Detailed information NTG0403345

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: GL188_RS08505
• Genome accession: NZ_CP046359
• Coordinates: 1686928..1687587 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565005.1
• Uniprot ID: A0A0B7LMM1
• Organism: Streptococcus pneumoniae strain 573
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1681928..1692587

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL188_RS08480 (GL188_08640)	-	1682233..1682550 (-)	318	WP_024477881.1	PTS sugar transporter subunit IIB	-
GL188_RS08485 (GL188_08645)	-	1682565..1683461 (-)	897	WP_000825668.1	PEP phosphonomutase	-
GL188_RS08490 (GL188_08650)	-	1683464..1684726 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
GL188_RS08495 (GL188_08655)	-	1685006..1686184 (+)	1179	WP_024477882.1	ROK family transcriptional regulator	-
GL188_RS08500 (GL188_08660)	-	1686412..1686858 (-)	447	WP_000155425.1	GNAT family N-acetyltransferase	-
GL188_RS08505 (GL188_08665)	cclA/cilC	1686928..1687587 (+)	660	WP_000565005.1	prepilin peptidase	Machinery gene
GL188_RS08510 (GL188_08670)	-	1687639..1688790 (-)	1152	WP_024477883.1	XRE family transcriptional regulator	-
GL188_RS08515 (GL188_08675)	-	1688805..1689536 (-)	732	WP_000934016.1	hypothetical protein	-
GL188_RS08520 (GL188_08680)	-	1689756..1689866 (+)	111	Protein_1705	prepilin peptidase	-
GL188_RS08525 (GL188_08685)	trpA	1689838..1690614 (-)	777	WP_024477884.1	tryptophan synthase subunit alpha	-
GL188_RS08530 (GL188_08690)	trpB	1690607..1691830 (-)	1224	WP_000331293.1	tryptophan synthase subunit beta	-
GL188_RS08535 (GL188_08695)	-	1691808..1692407 (-)	600	WP_050203176.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24846.03 Da
• Isoelectric Point: 7.8950

>NTDB_id=403345 GL188_RS08505 WP_000565005.1 1686928..1687587(+) (cclA/cilC) [Streptococcus pneumoniae strain 573]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSKVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=403345 GL188_RS08505 WP_000565005.1 1686928..1687587(+) (cclA/cilC) [Streptococcus pneumoniae strain 573]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTAAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7LMM1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	99.543	100	0.995
cclA/cilC	Streptococcus pneumoniae D39	99.543	100	0.995
cclA/cilC	Streptococcus pneumoniae R6	99.543	100	0.995
cclA/cilC	Streptococcus pneumoniae TIGR4	94.521	100	0.945
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	87.215	100	0.872