Detailed information NTG0403125

Bioinformatically predicted

Overview

• Name: coiA
• Type: Machinery gene
• Locus tag: GL184_RS06425
• Genome accession: NZ_CP046356
• Coordinates: 1247120..1248073 (-)
• Length: 317 a.a.
• NCBI ID: WP_000495911.1
• Uniprot ID: Q8DQ27
• Organism: Streptococcus pneumoniae strain 521
• Function: homologous recombination (predicted from homology) Homologous recombination

Genomic Context

Location: 1242120..1253073

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL184_RS06400 (GL184_06465)	-	1242609..1242704 (-)	96	Protein_1225	IS630 family transposase	-
GL184_RS06405 (GL184_06470)	-	1243116..1243457 (+)	342	Protein_1226	transposase	-
GL184_RS06410 (GL184_06475)	prsA	1243576..1244517 (-)	942	WP_000727935.1	peptidylprolyl isomerase PrsA	-
GL184_RS06415 (GL184_06480)	-	1244584..1245297 (-)	714	WP_000230399.1	O-methyltransferase	-
GL184_RS06420 (GL184_06485)	pepF	1245299..1247101 (-)	1803	WP_024477773.1	oligoendopeptidase F	Regulator
GL184_RS06425 (GL184_06490)	coiA	1247120..1248073 (-)	954	WP_000495911.1	competence protein CoiA	Machinery gene
GL184_RS06430 (GL184_06495)	tehB	1248146..1249006 (-)	861	WP_000413762.1	SAM-dependent methyltransferase TehB	-
GL184_RS06435 (GL184_06500)	smpB	1249022..1249489 (-)	468	WP_001051750.1	SsrA-binding protein SmpB	-
GL184_RS06440 (GL184_06505)	rnr	1249452..1251806 (-)	2355	WP_024477774.1	ribonuclease R	-
GL184_RS06445 (GL184_06510)	secG	1251908..1252141 (-)	234	WP_000282517.1	preprotein translocase subunit SecG	-
GL184_RS06450 (GL184_06515)	rpmG	1252181..1252330 (-)	150	WP_001809104.1	50S ribosomal protein L33	-

Sequence

Protein

• Length: 317 a.a.
• Molecular weight: 38143.79 Da
• Isoelectric Point: 9.1135

>NTDB_id=403125 GL184_RS06425 WP_000495911.1 1247120..1248073(-) (coiA) [Streptococcus pneumoniae strain 521]
MFVARDARGELVNVLEDKLEKQAYTCPACGGQLHLRQGPSVRTHFAHKSLKDCDFFFENESPEHLANKESLYHWLKKETK
VQLEYPLSELKQIADVFVNGNLALEVQCSPLPQKVLKERSEGYRSQGYQVLWLLGQKLWLKERLTRLQQGFLYFSQNMGF
YVWELDKGKQVLRLKYLIYQDLRGKLHYQIKEFSYGQGSLLEILRLPYKKQKISHFTVSEDKDICRYIRQQLYYQNLFWM
KEQAEAYQKGENILTYGLKEWYPQIRPIVGKFFQIEQDLTSYYQHFYTYYQKNPQNDWQKLYPPAFYQQYFLKNMVE

Nucleotide

• Length: 954 bp

>NTDB_id=403125 GL184_RS06425 WP_000495911.1 1247120..1248073(-) (coiA) [Streptococcus pneumoniae strain 521]
ATGTTTGTTGCGAGAGATGCTAGGGGAGAATTGGTAAATGTGTTAGAGGATAAACTTGAGAAGCAAGCATACACCTGCCC
AGCTTGTGGAGGCCAGCTCCATTTGCGTCAAGGACCAAGTGTACGGACGCATTTTGCCCATAAATCTTTAAAAGACTGTG
ATTTTTTCTTTGAAAATGAAAGTCCAGAACACCTGGCCAATAAGGAATCCCTCTATCACTGGTTGAAAAAAGAGACAAAG
GTTCAATTAGAGTACCCGCTTTCAGAACTTAAACAGATTGCGGATGTATTTGTAAATGGCAATCTAGCTCTAGAAGTTCA
GTGTAGTCCCTTGCCTCAGAAAGTCCTTAAAGAGCGAAGTGAGGGCTATCGTAGTCAGGGTTACCAAGTACTGTGGTTGC
TGGGTCAAAAACTGTGGCTCAAGGAGCGTTTGACTCGTCTACAGCAAGGTTTTCTTTATTTCAGTCAAAACATGGGCTTT
TATGTTTGGGAATTAGACAAGGGAAAACAAGTTTTAAGACTCAAATACCTGATTTACCAGGATCTCCGCGGTAAACTCCA
TTATCAAATCAAGGAATTTTCCTATGGCCAAGGTAGTTTATTGGAAATATTGCGTCTTCCCTATAAGAAACAAAAAATAT
CTCATTTTACAGTTTCTGAGGACAAGGACATCTGTCGCTATATCCGGCAACAACTTTATTATCAAAATCTCTTTTGGATG
AAAGAACAAGCAGAAGCCTATCAAAAGGGAGAAAATATCCTGACTTATGGACTGAAAGAATGGTATCCACAAATTCGACC
AATAGTGGGCAAATTTTTCCAGATTGAACAAGACTTGACTAGCTATTATCAGCACTTTTATACCTATTACCAAAAAAATC
CTCAAAATGATTGGCAAAAGCTTTATCCACCAGCCTTTTATCAGCAATATTTCTTGAAAAATATGGTAGAATAG

Domains

Predicted by InterproScan.

• Competence protein CoiA-like family (CoiA_nuc) (13-263)

3D structure

• AlphaFold DB: Q8DQ27

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
coiA	Streptococcus pneumoniae Rx1	100	100	1
coiA	Streptococcus pneumoniae D39	100	100	1
coiA	Streptococcus pneumoniae R6	100	100	1
coiA	Streptococcus pneumoniae TIGR4	99.369	100	0.994
coiA	Streptococcus mitis NCTC 12261	89.274	100	0.893
coiA	Lactococcus lactis subsp. cremoris KW2	42.593	100	0.435