Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   G8B43_RS08350 Genome accession   NZ_CP049689
Coordinates   1630903..1631589 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain ABC221     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1625903..1636589
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  G8B43_RS08330 (G8B43_08390) dnaI 1626624..1627526 (-) 903 WP_011528269.1 primosomal protein DnaI -
  G8B43_RS08335 (G8B43_08395) - 1627527..1628702 (-) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  G8B43_RS08340 (G8B43_08400) nrdR 1628686..1629180 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  G8B43_RS08345 (G8B43_08405) covS 1629395..1630897 (-) 1503 WP_002985946.1 two-component system sensor histidine kinase CovS -
  G8B43_RS08350 (G8B43_08410) covR 1630903..1631589 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  G8B43_RS08355 (G8B43_08415) - 1631856..1632389 (-) 534 WP_011054200.1 DUF177 domain-containing protein -
  G8B43_RS08360 (G8B43_08420) htpX 1632623..1633519 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  G8B43_RS08365 (G8B43_08425) - 1633566..1634123 (-) 558 WP_002985956.1 LemA family protein -
  G8B43_RS08370 (G8B43_08430) rsmG 1634273..1634986 (+) 714 WP_011528267.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  G8B43_RS08375 (G8B43_08435) ktrB 1635070..1636446 (+) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=426828 G8B43_RS08350 WP_002991052.1 1630903..1631589(-) (covR) [Streptococcus pyogenes strain ABC221]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=426828 G8B43_RS08350 WP_002991052.1 1630903..1631589(-) (covR) [Streptococcus pyogenes strain ABC221]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACATATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGACATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425