Detailed information NTG0419819

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: IBL27_RS07255
• Genome accession: NZ_CP061071
• Coordinates: 1483254..1483910 (+)
• Length: 218 a.a.
• NCBI ID: WP_002266318.1
• Uniprot ID: Q9KWH4
• Organism: Streptococcus mutans B04Sm5
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1478254..1488910

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IBL27_RS07225 (IBL27_07225)	-	1478489..1478743 (-)	255	WP_002262064.1	DUF3165 family protein	-
IBL27_RS07230 (IBL27_07230)	typA	1478772..1480616 (-)	1845	WP_002262063.1	translational GTPase TypA	-
IBL27_RS07235 (IBL27_07235)	-	1480850..1481239 (-)	390	WP_002262062.1	rhodanese-like domain-containing protein	-
IBL27_RS07240 (IBL27_07240)	-	1481249..1482220 (-)	972	WP_002268147.1	ROK family glucokinase	-
IBL27_RS07245 (IBL27_07245)	-	1482213..1482419 (-)	207	WP_002262060.1	YqgQ family protein	-
IBL27_RS07250 (IBL27_07250)	dpr	1482626..1483153 (-)	528	WP_002266317.1	DNA starvation/stationary phase protection protein	-
IBL27_RS07255 (IBL27_07255)	cclA/cilC	1483254..1483910 (+)	657	WP_002266318.1	prepilin peptidase	Machinery gene
IBL27_RS07260 (IBL27_07260)	trpA	1484147..1484929 (-)	783	WP_002264437.1	tryptophan synthase subunit alpha	-
IBL27_RS07265 (IBL27_07265)	trpB	1484933..1486144 (-)	1212	WP_002262056.1	tryptophan synthase subunit beta	-
IBL27_RS07270 (IBL27_07270)	-	1486141..1486722 (-)	582	WP_002262055.1	phosphoribosylanthranilate isomerase	-
IBL27_RS07275 (IBL27_07275)	trpC	1486709..1487476 (-)	768	WP_002262054.1	indole-3-glycerol phosphate synthase TrpC	-
IBL27_RS07280 (IBL27_07280)	trpD	1487469..1488476 (-)	1008	WP_002283410.1	anthranilate phosphoribosyltransferase	-

Sequence

Protein

• Length: 218 a.a.
• Molecular weight: 24893.10 Da
• Isoelectric Point: 8.5763

>NTDB_id=419819 IBL27_RS07255 WP_002266318.1 1483254..1483910(+) (cclA/cilC) [Streptococcus mutans B04Sm5]
MKLILFFMLGASLGSFFGLVVDRYPQKSIIFPRSHCNKCYNCLTMRDLIPIFSRIINKNSCRFCGYPIPLRYSLVELLCG
LISTGFALDLLTTSQVCLLFMGVLLSLYDLQDQSYPLTLWIGFTFLLMFIYPLNLISLILFLFGIFAALKNINIGSGDFF
YLATLALSLNLQQIIWIIQIASLLGILYSLLFQKHKEPFAFVPFLFLGHLIIIFSHLI

Nucleotide

• Length: 657 bp

>NTDB_id=419819 IBL27_RS07255 WP_002266318.1 1483254..1483910(+) (cclA/cilC) [Streptococcus mutans B04Sm5]
ATGAAACTTATTTTATTTTTTATGTTGGGAGCTTCTCTTGGCTCTTTCTTTGGCTTAGTTGTTGATCGTTACCCTCAGAA
ATCTATTATATTTCCTAGAAGCCATTGCAATAAGTGTTATAACTGCTTAACCATGAGGGATCTTATCCCAATATTTTCAC
GAATCATCAACAAAAATTCTTGTCGCTTTTGCGGTTACCCTATTCCATTGCGTTATTCCTTGGTAGAATTACTCTGCGGA
CTGATTAGCACAGGTTTTGCTCTTGATTTATTAACCACTTCACAAGTATGTTTGCTCTTCATGGGAGTTCTTTTATCTCT
TTATGATTTACAAGATCAGTCTTATCCTTTGACACTGTGGATAGGCTTTACTTTTCTCTTAATGTTTATCTATCCTCTTA
ACCTAATTAGCTTAATTCTTTTTCTATTTGGTATTTTTGCTGCCCTCAAAAATATTAATATCGGAAGCGGTGATTTCTTC
TATCTGGCTACTTTGGCACTTTCTCTTAATCTTCAGCAAATTATTTGGATTATTCAGATTGCCAGTTTATTAGGAATTCT
TTACAGCCTGCTTTTTCAAAAGCACAAAGAACCTTTTGCTTTTGTTCCTTTCTTATTCTTGGGTCACCTCATTATCATTT
TCTCTCACTTGATTTAA

Domains

Predicted by InterProScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (9-87)

3D structure

• AlphaFold DB: Q9KWH4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus mitis SK321	42.791	98.624	0.422
cclA/cilC	Streptococcus pneumoniae Rx1	42.254	97.706	0.413
cclA/cilC	Streptococcus pneumoniae D39	42.254	97.706	0.413
cclA/cilC	Streptococcus pneumoniae R6	42.254	97.706	0.413
cclA/cilC	Streptococcus mitis NCTC 12261	41.86	98.624	0.413
cclA/cilC	Streptococcus pneumoniae TIGR4	41.315	97.706	0.404