Detailed information NTG0448964

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: ST4145_RS07575
• Genome accession: NZ_CP065492
• Coordinates: 1473675..1474460 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain 4145
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1468675..1479460

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4145_RS07540 (ST4145_07475)	gatC	1468737..1469039 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
ST4145_RS07545 (ST4145_07480)	-	1469179..1469433 (-)	255	WP_024010053.1	glycosyl transferase	-
ST4145_RS07550 (ST4145_07485)	-	1469446..1469655 (-)	210	WP_080998437.1	glycosyltransferase	-
ST4145_RS07555 (ST4145_07490)	-	1469971..1471415 (-)	1445	Protein_1434	6-phospho-beta-glucosidase	-
ST4145_RS07560 (ST4145_07495)	msrA	1471568..1472077 (-)	510	WP_082245822.1	peptide-methionine (S)-S-oxide reductase MsrA	-
ST4145_RS07565 (ST4145_07500)	-	1472089..1472937 (-)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
ST4145_RS07570 (ST4145_07505)	-	1473061..1473612 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
ST4145_RS07575 (ST4145_07510)	codY	1473675..1474460 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
ST4145_RS07580 (ST4145_07515)	-	1474720..1475934 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
ST4145_RS07585 (ST4145_07520)	-	1476289..1476741 (+)	453	WP_002946987.1	universal stress protein	-
ST4145_RS07590	-	1476921..1477492 (+)	572	Protein_1441	IS30 family transposase	-
ST4145_RS07595 (ST4145_07525)	-	1477564..1477737 (-)	174	WP_011681546.1	hypothetical protein	-
ST4145_RS07600 (ST4145_07530)	-	1477798..1478172 (-)	375	WP_011681547.1	membrane protein	-
ST4145_RS07605 (ST4145_07535)	pflA	1478384..1479184 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=448964 ST4145_RS07575 WP_002951720.1 1473675..1474460(-) (codY) [Streptococcus thermophilus strain 4145]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=448964 ST4145_RS07575 WP_002951720.1 1473675..1474460(-) (codY) [Streptococcus thermophilus strain 4145]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACATTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATCACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502