Detailed information NTG0402787

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: HUW68_RS13510
• Genome accession: NZ_CP055225
• Coordinates: 2686826..2688931 (+)
• Length: 701 a.a.
• NCBI ID: WP_001058983.1
• Uniprot ID: -
• Organism: Staphylococcus aureus LAC
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 2681826..2693931

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HUW68_RS13485 (HUW68_13490)	-	2681965..2682099 (-)	135	WP_001789912.1	hypothetical protein	-
HUW68_RS13490 (HUW68_13495)	-	2682193..2682450 (-)	258	WP_000402605.1	hypothetical protein	-
HUW68_RS13495 (HUW68_13500)	-	2683029..2684306 (-)	1278	WP_001180323.1	hydroxymethylglutaryl-CoA reductase, degradative	-
HUW68_RS13500 (HUW68_13505)	-	2684560..2685726 (+)	1167	WP_000151982.1	hydroxymethylglutaryl-CoA synthase	-
HUW68_RS13505 (HUW68_13510)	-	2685896..2686417 (-)	522	WP_000455987.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
HUW68_RS13510 (HUW68_13515)	clpE	2686826..2688931 (+)	2106	WP_001058983.1	ATP-dependent Clp protease ATP-binding subunit ClpL	Regulator
HUW68_RS13515 (HUW68_13520)	-	2689000..2689170 (-)	171	WP_000111118.1	FeoB-associated Cys-rich membrane protein	-
HUW68_RS13520 (HUW68_13525)	feoB	2689183..2691177 (-)	1995	WP_000432907.1	ferrous iron transport protein B	-
HUW68_RS13525 (HUW68_13530)	-	2691189..2691416 (-)	228	WP_000932073.1	FeoA family protein	-

Sequence

Protein

• Length: 701 a.a.
• Molecular weight: 77852.26 Da
• Isoelectric Point: 4.6294

>NTDB_id=402787 HUW68_RS13510 WP_001058983.1 2686826..2688931(+) (clpE) [Staphylococcus aureus LAC]
MNNGFFNSDFDSIFRRMMKDMQGSNQVGNKKYYINGKEVSPEELAQLTQQGGNHSAEQSAQAFQQAAQRQQGQQGGNGNY
LEQIGRNLTQEARDGLLDPVIGRDKEIQETAEVLSRRTKNNPILVGEAGVGKTAIVEGLAQAIVEGNVPAAIKDKEIISV
DISSLEAGTQYRGAFEENIQKLIEGVKSSQNAVLFFDEIHQIIGSGATGSDSGSKGLSDILKPALSRGEISIIGATTQDE
YRNNILKDSALTRRFNEVLVNEPSAKDTVEILKGIREKFEEHHQVKLPDDVLKACVDLSIQYIPQRLLPDKAIDVLDITA
AHLSAQSPAVDKVETEKRISELENDKRKAVSAEEYKKADDIQNEIKSLQDKLENSNGEHTAVATVHDISDTIQRLTGIPV
SQMDDNDIERLKNISNRLRSKIIGQDQAVEMVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLAIDLFGNKDA
LIRLDMSEYSDTTAVSKMIGTTAGYVGYDDNSNTLTEKVRRNPYSVILFDEIEKANPQILTLLLQVMDDGNLTDGQGNVI
NFKNTIIICTSNAGFGNGNDAEEKDIMHEMKKFFRPEFLNRFNGIVEFLHLDKDALQDIVNLLLDDVQVTLDKKGITMDV
SQDAKDWLIEEGYDEELGARPLRRIVEQQVRDKITDYYLDHTDVKHVDIDVEDNELVVKGK

