Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   GQ677_RS00305 Genome accession   NZ_CP047120
Coordinates   37140..38051 (-) Length   303 a.a.
NCBI ID   WP_002986681.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 1085     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 32140..43051
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GQ677_RS00285 (GQ677_00285) - 33145..34920 (-) 1776 WP_010921782.1 acyltransferase family protein -
  GQ677_RS00290 (GQ677_00290) - 34917..35318 (-) 402 WP_010921781.1 MORN repeat-containing protein -
  GQ677_RS00295 (GQ677_00295) - 35341..35778 (-) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  GQ677_RS00300 (GQ677_00300) ruvB 35916..36914 (-) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  GQ677_RS10650 comS 36961..37056 (-) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  GQ677_RS00305 (GQ677_00305) comR 37140..38051 (-) 912 WP_002986681.1 transcriptional regulator Rgg4/ComR Regulator
  GQ677_RS00310 (GQ677_00310) purB 38183..39475 (-) 1293 WP_010921780.1 adenylosuccinate lyase -
  GQ677_RS00315 (GQ677_00315) - 39493..41190 (-) 1698 WP_020904816.1 AIPR family protein -
  GQ677_RS00320 (GQ677_00320) purK 41217..42290 (-) 1074 WP_029714261.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  GQ677_RS00325 (GQ677_00325) purE 42277..42768 (-) 492 WP_002987716.1 5-(carboxyamino)imidazole ribonucleotide mutase -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35757.27 Da        Isoelectric Point: 4.4858

>NTDB_id=410717 GQ677_RS00305 WP_002986681.1 37140..38051(-) (comR) [Streptococcus pyogenes strain 1085]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=410717 GQ677_RS00305 WP_002986681.1 37140..38051(-) (comR) [Streptococcus pyogenes strain 1085]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

100

100

1
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462

Multiple sequence alignment