Detailed information NTG0403248

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: GL186_RS04350
• Genome accession: NZ_CP046358
• Coordinates: 856524..858764 (+)
• Length: 746 a.a.
• NCBI ID: WP_024477777.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 566
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 851524..863764

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL186_RS04305 (GL186_04425)	-	851674..852642 (+)	969	WP_000658183.1	PhoH family protein	-
GL186_RS04315 (GL186_04435)	-	852835..853336 (+)	502	Protein_866	GNAT family N-acetyltransferase	-
GL186_RS04320 (GL186_04440)	-	853339..853664 (+)	326	Protein_867	TfoX/Sxy family protein	-
GL186_RS11095	ald	853965..855076 (-)	1112	Protein_868	alanine dehydrogenase	-
GL186_RS04340 (GL186_04460)	-	855253..855822 (+)	570	WP_000443774.1	GNAT family N-acetyltransferase	-
GL186_RS04345 (GL186_04465)	comEA/celA/cilE	855890..856540 (+)	651	WP_024477778.1	ComEA family DNA-binding protein	Machinery gene
GL186_RS04350 (GL186_04470)	comEC/celB	856524..858764 (+)	2241	WP_024477777.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
GL186_RS04355 (GL186_04475)	-	858943..859131 (+)	189	WP_001808514.1	hypothetical protein	-
GL186_RS04360 (GL186_04480)	-	859164..859751 (+)	588	WP_000939895.1	ATP-binding cassette domain-containing protein	-
GL186_RS04365 (GL186_04485)	-	859755..860939 (+)	1185	WP_000655960.1	ABC transporter permease	-
GL186_RS04370 (GL186_04490)	infC	861250..861780 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
GL186_RS04375 (GL186_04495)	rpmI	861813..862013 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
GL186_RS04380 (GL186_04500)	rplT	862065..862424 (+)	360	WP_000124836.1	50S ribosomal protein L20	-
GL186_RS04385 (GL186_04505)	-	862482..862862 (+)	381	WP_000157154.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84387.80 Da
• Isoelectric Point: 9.4491

>NTDB_id=403248 GL186_RS04350 WP_024477777.1 856524..858764(+) (comEC/celB) [Streptococcus pneumoniae strain 566]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLVICGIFGFWFVFQNWQQSQASQN
LADSVEGVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWFLILLLISLALVYDLRKNIKKLTVLCLLITGLFLLTK
HPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
ENVGDLSEVTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=403248 GL186_RS04350 WP_024477777.1 856524..858764(+) (comEC/celB) [Streptococcus pneumoniae strain 566]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAGTGATTTGTGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAGGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGTATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTACTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATTTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
GTCACAGGTGACAAGTAGACCTCTGGTCTTTGGACAACCCAATGCATGGTTTTTAATCCTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGAAAAAACATTAAAAAGCTAACGGTATTGTGCTTATTGATTACAGGGCTCTTTCTCCTGACCAAG
CATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGAATGTTGGAGATTTGTCAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Domain of unknown function (DUF4131) (DUF4131) (31-176)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-693)

• Competence protein (Competence) (216-458)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae TIGR4	97.989	100	0.98
comEC/celB	Streptococcus pneumoniae D39	97.721	100	0.977
comEC/celB	Streptococcus pneumoniae R6	97.721	100	0.977
comEC/celB	Streptococcus pneumoniae Rx1	97.721	100	0.977
comEC/celB	Streptococcus mitis SK321	91.957	100	0.92
comEC/celB	Streptococcus mitis NCTC 12261	91.812	99.866	0.917
comEC	Lactococcus lactis subsp. cremoris KW2	44.13	99.33	0.438