Nucleotide

• Length: 2106 bp

>NTDB_id=402787 HUW68_RS13510 WP_001058983.1 2686826..2688931(+) (clpE) [Staphylococcus aureus LAC]
ATGAATAACGGTTTTTTCAATAGCGACTTTGATTCAATTTTTCGAAGAATGATGAAAGATATGCAAGGTTCAAATCAAGT
CGGAAACAAAAAGTACTATATTAATGGTAAAGAAGTTTCACCTGAAGAACTAGCGCAACTCACACAACAAGGTGGCAATC
ACTCTGCTGAACAAAGTGCGCAAGCTTTTCAACAAGCAGCACAAAGACAACAAGGGCAACAAGGTGGCAACGGCAATTAT
TTAGAACAAATTGGTCGTAACCTTACGCAAGAAGCACGTGACGGTTTATTAGATCCAGTCATTGGTCGTGATAAAGAAAT
TCAAGAAACTGCTGAAGTTTTAAGTAGACGAACTAAAAACAATCCTATATTAGTTGGAGAAGCTGGTGTTGGTAAAACTG
CGATTGTTGAAGGTTTAGCACAGGCAATCGTTGAAGGAAATGTACCAGCAGCAATCAAAGACAAAGAAATTATTTCTGTA
GACATTTCATCATTAGAAGCTGGAACGCAATATCGTGGTGCTTTTGAAGAAAATATTCAAAAATTAATCGAAGGTGTTAA
ATCTTCACAAAATGCCGTACTATTCTTTGATGAAATCCATCAAATTATCGGTTCAGGTGCCACAGGAAGTGATTCAGGTA
GCAAAGGGTTATCTGATATTTTGAAACCTGCATTAAGTCGTGGTGAGATTTCTATTATTGGTGCAACAACACAAGATGAA
TATCGAAACAATATTCTTAAAGATTCTGCATTAACGCGCAGATTTAATGAAGTGCTTGTTAATGAACCAAGCGCTAAAGA
TACTGTTGAAATTTTAAAAGGTATTCGCGAAAAATTCGAAGAACACCATCAAGTAAAATTACCAGATGACGTATTAAAAG
CATGTGTTGACTTATCAATTCAATATATTCCACAACGATTATTACCAGATAAAGCAATCGATGTGTTAGATATTACAGCA
GCACATTTATCTGCGCAAAGTCCAGCTGTCGATAAAGTTGAAACTGAAAAACGAATTTCTGAATTAGAAAATGATAAACG
TAAAGCAGTAAGTGCTGAAGAATATAAAAAAGCTGACGACATTCAAAATGAAATCAAATCATTACAAGATAAATTAGAAA
ATAGTAATGGTGAACATACTGCTGTTGCTACAGTTCATGATATTTCAGATACTATTCAACGATTAACTGGTATTCCAGTT
TCTCAAATGGATGATAACGATATTGAACGTTTAAAAAATATTTCTAATCGTTTAAGAAGTAAAATCATAGGTCAAGATCA
AGCTGTAGAAATGGTTTCACGTGCAATTCGCCGTAATCGTGCTGGGTTTGATGACGGCAACCGTCCAATTGGCAGTTTCC
TATTTGTTGGCCCTACTGGTGTTGGTAAAACAGAGCTTGCTAAACAATTAGCAATTGATTTATTTGGTAATAAAGATGCA
CTGATTCGACTTGATATGAGTGAATATAGTGACACAACAGCTGTTTCAAAAATGATTGGTACAACTGCTGGTTATGTTGG
TTATGATGACAATTCAAATACGTTAACTGAAAAAGTACGCCGTAATCCATACTCAGTCATTCTATTTGATGAAATCGAAA
AAGCAAATCCACAAATTTTAACATTGTTATTACAAGTAATGGATGATGGTAATTTGACTGATGGTCAAGGTAATGTCATC
AACTTTAAAAATACAATTATTATTTGTACATCAAATGCTGGCTTTGGCAATGGCAATGACGCTGAAGAAAAAGATATTAT
GCACGAAATGAAAAAATTCTTCCGCCCTGAATTCCTTAACCGCTTCAACGGCATCGTTGAATTCTTACATTTAGATAAAG
ATGCATTGCAAGATATCGTCAACTTATTATTAGACGATGTACAAGTTACATTAGACAAAAAAGGTATTACGATGGACGTT
TCTCAAGATGCGAAAGATTGGTTAATTGAAGAAGGCTATGATGAAGAATTAGGTGCACGTCCATTAAGACGTATTGTTGA
ACAGCAAGTACGTGACAAAATTACAGATTACTATTTAGATCATACAGACGTTAAACATGTGGATATAGATGTTGAGGATA
ACGAATTAGTCGTAAAAGGTAAATAA

Domains

Predicted by InterProScan.

• AAA lid domain (AAA_lid_9) (264-363)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (611-682)

• ATPase family associated with various cellular activities (AAA) (AAA) (123-254)

• AAA domain (Cdc48 subfamily) (AAA_2) (448-603)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	48.678	91.726	0.447
clpE	Streptococcus pneumoniae Rx1	48.136	88.017	0.424
clpE	Streptococcus pneumoniae D39	48.136	88.017	0.424
clpE	Streptococcus pneumoniae R6	48.136	88.017	0.424
clpE	Streptococcus pneumoniae TIGR4	48.136	88.017	0.424
clpC	Lactococcus lactis subsp. cremoris KW2	46.656	89.586	0.418
clpC	Bacillus subtilis subsp. subtilis str. 168	44.41	93.153	0.414
clpC	Streptococcus thermophilus LMD-9	44.234	90.3	0.399
clpC	Streptococcus thermophilus LMG 18311	43.918	90.3	0.397
clpC	Streptococcus pneumoniae TIGR4	44.013	88.16	0.388
clpC	Streptococcus pneumoniae Rx1	44.013	88.16	0.388
clpC	Streptococcus pneumoniae D39	44.013	88.16	0.388
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	41.294	92.582	0.382
clpC	Streptococcus mutans UA159	43.415	87.732	0.381