Detailed information NTG0406191

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: GO995_RS08510
• Genome accession: NZ_CP046624
• Coordinates: 1706003..1706734 (-)
• Length: 243 a.a.
• NCBI ID: WP_157629399.1
• Uniprot ID: -
• Organism: Streptococcus ruminicola strain CNU_G3
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1707460..1716303	1706003..1706734	flank	726

Gene organization within MGE regions

Location: 1706003..1716303

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GO995_RS08510 (GO995_08510)	comE/comE1	1706003..1706734 (-)	732	WP_157629399.1	response regulator transcription factor	Regulator
GO995_RS08515 (GO995_08515)	-	1707765..1708838 (-)	1074	WP_238385871.1	glycosyltransferase family 2 protein	-
GO995_RS08520 (GO995_08520)	-	1709060..1709359 (-)	300	WP_157327346.1	DUF3884 family protein	-
GO995_RS08525 (GO995_08525)	-	1709385..1709567 (-)	183	WP_157327348.1	hypothetical protein	-
GO995_RS08530 (GO995_08530)	-	1709633..1709857 (-)	225	WP_039697856.1	helix-turn-helix domain-containing protein	-
GO995_RS08535 (GO995_08535)	-	1709847..1710845 (-)	999	WP_157629400.1	thioredoxin family protein	-
GO995_RS08540 (GO995_08540)	-	1711075..1711305 (-)	231	WP_074602958.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
GO995_RS08545 (GO995_08545)	comA/nlmT	1711545..1713692 (+)	2148	WP_157629401.1	peptide cleavage/export ABC transporter	Regulator
GO995_RS08550 (GO995_08550)	-	1713702..1715084 (+)	1383	WP_157629402.1	bacteriocin secretion accessory protein	-
GO995_RS08555 (GO995_08555)	-	1715110..1715289 (-)	180	WP_157629403.1	hypothetical protein	-
GO995_RS08560 (GO995_08560)	-	1715629..1716303 (-)	675	WP_133018006.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 243 a.a.
• Molecular weight: 28224.14 Da
• Isoelectric Point: 6.0479

>NTDB_id=406191 GO995_RS08510 WP_157629399.1 1706003..1706734(-) (comE/comE1) [Streptococcus ruminicola strain CNU_G3]
MLDIFILEDNITQQFRIERQIETIMERNHWEYQRLEAFAASKDIIKKADGQGNYQVFFLDLEIKGDEKQGLDVARSIREK
DPTAIIVFVTTHSEFMLLTYQSLVGAIDFIDKNMNDEAFGGRIELCLKEALKYQTGSFGENSYLFETTKARIRVAYDDIL
YFETSPTVHRVILHTKTGQTEFYGTIAEVAKSDKRLLKCHRSFVINVNNVTEFDKSTRTAYFENGSYCQVSRDKVKKLMA
EMR

Nucleotide

• Length: 732 bp

>NTDB_id=406191 GO995_RS08510 WP_157629399.1 1706003..1706734(-) (comE/comE1) [Streptococcus ruminicola strain CNU_G3]
ATGTTAGATATTTTTATCCTTGAGGATAATATCACGCAACAATTTCGAATCGAACGTCAGATTGAGACGATTATGGAAAG
GAACCACTGGGAGTATCAGCGTTTAGAGGCTTTTGCGGCATCTAAGGATATTATAAAAAAGGCAGATGGACAGGGAAATT
ACCAGGTTTTCTTTCTTGATTTAGAAATCAAAGGGGATGAAAAGCAAGGCTTAGATGTTGCTAGATCTATTCGTGAAAAA
GATCCGACAGCCATTATCGTCTTTGTGACAACCCATTCTGAGTTTATGCTTCTAACTTATCAATCACTAGTTGGTGCGAT
TGATTTTATTGATAAAAATATGAATGATGAAGCCTTTGGAGGGCGCATTGAATTGTGCTTGAAAGAGGCATTGAAATATC
AAACTGGTAGTTTTGGTGAGAATTCTTACCTGTTTGAAACAACAAAAGCAAGAATCCGTGTAGCTTATGATGATATTTTA
TATTTTGAAACATCGCCAACTGTGCACCGTGTGATTTTACACACTAAAACAGGTCAAACAGAGTTTTATGGCACAATTGC
TGAGGTAGCCAAATCAGATAAACGTTTGTTGAAATGTCACCGCTCATTCGTGATTAATGTTAATAATGTCACTGAATTTG
ATAAAAGCACCCGAACAGCTTATTTCGAAAACGGCTCTTACTGCCAAGTCTCAAGAGACAAAGTCAAAAAACTGATGGCA
GAAATGAGGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-118)

• LytTr DNA-binding domain (LytTR) (152-240)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	99.177	100	0.992
comE/blpR	Streptococcus mutans UA159	46.473	99.177	0.461
comE/comE2	Streptococcus equinus JB1	45.041	99.588	0.449