Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SALIVA_RS00340 Genome accession   NC_017595
Coordinates   58885..60828 (+) Length   647 a.a.
NCBI ID   WP_014633776.1    Uniprot ID   -
Organism   Streptococcus salivarius JIM8777     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 53885..65828
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SALIVA_RS00310 (SALIVA_0060) argR 54090..54518 (+) 429 WP_171963651.1 arginine repressor -
  SALIVA_RS00315 (SALIVA_0061) - 54518..54877 (+) 360 WP_002889586.1 YlbF family regulator -
  SALIVA_RS00320 (SALIVA_0062) hexA 54897..57428 (+) 2532 WP_371748909.1 DNA mismatch repair protein MutS Machinery gene
  SALIVA_RS00325 (SALIVA_0063) - 57462..57917 (-) 456 WP_014633774.1 DUF3021 domain-containing protein -
  SALIVA_RS00330 (SALIVA_0064) brsR 57914..58351 (-) 438 WP_014633775.1 LytTR family DNA-binding domain-containing protein Regulator
  SALIVA_RS00335 (SALIVA_0065) - 58530..58835 (+) 306 WP_002886319.1 hypothetical protein -
  SALIVA_RS00340 (SALIVA_0066) hexB 58885..60828 (+) 1944 WP_014633776.1 DNA mismatch repair endonuclease MutL Machinery gene
  SALIVA_RS00345 (SALIVA_0067) - 60959..61180 (+) 222 WP_002886321.1 hypothetical protein -
  SALIVA_RS00350 (SALIVA_0068) ruvA 61338..61928 (+) 591 WP_002886323.1 Holliday junction branch migration protein RuvA Machinery gene
  SALIVA_RS00355 (SALIVA_0069) - 61937..62491 (+) 555 WP_002886325.1 DNA-3-methyladenine glycosylase I -
  SALIVA_RS00360 (SALIVA_0070) cinA 62588..63856 (+) 1269 WP_014633777.1 competence/damage-inducible protein A Machinery gene
  SALIVA_RS00365 (SALIVA_0071) recA 63892..65031 (+) 1140 WP_002886327.1 recombinase RecA Machinery gene
  SALIVA_RS00370 (SALIVA_0072) spx 65199..65597 (+) 399 WP_002886328.1 transcriptional regulator Spx -

Sequence

Protein


Download         Length: 647 a.a.        Molecular weight: 72492.58 Da        Isoelectric Point: 5.1368

>NTDB_id=40242 SALIVA_RS00340 WP_014633776.1 58885..60828(+) (hexB) [Streptococcus salivarius JIM8777]
MPKIIELPEVLANQIAAGEVVERPASVVKELVENAIDAGSTQITIEVEESGLSKIQITDNGEGMAQADVAMSLRRHATSK
IKNQGDLFRIRTLGFRGEALPSIASISHLTIVTAADGEAYGTKLVAKGGEIESQDPISTPVGTKITVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLLNDGRQLTQTSGTGDLRQAIAGIYGLTTAKKMVEISNSDLDFEVSGYVSLP
ELTRANRNYITILINGRYIKNFLLNRAIFDGYGSKLMVGRFPIAVIDIQIDPYLADVNVHPTKQEVRISKEKELMALISS
AIAQSLREQDLIPDALENLAKSSTRGAAKPVQTSLPLKQTNLYYDSSRNDFFVKPETVQEDIKPLISESESPVSLVENKP
QPSVKQAQRSADEGDSEQEKLDYKNKSKMKRMLETLDNEETSTFPELEFFGQMHGTYLFAQGQGGLYIIDQHAAQERVKY
EYYREKIGEVDSSLQQLLVPYLFEFSGSDYISLQEKMSLLNQVGIYLEPYGNNTFILREHPIWMKEEEIESAVYEMCDML
LLTNEVSVKTYRAELAIMMSCKRSIKANHALDDYSARDLLVQLAQCKNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHTS
LRDLGKY

