Detailed information NTG0403265

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: GL186_RS08555
• Genome accession: NZ_CP046358
• Coordinates: 1690267..1690926 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565005.1
• Uniprot ID: A0A0B7LMM1
• Organism: Streptococcus pneumoniae strain 566
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1685267..1695926

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL186_RS08530 (GL186_08705)	-	1685572..1685889 (-)	318	WP_024477881.1	PTS sugar transporter subunit IIB	-
GL186_RS08535 (GL186_08710)	-	1685904..1686800 (-)	897	WP_000825668.1	PEP phosphonomutase	-
GL186_RS08540 (GL186_08715)	-	1686803..1688065 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
GL186_RS08545 (GL186_08720)	-	1688345..1689523 (+)	1179	WP_024477882.1	ROK family transcriptional regulator	-
GL186_RS08550 (GL186_08725)	-	1689751..1690197 (-)	447	WP_000155425.1	GNAT family N-acetyltransferase	-
GL186_RS08555 (GL186_08730)	cclA/cilC	1690267..1690926 (+)	660	WP_000565005.1	prepilin peptidase	Machinery gene
GL186_RS08560 (GL186_08735)	-	1690978..1692129 (-)	1152	WP_024477883.1	XRE family transcriptional regulator	-
GL186_RS08565 (GL186_08740)	-	1692144..1692875 (-)	732	WP_000934016.1	hypothetical protein	-
GL186_RS08570 (GL186_08745)	-	1693095..1693205 (+)	111	Protein_1714	prepilin peptidase	-
GL186_RS08575 (GL186_08750)	trpA	1693177..1693953 (-)	777	WP_024477884.1	tryptophan synthase subunit alpha	-
GL186_RS08580 (GL186_08755)	trpB	1693946..1695169 (-)	1224	WP_000331293.1	tryptophan synthase subunit beta	-
GL186_RS08585 (GL186_08760)	-	1695147..1695746 (-)	600	WP_050203176.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24846.03 Da
• Isoelectric Point: 7.8950

>NTDB_id=403265 GL186_RS08555 WP_000565005.1 1690267..1690926(+) (cclA/cilC) [Streptococcus pneumoniae strain 566]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSKVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=403265 GL186_RS08555 WP_000565005.1 1690267..1690926(+) (cclA/cilC) [Streptococcus pneumoniae strain 566]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTAAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7LMM1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	99.543	100	0.995
cclA/cilC	Streptococcus pneumoniae D39	99.543	100	0.995
cclA/cilC	Streptococcus pneumoniae R6	99.543	100	0.995
cclA/cilC	Streptococcus pneumoniae TIGR4	94.521	100	0.945
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	87.215	100	0.872