Detailed information NTG0043502

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: SMUGS5_RS02465
• Genome accession: NC_018089
• Coordinates: 496738..497394 (-)
• Length: 218 a.a.
• NCBI ID: WP_002266318.1
• Uniprot ID: Q9KWH4
• Organism: Streptococcus mutans GS-5
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 491738..502394

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMUGS5_RS02440 (SMUGS5_02345)	trpD	492172..493179 (+)	1008	WP_002280744.1	anthranilate phosphoribosyltransferase	-
SMUGS5_RS02445 (SMUGS5_02350)	trpC	493172..493939 (+)	768	WP_002280743.1	indole-3-glycerol phosphate synthase TrpC	-
SMUGS5_RS02450 (SMUGS5_02355)	-	493926..494507 (+)	582	WP_002272562.1	phosphoribosylanthranilate isomerase	-
SMUGS5_RS02455 (SMUGS5_02360)	trpB	494504..495715 (+)	1212	WP_002262056.1	tryptophan synthase subunit beta	-
SMUGS5_RS02460 (SMUGS5_02365)	trpA	495719..496501 (+)	783	WP_002264437.1	tryptophan synthase subunit alpha	-
SMUGS5_RS02465 (SMUGS5_02370)	cclA/cilC	496738..497394 (-)	657	WP_002266318.1	prepilin peptidase	Machinery gene
SMUGS5_RS02470 (SMUGS5_02375)	dpr	497495..498022 (+)	528	WP_002264439.1	DNA starvation/stationary phase protection protein	-
SMUGS5_RS02475 (SMUGS5_02380)	-	498229..498435 (+)	207	WP_014834877.1	YqgQ family protein	-
SMUGS5_RS02480 (SMUGS5_02385)	-	498428..499399 (+)	972	WP_002268147.1	ROK family glucokinase	-
SMUGS5_RS02485 (SMUGS5_02390)	-	499409..499798 (+)	390	WP_002269630.1	rhodanese-like domain-containing protein	-
SMUGS5_RS02490 (SMUGS5_02395)	typA	500031..501875 (+)	1845	WP_002262063.1	translational GTPase TypA	-
SMUGS5_RS02495 (SMUGS5_02400)	-	501904..502158 (+)	255	WP_002262064.1	DUF3165 family protein	-

Sequence

Protein

• Length: 218 a.a.
• Molecular weight: 24893.10 Da
• Isoelectric Point: 8.5763

>NTDB_id=43502 SMUGS5_RS02465 WP_002266318.1 496738..497394(-) (cclA/cilC) [Streptococcus mutans GS-5]
MKLILFFMLGASLGSFFGLVVDRYPQKSIIFPRSHCNKCYNCLTMRDLIPIFSRIINKNSCRFCGYPIPLRYSLVELLCG
LISTGFALDLLTTSQVCLLFMGVLLSLYDLQDQSYPLTLWIGFTFLLMFIYPLNLISLILFLFGIFAALKNINIGSGDFF
YLATLALSLNLQQIIWIIQIASLLGILYSLLFQKHKEPFAFVPFLFLGHLIIIFSHLI

Nucleotide

• Length: 657 bp

>NTDB_id=43502 SMUGS5_RS02465 WP_002266318.1 496738..497394(-) (cclA/cilC) [Streptococcus mutans GS-5]
ATGAAACTTATTTTATTTTTTATGTTAGGAGCTTCTCTTGGCTCTTTCTTTGGCTTAGTTGTTGATCGTTACCCTCAGAA
ATCTATTATATTTCCTAGAAGCCATTGCAATAAGTGTTATAACTGCTTAACCATGAGGGATCTTATCCCAATATTTTCAC
GAATCATCAACAAAAATTCTTGTCGCTTTTGCGGTTACCCTATTCCATTGCGTTATTCCTTGGTAGAATTACTCTGCGGA
CTGATTAGCACAGGTTTTGCTCTTGATTTATTAACCACTTCACAAGTATGTTTGCTCTTCATGGGAGTTCTTTTATCTCT
TTATGATTTACAAGATCAGTCTTATCCTTTGACACTGTGGATAGGCTTTACTTTTCTCTTAATGTTTATCTATCCTCTTA
ACCTAATTAGCTTAATTCTTTTTCTATTTGGTATTTTTGCTGCCCTCAAAAATATTAATATCGGAAGCGGTGATTTCTTC
TATCTGGCTACTTTGGCACTTTCTCTTAATCTTCAGCAAATTATTTGGATTATTCAGATTGCCAGTTTATTAGGAATTCT
TTACAGCCTGCTTTTTCAAAAGCACAAAGAACCTTTTGCTTTTGTTCCTTTCTTATTCTTGGGTCACCTCATTATCATTT
TCTCTCACTTGATTTAA

Domains

Predicted by InterProScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (9-87)

3D structure

• AlphaFold DB: Q9KWH4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus mitis SK321	42.791	98.624	0.422
cclA/cilC	Streptococcus pneumoniae Rx1	42.254	97.706	0.413
cclA/cilC	Streptococcus pneumoniae D39	42.254	97.706	0.413
cclA/cilC	Streptococcus pneumoniae R6	42.254	97.706	0.413
cclA/cilC	Streptococcus mitis NCTC 12261	41.86	98.624	0.413
cclA/cilC	Streptococcus pneumoniae TIGR4	41.315	97.706	0.404