRRVKNIRKLTKRVKSLMAGNYNEELRLKGDPELLELADSLNDLSDV
FRLTHENLAQEKNRLSSVLSYMSDGVIATNRRGQITMINSTAQRLLNLDYETATQMSILDLLDGENPYTYSELLSKTPEI
HLSRRDANDEFVTLRVNFALIRKESGFISGLVAVLHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDDGALDE
EIAPNFIKVSLDETNRMMRMISDLLALSRIDNKSTQLDVEMTNFTAFMTYILNRFDQIKSQETNTGKTYEIIRDYPVNSI
WVEIDTDKMTQVVDNILNNAIKYSPDGGEITVSMKTTDSQLIVSISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGL
GLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAMMVDEWEME

Nucleotide


Download         Length: 1344 bp        

>NTDB_id=451166 HRE60_RS04350 WP_118189480.1 891921..893264(+) (vicK) [Streptococcus salivarius strain DB-B5]
ATGACTAGTATTGGCTTAAACATCACAAGCTTTGAACTAGCCTTACTCTTTACGCTCCTCTTTGTGGCTTTCTACTTTAT
TTTTCTTGCATATCGTGATTATCGACGAGTCAAAAATATTCGAAAGTTGACCAAGAGGGTCAAGTCCTTAATGGCAGGTA
ACTATAACGAGGAGTTACGCTTAAAGGGTGATCCAGAGCTTTTAGAGCTAGCTGACAGCTTGAATGATTTATCGGATGTC
TTTCGTTTGACGCATGAAAATCTAGCCCAGGAAAAAAACCGCTTATCATCAGTCCTTTCTTACATGAGTGATGGGGTTAT
TGCGACAAATCGTCGTGGTCAAATTACCATGATTAATAGCACAGCTCAGCGTTTGTTGAATCTAGATTATGAAACAGCGA
CACAGATGTCCATTTTAGATTTATTAGATGGCGAAAATCCCTATACTTATAGTGAATTGCTCTCTAAGACTCCTGAAATT
CATTTGTCACGTCGAGATGCTAACGATGAGTTTGTGACCTTACGTGTTAATTTTGCCCTTATTCGTAAAGAATCAGGTTT
TATCTCAGGTCTGGTTGCCGTTCTTCACGATGCCACTGAGCAAGAAAAAGAAGAGCGTGAACGTCGACTCTTCGTCTCAA
ACGTTAGTCATGAGTTGCGTACACCTTTGACTTCTGTAAAATCCTATCTGGAGGCACTTGATGATGGTGCTCTCGACGAA
GAGATTGCTCCTAACTTTATCAAAGTTTCTTTGGATGAGACCAATCGTATGATGCGAATGATTTCTGACCTCTTGGCACT
GTCTCGTATTGACAATAAGAGTACCCAACTTGACGTTGAGATGACCAATTTCACGGCCTTCATGACCTATATATTGAATC
GTTTTGATCAGATTAAAAGTCAAGAAACCAATACAGGTAAAACTTACGAAATCATTCGAGATTACCCAGTAAACTCAATT
TGGGTAGAGATTGATACAGATAAGATGACCCAGGTCGTGGATAATATTCTTAACAATGCCATCAAGTATTCGCCTGATGG
TGGTGAGATTACAGTGTCTATGAAGACAACTGACTCACAGTTGATTGTTTCTATTTCTGACCAAGGTTTGGGTATTCCTA
AGAAAGATTTGCCTTTGATTTTCGACCGTTTTTACCGTGTTGATAAGGCCAGAAGTCGTGCCCAAGGTGGAACTGGTCTA
GGCTTGTCCATTGCAAAAGAAATTATTAAACAACATAAGGGCTTTATTTGGGCTAAGAGTGAGTATGGTAAGGGTTCAAC
TTTTACAATTGTGCTTCCATATGACAAGGATGCCATGATGGTTGATGAATGGGAGATGGAGTAG

Domains

Predicted by InterproScan.

PAS fold (PAS)

(94-197)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(325-435)

His Kinase A (phospho-acceptor) domain (HisKA)

(208-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A412F4P5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

73.43

92.617

0.68
  micB Streptococcus pneumoniae Cp1015

67.436

96.868

0.653