Detailed information NTG0450015

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: FOC71_RS04965
• Genome accession: NZ_CP053999
• Coordinates: 954661..955407 (-)
• Length: 248 a.a.
• NCBI ID: WP_037584574.1
• Uniprot ID: -
• Organism: Streptococcus intermedius strain FDAARGOS_769
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 949661..960407

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOC71_RS04950 (FOC71_04950)	-	951652..953013 (+)	1362	WP_003073364.1	bacteriocin secretion accessory protein	-
FOC71_RS04955 (FOC71_04955)	-	953110..953262 (+)	153	WP_003073362.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
FOC71_RS04960 (FOC71_04960)	-	953343..954659 (-)	1317	WP_003073361.1	sensor histidine kinase	-
FOC71_RS04965 (FOC71_04965)	comE/blpR	954661..955407 (-)	747	WP_037584574.1	response regulator transcription factor	Regulator
FOC71_RS04970 (FOC71_04970)	-	955576..956289 (-)	714	WP_003073356.1	CPBP family intramembrane glutamic endopeptidase	-
FOC71_RS04975 (FOC71_04975)	-	956521..956745 (+)	225	WP_003073355.1	Blp family class II bacteriocin	-
FOC71_RS04980 (FOC71_04980)	-	956767..957153 (+)	387	WP_003073353.1	hypothetical protein	-
FOC71_RS04985 (FOC71_04985)	-	957161..957382 (+)	222	WP_003073350.1	Blp family class II bacteriocin	-
FOC71_RS04990 (FOC71_04990)	-	957696..957947 (+)	252	WP_003073349.1	hypothetical protein	-
FOC71_RS04995 (FOC71_04995)	-	958157..958382 (+)	226	Protein_956	bacteriocin class II family protein	-
FOC71_RS05000 (FOC71_05000)	-	958611..958904 (+)	294	WP_003073345.1	bacteriocin immunity protein	-
FOC71_RS05005 (FOC71_05005)	-	958998..959225 (+)	228	WP_003073342.1	bacteriocin	-
FOC71_RS05010 (FOC71_05010)	-	959261..959581 (+)	321	WP_003073339.1	hypothetical protein	-
FOC71_RS05015 (FOC71_05015)	-	959811..960041 (+)	231	WP_003073335.1	Blp family class II bacteriocin	-

Sequence

Protein

• Length: 248 a.a.
• Molecular weight: 28739.16 Da
• Isoelectric Point: 7.3918

>NTDB_id=450015 FOC71_RS04965 WP_037584574.1 954661..955407(-) (comE/blpR) [Streptococcus intermedius strain FDAARGOS_769]
MNIFILEDDLTQQYYMETIVEEIIEKHRLQYHHFEVFGKPKQLLEAISEKGGHQIFFLDIEIKTEEKKGLDVAKKIREID
PYAIIVFVTSHSELMPAAFKLQVGALDYLDKSLSKEALKKRIETALLHTENLTGKGLADDSLLFETPHTQIQVPFKDILY
IETSSRPHRLVLYTHRGRTEFTANLSDMLKKEKRFYQCHRSFVVNPANVHQVDKVNHILHFQNGATCLVSRSKIKGLTEA
IAALHWRE

Nucleotide

• Length: 747 bp

>NTDB_id=450015 FOC71_RS04965 WP_037584574.1 954661..955407(-) (comE/blpR) [Streptococcus intermedius strain FDAARGOS_769]
ATGAATATTTTTATTTTAGAAGATGATCTTACTCAACAATATTATATGGAGACTATTGTTGAAGAAATTATCGAAAAACA
CCGTCTTCAATATCACCATTTTGAAGTTTTTGGAAAACCTAAACAATTACTAGAAGCCATATCTGAGAAAGGAGGCCATC
AGATTTTCTTTTTAGACATTGAAATCAAAACTGAAGAAAAAAAGGGCTTAGACGTCGCCAAAAAGATACGCGAGATAGAT
CCTTATGCCATTATTGTCTTTGTAACCAGTCACTCTGAATTGATGCCGGCAGCGTTTAAACTGCAAGTCGGCGCCCTTGA
CTATCTTGACAAATCGTTATCAAAAGAAGCTTTGAAAAAACGGATCGAAACTGCGCTGCTACATACTGAAAACCTAACAG
GCAAAGGCCTGGCAGACGATTCTCTTCTCTTTGAAACACCTCATACACAAATACAAGTGCCGTTTAAAGATATTCTTTAC
ATTGAAACTTCCTCTCGTCCTCACCGTTTAGTACTTTACACACATAGAGGGCGTACGGAATTTACTGCCAATCTTTCAGA
TATGTTAAAAAAAGAAAAACGGTTCTACCAATGTCATCGTTCCTTTGTTGTTAACCCAGCTAATGTTCATCAAGTGGATA
AAGTAAATCATATCCTTCACTTCCAGAATGGTGCTACTTGTCTTGTTTCTAGATCAAAAATAAAAGGGTTAACAGAAGCT
ATTGCAGCCCTGCACTGGAGGGAATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	50.617	97.984	0.496
comE/comE1	Streptococcus equinus JB1	45.57	95.565	0.435