Detailed information NTG0447405

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: ST4078_RS07740
• Genome accession: NZ_CP065477
• Coordinates: 1485314..1486099 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain 4078
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1480314..1491099

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4078_RS07705 (ST4078_07675)	gatC	1480376..1480678 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
ST4078_RS07710 (ST4078_07680)	-	1480818..1481072 (-)	255	WP_024010053.1	glycosyl transferase	-
ST4078_RS07715 (ST4078_07685)	-	1481085..1481294 (-)	210	WP_080998437.1	glycosyltransferase	-
ST4078_RS07720 (ST4078_07690)	-	1481610..1483054 (-)	1445	Protein_1472	6-phospho-beta-glucosidase	-
ST4078_RS07725 (ST4078_07695)	msrA	1483207..1483716 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
ST4078_RS07730 (ST4078_07700)	-	1483728..1484576 (-)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
ST4078_RS07735 (ST4078_07705)	-	1484700..1485251 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
ST4078_RS07740 (ST4078_07710)	codY	1485314..1486099 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
ST4078_RS07745 (ST4078_07715)	-	1486359..1487573 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
ST4078_RS07750 (ST4078_07720)	-	1487928..1488380 (+)	453	WP_002946987.1	universal stress protein	-
ST4078_RS07755	-	1488560..1489131 (+)	572	Protein_1479	IS30 family transposase	-
ST4078_RS07760 (ST4078_07725)	-	1489203..1489376 (-)	174	WP_011681546.1	hypothetical protein	-
ST4078_RS07765 (ST4078_07730)	-	1489437..1489811 (-)	375	WP_011681547.1	membrane protein	-
ST4078_RS07770 (ST4078_07735)	pflA	1490023..1490823 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=447405 ST4078_RS07740 WP_002951720.1 1485314..1486099(-) (codY) [Streptococcus thermophilus strain 4078]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=447405 ST4078_RS07740 WP_002951720.1 1485314..1486099(-) (codY) [Streptococcus thermophilus strain 4078]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502