Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   GL185_RS08585 Genome accession   NZ_CP046357
Coordinates   1710782..1711735 (+) Length   317 a.a.
NCBI ID   WP_000345122.1    Uniprot ID   A0A0I7TJC1
Organism   Streptococcus pneumoniae strain 525     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1705782..1716735
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL185_RS08540 (GL185_08690) - 1705848..1706213 (+) 366 WP_000286415.1 DUF1033 family protein -
  GL185_RS08545 (GL185_08695) comGA/cglA/cilD 1706288..1707229 (+) 942 WP_000249555.1 competence type IV pilus ATPase ComGA Machinery gene
  GL185_RS08550 (GL185_08700) comGB/cglB 1707177..1708193 (+) 1017 WP_074017570.1 competence type IV pilus assembly protein ComGB Machinery gene
  GL185_RS08555 (GL185_08705) comGC/cglC 1708195..1708521 (+) 327 WP_000738625.1 competence type IV pilus major pilin ComGC Machinery gene
  GL185_RS08560 (GL185_08710) comGD/cglD 1708514..1708918 (+) 405 WP_000588030.1 competence type IV pilus minor pilin ComGD Machinery gene
  GL185_RS08565 (GL185_08715) comGE/cglE 1708881..1709183 (+) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  GL185_RS08570 (GL185_08720) comGF/cglF 1709146..1709607 (+) 462 WP_000250539.1 competence type IV pilus minor pilin ComGF Machinery gene
  GL185_RS08575 (GL185_08725) comGG/cglG 1709585..1710031 (+) 447 WP_001811371.1 competence type IV pilus minor pilin ComGG Machinery gene
  GL185_RS08580 (GL185_08730) - 1710134..1710721 (+) 588 WP_000679779.1 class I SAM-dependent methyltransferase -
  GL185_RS08585 (GL185_08735) comYH 1710782..1711735 (+) 954 WP_000345122.1 class I SAM-dependent methyltransferase Machinery gene
  GL185_RS08590 (GL185_08740) - 1711786..1712976 (+) 1191 WP_000167765.1 acetate kinase -
  GL185_RS11460 - 1712977..1713108 (+) 132 WP_000768904.1 hypothetical protein -
  GL185_RS08595 (GL185_08745) rnpA 1713125..1713496 (+) 372 WP_000739247.1 ribonuclease P protein component -
  GL185_RS08600 (GL185_08750) - 1713471..1714295 (+) 825 WP_000727904.1 membrane protein insertase YidC -
  GL185_RS08605 (GL185_08755) jag 1714314..1715300 (+) 987 WP_000260025.1 RNA-binding cell elongation regulator Jag/EloR -
  GL185_RS08610 (GL185_08760) - 1715351..1715974 (+) 624 WP_000932659.1 hypothetical protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 35745.94 Da        Isoelectric Point: 4.2706

>NTDB_id=403201 GL185_RS08585 WP_000345122.1 1710782..1711735(+) (comYH) [Streptococcus pneumoniae strain 525]
MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGETELNQVKDNNQALKRLALRKEEWLKTYQFLLMKAGQT
EPLQANHQFTPDAIALLLVFIVEELFKEEEITILEMGSGMGILGATFLTSLDKKVDYLGMEMDDLLIDLAASMADVIGLQ
AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGLKYLKSDGYAIFLAPSNLLTSPQ
SDLLKEWLKEEASLVAMISLPENLFANAKQSKTIFILQKKNEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI

Nucleotide


Download         Length: 954 bp        

>NTDB_id=403201 GL185_RS08585 WP_000345122.1 1710782..1711735(+) (comYH) [Streptococcus pneumoniae strain 525]
ATGGATTTTGAAAAAATTGAACAAGCTTATACCTATTTACTAGAGAATGTCCAAGTTATCCAAAGTGATTTGGCGACCAA
CTTTTATGACGCCTTGGTGGAGCAAAACAGCATCTATCTGGATGGTGAAACTGAGCTAAACCAGGTCAAAGACAACAATC
AGGCCCTTAAGCGTTTAGCACTACGCAAAGAAGAATGGCTCAAGACCTACCAGTTTCTCTTGATGAAGGCTGGGCAAACA
GAACCCTTGCAGGCCAATCACCAGTTTACACCAGATGCCATTGCTTTGCTTTTGGTGTTTATTGTGGAAGAGTTGTTTAA
AGAGGAGGAAATTACTATCCTCGAAATGGGTTCTGGGATGGGAATTCTAGGCGCTACTTTCTTGACCTCGCTTGATAAAA
AGGTGGATTACTTGGGAATGGAAATGGATGATTTGCTGATTGATCTGGCAGCTAGCATGGCAGATGTAATTGGTTTGCAG
GCTGGCTTTGTCCAAGGAGATGCCGTTCGTCCACAAATGCTCAAAGAAAGCGATGTGGTCATCAGTGACTTGCCTGTTGG
CTATTATCCTGATGATGCCGTTGCGTCGCGCCATCAAGTTGCTTCTAGCCAAGAACATACTTACGCCCATCACTTGCTCA
TGGAACAAGGGCTTAAGTACCTCAAGTCAGACGGATACGCTATTTTTCTAGCTCCGAGTAATTTGTTGACCAGTCCTCAA
AGTGATTTGTTAAAAGAATGGCTGAAAGAAGAGGCGAGTCTGGTTGCTATGATTAGTCTGCCTGAAAATCTCTTTGCTAA
TGCCAAACAATCTAAGACTATTTTTATCTTACAGAAGAAAAATGAAATAGCAGTAGAGCCTTTTGTTTATCCACTTGCTA
GCTTGCAAGATGCAAGTGTTTTAATGAAATTTAAAGAAAATTTTCAAAAATGGACTCAAGGTACTGAAATATAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(69-282)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0I7TJC1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA140

53.994

98.738

0.533
  comYH Streptococcus mutans UA159

53.674

98.738

0.53

Multiple sequence alignment