Detailed information NTG0416152

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: H7790_RS02410
• Genome accession: NZ_CP060645
• Coordinates: 453743..454492 (+)
• Length: 249 a.a.
• NCBI ID: WP_136073800.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain TSPY1349
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 448743..459492

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7790_RS09475 (H7790_02400)	-	449086..449397 (+)	312	WP_225793061.1	CPBP family intramembrane glutamic endopeptidase	-
H7790_RS09355	-	449482..449610 (+)	129	WP_002994583.1	hypothetical protein	-
H7790_RS02390 (H7790_02405)	-	450009..450235 (+)	227	Protein_441	ComC/BlpC family peptide pheromone/bacteriocin	-
H7790_RS02395 (H7790_02410)	-	450284..450601 (+)	318	WP_002994587.1	hypothetical protein	-
H7790_RS02400	-	450721..451805 (+)	1085	Protein_443	IS3 family transposase	-
H7790_RS02405 (H7790_02430)	-	452019..453507 (+)	1489	Protein_444	IS1182 family transposase	-
H7790_RS02410 (H7790_02435)	comE/blpR	453743..454492 (+)	750	WP_136073800.1	response regulator transcription factor	Regulator
H7790_RS02415 (H7790_02440)	-	454493..455827 (+)	1335	WP_014635339.1	sensor histidine kinase	-
H7790_RS02420 (H7790_02445)	-	455975..456100 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
H7790_RS02425 (H7790_02450)	-	456177..457541 (-)	1365	WP_115230646.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29113.39 Da
• Isoelectric Point: 5.8302

>NTDB_id=416152 H7790_RS02410 WP_136073800.1 453743..454492(+) (comE/blpR) [Streptococcus pyogenes strain TSPY1349]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNKD
PHAVIVFVTTHSEFMPASFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVSFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=416152 H7790_RS02410 WP_136073800.1 453743..454492(+) (comE/blpR) [Streptococcus pyogenes strain TSPY1349]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAAAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGCATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCTCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTCAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (3-119)

• LytTr DNA-binding domain (LytTR) (150-239)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.098	97.992	0.53
comE/comE2	Streptococcus gordonii strain NCTC7865	40.476	100	0.41
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.476	100	0.41
comE/comE1	Streptococcus equinus JB1	42.437	95.582	0.406
comE/comE2	Streptococcus equinus JB1	40.574	97.992	0.398
comE	Streptococcus mitis NCTC 12261	38.4	100	0.386
comE	Streptococcus mitis SK321	38.4	100	0.386
comE	Streptococcus pneumoniae TIGR4	38	100	0.382
comE	Streptococcus pneumoniae Rx1	38	100	0.382
comE	Streptococcus pneumoniae D39	38	100	0.382
comE	Streptococcus pneumoniae R6	38	100	0.382
comE	Streptococcus infantis strain Atu-4	37.903	99.598	0.378