Detailed information NTG0403394

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: GL189_RS02400
• Genome accession: NZ_CP046360
• Coordinates: 466013..466750 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain 574
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 461013..471750

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL189_RS02365 (GL189_02440)	-	461989..462183 (-)	195	WP_001808905.1	hypothetical protein	-
GL189_RS02370 (GL189_02445)	-	462345..462632 (-)	288	WP_000777753.1	hypothetical protein	-
GL189_RS02375 (GL189_02450)	-	462642..463052 (-)	411	WP_001278301.1	HIT family protein	-
GL189_RS02380 (GL189_02455)	pptA	463120..463851 (+)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
GL189_RS02385 (GL189_02460)	-	463848..464897 (+)	1050	WP_000653771.1	ABC transporter permease	-
GL189_RS02390 (GL189_02465)	-	465065..465394 (-)	330	WP_000132572.1	hypothetical protein	-
GL189_RS02395 (GL189_02470)	-	465670..466008 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
GL189_RS02400 (GL189_02475)	comE/blpR	466013..466750 (+)	738	WP_001219120.1	response regulator transcription factor	Regulator
GL189_RS02405 (GL189_02480)	-	466764..468104 (+)	1341	WP_001017642.1	sensor histidine kinase	-
GL189_RS02410 (GL189_02485)	blpC	468175..468303 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
GL189_RS02415 (GL189_02490)	-	468360..469721 (-)	1362	WP_197097175.1	bacteriocin secretion accessory protein	-
GL189_RS02420 (GL189_02495)	comA/nlmT	469732..471408 (-)	1677	WP_215729172.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=403394 GL189_RS02400 WP_001219120.1 466013..466750(+) (comE/blpR) [Streptococcus pneumoniae strain 574]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=403394 GL189_RS02400 WP_001219120.1 466013..466750(+) (comE/blpR) [Streptococcus pneumoniae strain 574]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363