Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   GL184_RS06540 Genome accession   NZ_CP046356
Coordinates   1266774..1269014 (-) Length   746 a.a.
NCBI ID   WP_044727637.1    Uniprot ID   A0A0U0ERK9
Organism   Streptococcus pneumoniae strain 521     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1261774..1274014
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL184_RS06505 (GL184_06570) - 1262677..1263057 (-) 381 WP_000157154.1 VOC family protein -
  GL184_RS06510 (GL184_06575) rplT 1263115..1263474 (-) 360 WP_000124836.1 50S ribosomal protein L20 -
  GL184_RS06515 (GL184_06580) rpmI 1263526..1263726 (-) 201 WP_001125943.1 50S ribosomal protein L35 -
  GL184_RS06520 (GL184_06585) infC 1263759..1264289 (-) 531 WP_000848180.1 translation initiation factor IF-3 -
  GL184_RS06525 (GL184_06590) - 1264600..1265784 (-) 1185 WP_083979551.1 hypothetical protein -
  GL184_RS06530 (GL184_06595) - 1265788..1266375 (-) 588 WP_000933542.1 ATP-binding cassette domain-containing protein -
  GL184_RS06535 (GL184_06600) - 1266407..1266595 (-) 189 WP_001809102.1 hypothetical protein -
  GL184_RS06540 (GL184_06605) comEC/celB 1266774..1269014 (-) 2241 WP_044727637.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  GL184_RS06545 (GL184_06610) comEA/celA/cilE 1268998..1269648 (-) 651 WP_094314335.1 ComEA family DNA-binding protein Machinery gene
  GL184_RS06550 (GL184_06615) - 1269716..1270286 (-) 571 Protein_1255 GNAT family N-acetyltransferase -
  GL184_RS11100 ald 1270463..1271574 (+) 1112 Protein_1256 alanine dehydrogenase -
  GL184_RS06570 (GL184_06635) - 1271875..1272200 (-) 326 Protein_1257 TfoX/Sxy family protein -
  GL184_RS06575 (GL184_06640) - 1272203..1272703 (-) 501 WP_000566982.1 GNAT family N-acetyltransferase -
  GL184_RS06585 (GL184_06650) - 1272896..1273864 (-) 969 WP_000658183.1 PhoH family protein -

Sequence

Protein


Download         Length: 746 a.a.        Molecular weight: 84541.16 Da        Isoelectric Point: 9.7665

>NTDB_id=403126 GL184_RS06540 WP_044727637.1 1266774..1269014(-) (comEC/celB) [Streptococcus pneumoniae strain 521]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLNTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIKKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLSEMTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMIVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide


Download         Length: 2241 bp        

>NTDB_id=403126 GL184_RS06540 WP_044727637.1 1266774..1269014(-) (comEC/celB) [Streptococcus pneumoniae strain 521]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGAACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTAGAGGGCATTATTCGCTTGGT
CTCGCAGGTGGCAAGGAGACCGCTTGTCTTTGGTCAACCCAACGCATGGCTTTTAATCTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCAAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGCATGTTGGAGATTTGTCAGAGATGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGATAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

Competence protein (Competence)

(216-458)

Domain of unknown function (DUF4131) (DUF4131)

(30-177)

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-693)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0U0ERK9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus pneumoniae TIGR4

99.33

100

0.993
  comEC/celB Streptococcus pneumoniae Rx1

97.989

100

0.98
  comEC/celB Streptococcus pneumoniae D39

97.989

100

0.98
  comEC/celB Streptococcus pneumoniae R6

97.989

100

0.98
  comEC/celB Streptococcus mitis SK321

92.359

100

0.924
  comEC/celB Streptococcus mitis NCTC 12261

91.812

99.866

0.917
  comEC Lactococcus lactis subsp. cremoris KW2

44.399

99.33

0.441

Multiple sequence alignment