Nucleotide


Download         Length: 1944 bp        

>NTDB_id=40242 SALIVA_RS00340 WP_014633776.1 58885..60828(+) (hexB) [Streptococcus salivarius JIM8777]
ATGCCAAAAATCATCGAATTACCTGAGGTGTTAGCCAACCAGATTGCTGCTGGTGAGGTCGTAGAGCGCCCAGCCAGTGT
TGTTAAAGAGTTGGTGGAAAATGCTATTGATGCAGGCAGCACCCAGATTACCATTGAAGTTGAAGAATCAGGCCTCTCAA
AAATTCAAATCACAGATAATGGCGAAGGAATGGCTCAAGCTGATGTGGCCATGAGTTTGCGCCGTCATGCAACAAGTAAA
ATCAAAAATCAAGGAGATCTCTTTCGTATTCGAACCCTTGGTTTTCGAGGTGAGGCCCTACCATCAATAGCTTCTATCAG
CCACCTAACTATTGTGACAGCAGCGGATGGAGAAGCCTATGGGACTAAACTGGTTGCTAAAGGTGGAGAAATTGAGAGTC
AGGACCCTATTTCAACACCAGTTGGAACAAAGATTACCGTTGAAAACCTATTTTATAATACCCCAGCTCGTCTCAAGTAT
ATGAAGAGTTTACAGGCTGAGTTGGCTCATATTGTCGATGTTGTCAATCGTCTGAGTCTAGCTCATCCCGAGGTTGCCTT
TACCTTGCTTAATGATGGTCGTCAGTTGACACAGACATCAGGTACTGGAGACCTCCGTCAAGCTATTGCTGGTATTTATG
GTTTGACAACGGCTAAAAAAATGGTGGAGATTTCAAATTCTGACCTTGATTTTGAAGTTTCTGGATATGTTAGTCTCCCT
GAGTTGACCCGTGCAAATCGTAACTACATCACGATTCTCATTAACGGACGTTATATTAAAAACTTCCTGCTTAACCGTGC
TATTTTTGATGGTTATGGTTCTAAACTCATGGTAGGACGCTTCCCTATTGCGGTTATTGATATTCAGATTGATCCTTATT
TGGCTGATGTCAATGTTCACCCAACCAAGCAGGAAGTACGTATTTCTAAAGAAAAAGAGCTCATGGCCCTTATCAGCTCT
GCCATTGCTCAAAGCCTTAGAGAGCAGGATTTGATTCCTGATGCCCTTGAAAATCTAGCCAAGTCTAGTACCAGAGGTGC
AGCTAAGCCAGTTCAAACCAGTCTTCCACTCAAACAAACCAATCTTTACTATGATAGCAGTCGTAATGATTTCTTTGTCA
AACCAGAGACAGTCCAAGAAGATATCAAACCTCTTATATCGGAGTCAGAGTCTCCAGTTTCATTGGTAGAAAACAAACCG
CAACCTTCTGTTAAACAGGCACAGCGTTCAGCAGATGAAGGTGATAGCGAACAAGAAAAACTTGATTATAAAAACAAGTC
GAAAATGAAGCGCATGCTTGAAACTCTGGACAATGAGGAAACATCAACCTTCCCTGAATTAGAGTTTTTTGGTCAAATGC
ATGGAACCTATCTCTTTGCGCAAGGACAAGGCGGACTTTACATCATTGACCAGCATGCTGCCCAAGAACGTGTCAAGTAT
GAGTACTATCGTGAAAAGATCGGTGAGGTTGACAGCAGTCTACAACAGCTCTTGGTTCCCTATCTCTTTGAATTTTCAGG
TTCAGATTACATTAGTTTACAAGAAAAAATGTCCCTTCTGAACCAGGTTGGTATCTATTTAGAGCCTTATGGGAATAACA
CCTTCATTCTTCGTGAACATCCTATCTGGATGAAGGAAGAAGAGATTGAATCAGCGGTCTATGAAATGTGTGACATGCTT
CTTTTGACGAATGAAGTGTCTGTCAAGACCTACCGTGCTGAGCTAGCCATCATGATGAGTTGTAAACGTTCAATCAAGGC
TAATCATGCACTTGATGATTACTCTGCGCGTGACCTCCTAGTACAGCTTGCACAGTGTAAAAATCCCTACAATTGCCCTC
ACGGACGTCCAGTACTTGTCAACTTTACCAAGTCTGATATGGAAAAAATGTTCCGTCGTATCCAAGAAAATCATACAAGT
CTACGTGACCTAGGGAAGTATTAA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-124)

MutL C terminal dimerisation domain (MutL_C)

(448-591)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

69.846

100

0.702

Multiple sequence alignment