Detailed information NTG0403421

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: GL189_RS08385
• Genome accession: NZ_CP046360
• Coordinates: 1657225..1657884 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565005.1
• Uniprot ID: A0A0B7LMM1
• Organism: Streptococcus pneumoniae strain 574
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1652225..1662884

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL189_RS08360 (GL189_08530)	-	1652530..1652847 (-)	318	WP_024477881.1	PTS sugar transporter subunit IIB	-
GL189_RS08365 (GL189_08535)	-	1652862..1653758 (-)	897	WP_000825668.1	PEP phosphonomutase	-
GL189_RS08370 (GL189_08540)	-	1653761..1655023 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
GL189_RS08375 (GL189_08545)	-	1655303..1656481 (+)	1179	WP_024477882.1	ROK family transcriptional regulator	-
GL189_RS08380 (GL189_08550)	-	1656709..1657155 (-)	447	WP_000155425.1	GNAT family N-acetyltransferase	-
GL189_RS08385 (GL189_08555)	cclA/cilC	1657225..1657884 (+)	660	WP_000565005.1	prepilin peptidase	Machinery gene
GL189_RS08390 (GL189_08560)	-	1657936..1659087 (-)	1152	WP_024477883.1	XRE family transcriptional regulator	-
GL189_RS08395 (GL189_08565)	-	1659102..1659833 (-)	732	WP_000934016.1	hypothetical protein	-
GL189_RS08400 (GL189_08570)	-	1660053..1660163 (+)	111	Protein_1677	prepilin peptidase	-
GL189_RS08405 (GL189_08575)	trpA	1660135..1660911 (-)	777	WP_024477884.1	tryptophan synthase subunit alpha	-
GL189_RS08410 (GL189_08580)	trpB	1660904..1662127 (-)	1224	WP_000331293.1	tryptophan synthase subunit beta	-
GL189_RS08415 (GL189_08585)	-	1662105..1662704 (-)	600	WP_050203176.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24846.03 Da
• Isoelectric Point: 7.8950

>NTDB_id=403421 GL189_RS08385 WP_000565005.1 1657225..1657884(+) (cclA/cilC) [Streptococcus pneumoniae strain 574]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSKVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=403421 GL189_RS08385 WP_000565005.1 1657225..1657884(+) (cclA/cilC) [Streptococcus pneumoniae strain 574]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTAAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7LMM1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	99.543	100	0.995
cclA/cilC	Streptococcus pneumoniae D39	99.543	100	0.995
cclA/cilC	Streptococcus pneumoniae R6	99.543	100	0.995
cclA/cilC	Streptococcus pneumoniae TIGR4	94.521	100	0.945
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	87.215	100	0.872