Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   FOC71_RS06360 Genome accession   NZ_CP053999
Coordinates   1261088..1262434 (+) Length   448 a.a.
NCBI ID   WP_003072859.1    Uniprot ID   A0A3R9KNQ5
Organism   Streptococcus intermedius strain FDAARGOS_769     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1256088..1267434
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FOC71_RS06325 (FOC71_06325) - 1256980..1257939 (+) 960 WP_003072868.1 ROK family glucokinase -
  FOC71_RS06330 (FOC71_06330) rplS 1258089..1258436 (+) 348 WP_003072867.1 50S ribosomal protein L19 -
  FOC71_RS06340 (FOC71_06340) - 1258681..1258896 (+) 216 WP_003072866.1 hypothetical protein -
  FOC71_RS09845 - 1259055..1259420 (+) 366 WP_003072864.1 hypothetical protein -
  FOC71_RS06350 (FOC71_06350) - 1259719..1260162 (+) 444 WP_003072862.1 hypothetical protein -
  FOC71_RS06355 (FOC71_06355) ciaR 1260424..1261098 (+) 675 WP_003036714.1 response regulator transcription factor Regulator
  FOC71_RS06360 (FOC71_06360) ciaH 1261088..1262434 (+) 1347 WP_003072859.1 cell wall metabolism sensor histidine kinase WalK Regulator
  FOC71_RS06365 (FOC71_06365) - 1262710..1264158 (-) 1449 WP_003072857.1 alpha-amylase -
  FOC71_RS06370 (FOC71_06370) - 1264528..1265037 (-) 510 WP_003072855.1 DNA topology modulation protein -
  FOC71_RS06375 (FOC71_06375) rpsT 1265102..1265338 (-) 237 WP_003072853.1 30S ribosomal protein S20 -
  FOC71_RS06380 (FOC71_06380) coaA 1265407..1266327 (-) 921 WP_003072849.1 type I pantothenate kinase -
  FOC71_RS06385 (FOC71_06385) - 1266420..1267013 (+) 594 WP_003072846.1 class I SAM-dependent methyltransferase -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50910.65 Da        Isoelectric Point: 10.1689

>NTDB_id=450024 FOC71_RS06360 WP_003072859.1 1261088..1262434(+) (ciaH) [Streptococcus intermedius strain FDAARGOS_769]
MLNKLKKAWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARKVGLEQKSENGE
PKSGTADKELTDKPNVSANTEVILFDKNYKSIITSNNFLGFNKLSFNSKQLDRIRQIQVKSNYGREETYRMVLFQVKLPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDIEPNFFNTTFTNYEMVATENGKVFRF
DNRIHRVIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTITVKDNKPKGTVFEVKIAIRTDNKKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=450024 FOC71_RS06360 WP_003072859.1 1261088..1262434(+) (ciaH) [Streptococcus intermedius strain FDAARGOS_769]
ATGCTGAATAAACTAAAAAAAGCATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCTATGACTTTGATTATCATTCAAGTTATGCGCTCAAGCCTTTATACAACAGTAGATAATAATTTAAAAAGCT
TGAGTCAAGATTCGGCTTCTGTGATTAATTTAGCGCTTGCTCGAAAAGTAGGGCTAGAGCAAAAGTCAGAAAATGGAGAG
CCTAAAAGTGGAACAGCTGATAAAGAGCTGACAGATAAACCAAATGTGAGTGCCAATACAGAAGTTATTTTATTTGATAA
GAATTATAAGTCAATTATTACAAGCAATAATTTTTTAGGGTTTAATAAACTTTCCTTTAATAGCAAGCAATTAGATCGTA
TTCGTCAAATTCAAGTAAAAAGCAATTACGGCCGAGAAGAAACCTATCGGATGGTTTTGTTTCAAGTGAAATTGCCTAAT
TTAGAAACCAATGTCAAATACGCAGCAGTTTTTATCAATATTAGCCAATTGGAACAAACTAGTCAAAACCATGAACAGTT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCTAGTGTCTATCTTGCGCGAGTAAGTGTCAAACCGC
TTTTGGAAAGTATTCAAAAACAAAAGAGCTTTGTCGAAAATGCTAGTCATGAATTACGCACACCTTTAGCCGTTTTGCAA
AATCGTTTGGAGACTTTGTTTAGAAAACCAGAAGCTACCATTATGGAATCGAGTGAAAGCATCGCTTCTAGTTTAGATGA
AGTGCGAAACATGAAAATGTTGACAACGAACTTACTTAATTTAGCACGGCGTGATGATGGGATTAAACCAGAGATTGGTG
ATATTGAACCCAATTTCTTTAATACGACCTTTACGAACTATGAAATGGTTGCCACAGAAAATGGAAAAGTTTTTCGATTT
GACAATAGGATTCATCGTGTGATAAAAACGGATAAAACCTTACTGAAGCAATTGATGACTATCTTATTTGATAATGCCCT
GAAATATACAGATGAAGATGGTGTGATTGAATTGACAATCTCTGCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCAGGGATTAGTACAGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCTCGGACTCGACAG
ACAGGTGGTTTTGGTTTAGGGTTGTCACTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACTATTACAGTGAAAGATAA
TAAACCGAAAGGGACTGTTTTTGAAGTAAAGATTGCGATTCGAACGGATAATAAAAAGAAAAAATAG

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3R9KNQ5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

70.312

100

0.703
  ciaH Streptococcus pneumoniae D39

70.312

100

0.703
  ciaH Streptococcus pneumoniae R6

70.312

100

0.703
  ciaH Streptococcus pneumoniae TIGR4

70.312

100

0.703
  ciaH Streptococcus mutans UA159

55.708

97.768

0.545