Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   MGAS15252_RS01495 Genome accession   NC_017040
Coordinates   289064..289750 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS15252     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 284064..294750
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS15252_RS01470 (MGAS15252_0305) ktrB 284207..285583 (-) 1377 WP_041174356.1 potassium uptake transporter channel subunit KtrB -
  MGAS15252_RS01475 (MGAS15252_0306) rsmG 285667..286380 (-) 714 WP_014407313.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  MGAS15252_RS01480 (MGAS15252_0307) - 286530..287087 (+) 558 WP_014407314.1 LemA family protein -
  MGAS15252_RS01485 (MGAS15252_0308) htpX 287134..288030 (+) 897 WP_014407315.1 zinc metalloprotease HtpX -
  MGAS15252_RS01490 (MGAS15252_0309) - 288264..288797 (+) 534 WP_011054200.1 YceD family protein -
  MGAS15252_RS01495 (MGAS15252_0310) covR 289064..289750 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  MGAS15252_RS01500 (MGAS15252_0311) covS 289756..291258 (+) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  MGAS15252_RS01505 (MGAS15252_0312) nrdR 291473..291967 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  MGAS15252_RS01510 (MGAS15252_0313) - 291951..293126 (+) 1176 WP_014407316.1 replication initiation and membrane attachment family protein -
  MGAS15252_RS01515 (MGAS15252_0314) dnaI 293127..294029 (+) 903 WP_014407317.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=44390 MGAS15252_RS01495 WP_002991052.1 289064..289750(+) (covR) [Streptococcus pyogenes MGAS15252]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=44390 MGAS15252_RS01495 WP_002991052.1 289064..289750(+) (covR) [Streptococcus pyogenes MGAS15252]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment