Detailed information NTG0402665

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: FOB91_RS04005
• Genome accession: NZ_CP046328
• Coordinates: 828537..830777 (-)
• Length: 746 a.a.
• NCBI ID: WP_012130665.1
• Uniprot ID: A8AYL9
• Organism: Streptococcus gordonii strain FDAARGOS_683
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 823537..835777

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOB91_RS03975 (FOB91_03975)	-	823810..824307 (-)	498	WP_012130659.1	DUF1648 domain-containing protein	-
FOB91_RS03980 (FOB91_03980)	-	824294..824575 (-)	282	WP_012130660.1	autorepressor SdpR family transcription factor	-
FOB91_RS03985 (FOB91_03985)	-	824553..825341 (-)	789	WP_012130661.1	YhfC family intramembrane metalloprotease	-
FOB91_RS03990 (FOB91_03990)	-	825546..826619 (-)	1074	WP_012130662.1	serine hydrolase	-
FOB91_RS03995 (FOB91_03995)	-	826731..827336 (-)	606	WP_012130663.1	superoxide dismutase	-
FOB91_RS04000 (FOB91_04000)	holA	827409..828446 (-)	1038	WP_012130664.1	DNA polymerase III subunit delta	-
FOB91_RS04005 (FOB91_04005)	comEC/celB	828537..830777 (-)	2241	WP_012130665.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
FOB91_RS04010 (FOB91_04010)	comEA/celA/cilE	830761..831426 (-)	666	WP_012130666.1	helix-hairpin-helix domain-containing protein	Machinery gene
FOB91_RS04015 (FOB91_04015)	-	831523..832050 (-)	528	WP_012130667.1	HXXEE domain-containing protein	-
FOB91_RS04020 (FOB91_04020)	-	832089..832829 (-)	741	WP_041789898.1	lysophospholipid acyltransferase family protein	-
FOB91_RS04025 (FOB91_04025)	-	832959..835328 (+)	2370	WP_012130669.1	cation-translocating P-type ATPase	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 85524.30 Da
• Isoelectric Point: 9.8278

>NTDB_id=402665 FOB91_RS04005 WP_012130665.1 828537..830777(-) (comEC/celB) [Streptococcus gordonii strain FDAARGOS_683]
MSQWIKKLPLAPIYLCFLLVWLYFAIYSGERLAYLGYSLLIARLIWHYPRKKWLPTLAILIAFSFFFYARRELAERAFQT
QPAPARQVLVLPDTVKVNGDSLSFRGRIDGRLYQLYYKLASPREKKTFQKLTDLVTLEIEAEFNLAEERRNFSGFDYQAY
LKSQGIYRTVKISRIMSSRSSQSTNPFDWLSVWRRKALVFIKSTFPSPMSHYMTGLLFGDLDIDFAEMNGLYSSLGIIHL
FALSGMQVGFFMDVFRKILLRIGLRMETVDWLQFPLSFLYAGLTGFSVSVVRSLVQKLLSQFGVRRLDNFAMTMLVLMLL
MPSFLLTTGGVLSCAYAFIITMLDFEDSSGFRKAVLESLSISLGILPLLIYYFAEFQPWSILLTFLFSIVFDTFMLPLLS
LIFLISPLFAFTQVNVFFQWLEMVIRWVASLSTRPIILGQPNLPLLIILLLVLALLYDFRKQKKIRAGLSLLAILLFFLS
KHPLQNEITVVDIGQGDSIFLRDVRGRTIVIDTGGRVEIGKKEAWQERVRKSNAETTLIPYLKSRGVDHLDQLVLTHTDT
DHMGDMLELAKHFSIREIYVSKGSMTQVDFVDKLKKMKAKVHVVEVGDRLPIFDSALEVLYPLGQGDGGNDDSIVLYGEF
FRTKFLFTGDLEAPGEGQMVTAYPDLRVDVLKAGHHGSKGSSSPEFLEHIKPKLALISAGKNNRYQHPHKETLDRFEKIQ
TKIFRTDEQGAIRFKGWNSWQIETVR

Nucleotide

• Length: 2241 bp

>NTDB_id=402665 FOB91_RS04005 WP_012130665.1 828537..830777(-) (comEC/celB) [Streptococcus gordonii strain FDAARGOS_683]
ATGTCACAGTGGATTAAAAAACTTCCCCTTGCTCCAATCTACTTGTGCTTTCTTTTGGTTTGGCTATACTTTGCTATTTA
TAGTGGTGAAAGACTCGCTTATCTAGGTTATTCCCTTCTTATAGCTCGCCTAATCTGGCATTATCCAAGAAAGAAATGGT
TGCCAACTTTAGCTATTCTAATTGCTTTCTCTTTCTTTTTTTATGCTAGACGTGAGTTGGCGGAACGAGCTTTTCAGACT
CAACCAGCTCCTGCAAGACAAGTTCTTGTTTTACCAGATACTGTTAAAGTGAATGGAGATTCCCTATCTTTCCGTGGTAG
AATAGACGGAAGACTTTATCAGCTCTACTACAAATTAGCAAGTCCAAGAGAGAAAAAAACTTTTCAAAAACTAACTGACT
TGGTCACTTTAGAGATTGAAGCAGAGTTCAATCTAGCAGAAGAACGGCGCAATTTCTCTGGCTTTGACTATCAGGCTTAT
TTAAAAAGTCAGGGAATCTATCGGACTGTTAAGATCAGTAGGATTATGTCTAGTCGTTCTAGTCAGTCTACTAATCCATT
TGATTGGCTGTCTGTTTGGCGTAGGAAGGCCTTGGTTTTCATTAAGTCTACTTTTCCAAGCCCGATGAGTCACTACATGA
CAGGACTCTTGTTTGGTGATTTAGATATTGATTTTGCAGAGATGAATGGCTTGTACTCAAGTTTAGGAATTATCCATCTT
TTTGCTTTATCAGGAATGCAAGTTGGTTTTTTTATGGATGTCTTTCGGAAAATTCTTCTGCGCATAGGCTTAAGGATGGA
AACGGTAGATTGGTTGCAATTCCCGTTGTCCTTTCTTTATGCAGGTTTGACTGGATTTTCTGTGTCAGTAGTGAGGAGTT
TAGTGCAAAAGTTGTTGTCTCAATTTGGAGTGAGGCGCTTGGATAATTTTGCGATGACCATGCTGGTCCTAATGCTTCTT
ATGCCAAGCTTTCTCCTGACAACAGGCGGAGTCCTATCTTGCGCTTATGCCTTTATCATCACTATGTTGGATTTTGAGGA
TTCTAGTGGTTTTCGTAAAGCCGTGCTAGAGAGTTTAAGTATCTCGTTAGGCATTTTACCACTTCTTATCTATTATTTTG
CAGAATTCCAGCCTTGGTCTATCCTCTTGACCTTCCTTTTTTCAATCGTCTTTGATACATTTATGTTACCTCTCTTGAGT
CTAATTTTTCTCATTTCGCCTTTGTTTGCCTTCACTCAAGTTAATGTCTTCTTCCAATGGCTGGAAATGGTGATTCGTTG
GGTAGCTAGTTTGTCAACAAGGCCGATAATTTTAGGACAGCCAAATCTGCCTTTGCTTATTATTCTCCTGCTGGTCTTAG
CCCTGCTCTATGACTTTAGAAAACAAAAAAAGATTAGAGCTGGCCTGAGTCTCTTAGCAATCTTACTATTTTTCCTAAGT
AAACATCCTTTACAAAATGAAATCACAGTGGTAGATATTGGGCAGGGAGACAGTATATTTCTGAGGGATGTCAGAGGTAG
GACTATCGTAATTGATACAGGGGGTCGGGTGGAGATTGGTAAAAAAGAGGCTTGGCAAGAGCGAGTTAGAAAAAGCAATG
CGGAAACGACCTTGATCCCTTATCTAAAAAGCCGAGGAGTGGACCACTTGGATCAATTAGTCCTGACTCACACAGATACA
GACCATATGGGAGATATGTTGGAGTTGGCCAAGCACTTTTCTATCCGAGAAATTTATGTTTCCAAAGGAAGTATGACTCA
AGTTGATTTTGTAGACAAGTTAAAGAAGATGAAAGCTAAAGTTCATGTGGTCGAGGTGGGAGATCGGCTTCCTATCTTTG
ATTCGGCCCTTGAAGTGCTCTATCCACTAGGTCAAGGAGATGGTGGTAATGATGACTCGATTGTCTTGTATGGTGAATTT
TTCCGGACCAAGTTTCTTTTCACAGGAGATTTAGAAGCTCCAGGTGAAGGTCAGATGGTGACAGCCTATCCAGATTTAAG
AGTAGATGTGCTCAAAGCTGGGCATCATGGTTCTAAAGGATCTTCTAGTCCAGAATTTCTAGAGCATATTAAGCCTAAGT
TGGCCTTGATTTCAGCTGGTAAAAACAACCGTTACCAACATCCCCATAAGGAAACTTTAGATAGATTCGAAAAAATCCAG
ACTAAGATTTTTCGGACAGATGAGCAGGGAGCTATTCGATTTAAAGGCTGGAATTCTTGGCAGATAGAAACGGTTCGCTA
G

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (494-700)

• Competence protein (Competence) (216-460)

3D structure

• AlphaFold DB: A8AYL9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	58.233	100	0.583
comEC/celB	Streptococcus mitis NCTC 12261	57.641	100	0.576
comEC/celB	Streptococcus pneumoniae TIGR4	56.894	100	0.57
comEC/celB	Streptococcus pneumoniae Rx1	56.627	100	0.567
comEC/celB	Streptococcus pneumoniae D39	56.627	100	0.567
comEC/celB	Streptococcus pneumoniae R6	56.627	100	0.567
comEC	Lactococcus lactis subsp. cremoris KW2	50.269	99.732	0.501