Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   MGAS1882_RS04570 Genome accession   NC_017053
Coordinates   928073..928747 (-) Length   224 a.a.
NCBI ID   WP_002984519.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS1882     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 923073..933747
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS1882_RS04545 (MGAS1882_0935) - 923520..923909 (-) 390 WP_011285547.1 cytidine deaminase -
  MGAS1882_RS04550 (MGAS1882_0936) - 924562..925155 (-) 594 WP_014407608.1 class I SAM-dependent methyltransferase -
  MGAS1882_RS04555 (MGAS1882_0937) coaA 925423..926343 (+) 921 WP_014407609.1 type I pantothenate kinase -
  MGAS1882_RS04560 (MGAS1882_0938) rpsT 926397..926645 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  MGAS1882_RS04565 (MGAS1882_0939) ciaH 926770..928080 (-) 1311 WP_011184551.1 sensor histidine kinase Regulator
  MGAS1882_RS04570 (MGAS1882_0940) ciaR 928073..928747 (-) 675 WP_002984519.1 response regulator transcription factor Regulator
  MGAS1882_RS04575 (MGAS1882_0941) - 929094..931631 (-) 2538 WP_014407610.1 M1 family metallopeptidase -
  MGAS1882_RS04580 (MGAS1882_0942) phoU 931836..932489 (-) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  MGAS1882_RS04585 (MGAS1882_0943) pstB 932557..933315 (-) 759 WP_041174337.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25703.91 Da        Isoelectric Point: 4.7287

>NTDB_id=44533 MGAS1882_RS04570 WP_002984519.1 928073..928747(-) (ciaR) [Streptococcus pyogenes MGAS1882]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=44533 MGAS1882_RS04570 WP_002984519.1 928073..928747(-) (ciaR) [Streptococcus pyogenes MGAS1882]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACCAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TTGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGATATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366

Multiple sequence alignment