Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGE   Type   Machinery gene
Locus tag   SMUGS5_RS08940 Genome accession   NC_018089
Coordinates   1847143..1847436 (-) Length   97 a.a.
NCBI ID   WP_002263439.1    Uniprot ID   Q8DS53
Organism   Streptococcus mutans GS-5     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1842143..1852436
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUGS5_RS08910 (SMUGS5_08890) - 1842544..1842789 (-) 246 WP_002263444.1 helix-turn-helix transcriptional regulator -
  SMUGS5_RS08915 tnpA 1843414..1843877 (-) 464 Protein_1737 IS200/IS605 family transposase -
  SMUGS5_RS08920 (SMUGS5_08900) - 1844090..1845289 (-) 1200 WP_002263443.1 acetate kinase -
  SMUGS5_RS08925 (SMUGS5_08905) comGH 1845348..1846301 (-) 954 WP_014835049.1 class I SAM-dependent methyltransferase Machinery gene
  SMUGS5_RS10590 comGG 1846356..1846727 (-) 372 WP_042899578.1 competence type IV pilus minor pilin ComGG Machinery gene
  SMUGS5_RS10595 comGF 1846728..1847156 (-) 429 Protein_1741 competence type IV pilus minor pilin ComGF -
  SMUGS5_RS08940 (SMUGS5_08915) comGE 1847143..1847436 (-) 294 WP_002263439.1 competence type IV pilus minor pilin ComGE Machinery gene
  SMUGS5_RS08945 (SMUGS5_08920) comGD 1847408..1847812 (-) 405 WP_002264246.1 competence type IV pilus minor pilin ComGD Machinery gene
  SMUGS5_RS08950 (SMUGS5_08925) comGC 1847799..1848113 (-) 315 WP_002263437.1 competence type IV pilus major pilin ComGC Machinery gene
  SMUGS5_RS08955 (SMUGS5_08930) comGB 1848113..1849144 (-) 1032 WP_255262721.1 competence type IV pilus assembly protein ComGB Machinery gene
  SMUGS5_RS08960 (SMUGS5_08935) comGA 1849080..1850021 (-) 942 WP_002282214.1 competence type IV pilus ATPase ComGA Machinery gene
  SMUGS5_RS08965 (SMUGS5_08940) - 1850151..1850534 (-) 384 WP_002263434.1 DUF1033 family protein -

Sequence

Protein


Download         Length: 97 a.a.        Molecular weight: 11001.91 Da        Isoelectric Point: 9.4908

>NTDB_id=43568 SMUGS5_RS08940 WP_002263439.1 1847143..1847436(-) (comGE) [Streptococcus mutans GS-5]
MVSIKKQKVKAYILLESLVALGLFVTITTLILTQLSHYQERTAKNLQKQEILNLAIMALQTQQDHLSFNGVSVTVVKNQG
ETIVYHDHEEVINLVKK

Nucleotide


Download         Length: 294 bp        

>NTDB_id=43568 SMUGS5_RS08940 WP_002263439.1 1847143..1847436(-) (comGE) [Streptococcus mutans GS-5]
GTGGTCAGTATAAAAAAACAGAAAGTTAAAGCTTATATTCTTCTAGAAAGTTTAGTTGCTTTGGGACTTTTCGTAACCAT
CACAACTTTAATTCTTACTCAGTTGAGTCATTATCAGGAAAGAACAGCTAAAAATTTACAAAAACAAGAAATATTGAATT
TAGCAATAATGGCTCTTCAAACTCAGCAAGATCATTTAAGCTTCAACGGCGTCAGTGTTACGGTTGTTAAAAATCAAGGG
GAAACTATAGTTTATCATGATCATGAGGAGGTTATCAATCTTGTTAAAAAGTAA

Domains

Predicted by InterProScan.

Type II secretory pathway pseudopilin (ComGE)

(13-94)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DS53

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGE Streptococcus mutans UA140

100

100

1
  comGE Streptococcus mutans UA159

100

100

1
  comGE/cglE Streptococcus pneumoniae Rx1

44.444

92.784

0.412
  comGE/cglE Streptococcus pneumoniae D39

44.444

92.784

0.412
  comGE/cglE Streptococcus pneumoniae R6

44.444

92.784

0.412
  comGE/cglE Streptococcus pneumoniae TIGR4

44.444

92.784

0.412
  comGE/cglE Streptococcus mitis NCTC 12261

44.444

92.784

0.412
  comGE/cglE Streptococcus mitis SK321

44.444

92.784

0.412

Multiple sequence alignment