Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   FSA40_RS05240 Genome accession   NZ_CP044493
Coordinates   1038677..1039984 (-) Length   435 a.a.
NCBI ID   WP_002276249.1    Uniprot ID   -
Organism   Streptococcus mutans strain MD     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1033677..1044984
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FSA40_RS05210 (FSA40_1029) - 1034226..1034612 (-) 387 WP_002264513.1 cytidine deaminase -
  FSA40_RS05215 (FSA40_1030) deoC 1034602..1035264 (-) 663 WP_002268748.1 deoxyribose-phosphate aldolase -
  FSA40_RS05220 (FSA40_1032) - 1035283..1036559 (-) 1277 Protein_969 pyrimidine-nucleoside phosphorylase -
  FSA40_RS05225 (FSA40_1033) - 1036668..1037264 (-) 597 WP_002270201.1 class I SAM-dependent methyltransferase -
  FSA40_RS05230 (FSA40_1034) coaA 1037360..1038280 (+) 921 WP_002262217.1 type I pantothenate kinase -
  FSA40_RS05235 (FSA40_1035) rpsT 1038334..1038588 (+) 255 WP_011074586.1 30S ribosomal protein S20 -
  FSA40_RS05240 (FSA40_1036) ciaH 1038677..1039984 (-) 1308 WP_002276249.1 three-component system sensor histidine kinase CiaH Regulator
  FSA40_RS05245 (FSA40_1037) ciaR 1039974..1040648 (-) 675 WP_002262214.1 three-component system response regulator CiaR Regulator
  FSA40_RS05250 (FSA40_1038) - 1040699..1040935 (-) 237 WP_002280153.1 hypothetical protein -
  FSA40_RS05255 (FSA40_1040) - 1041336..1043885 (-) 2550 WP_002280152.1 M1 family metallopeptidase -
  FSA40_RS05260 (FSA40_1041) phoU 1043926..1044579 (-) 654 WP_002262211.1 phosphate signaling complex protein PhoU -

Sequence

Protein


Download         Length: 435 a.a.        Molecular weight: 49868.35 Da        Isoelectric Point: 9.7262

>NTDB_id=390369 FSA40_RS05240 WP_002276249.1 1038677..1039984(-) (ciaH) [Streptococcus mutans strain MD]
MLIKLRKQKQDENISFFSHFFAVFTGIFFVMTVIIIQVMHFGIYSSVDNSLKIATENVNDYVNMTLSHNNPITEAENGDA
SFKVKSNGQMAANTDTILYDKKHNVINNVNAFSSLYHIRPKLKDIGDIVEQEAKNIYGQTEKYRTVTVKVNNDFYPQIKF
ATIVINTTQLEEANTRYVTIIISVMIVFWLISVIASVYLAKWSQKPILENYEKQKSFVENASHELRTPLAVLQNRLESLF
RKPEATILDSSESIASSLEEVRNMRMLTANLLNLARRDDGIKPEITEIQPRFFDDTFKNYEMIARENGKKLHITNKVNRQ
IKTDKTLLKQLMTILFDNAVKYTDNDGEIWLDVKITDRSLIFSVADNGQGISDEDKKKIFDRFYRVDKARTRQKGGFGLG
LSLAKQITDSLKGSIIVKDKKPQGVMFEARLLANK

Nucleotide


Download         Length: 1308 bp        

>NTDB_id=390369 FSA40_RS05240 WP_002276249.1 1038677..1039984(-) (ciaH) [Streptococcus mutans strain MD]
ATGCTAATTAAATTAAGAAAACAAAAGCAGGATGAGAATATTTCATTTTTCAGTCATTTCTTTGCTGTTTTTACCGGAAT
ATTCTTTGTTATGACAGTTATTATTATTCAGGTTATGCATTTTGGTATCTATTCTTCAGTTGATAATAGTCTAAAAATAG
CAACTGAGAATGTCAATGATTATGTCAATATGACTCTATCGCATAATAATCCTATTACTGAAGCTGAAAATGGAGATGCC
TCTTTTAAAGTAAAATCAAATGGCCAGATGGCTGCTAATACAGATACTATTCTTTATGATAAAAAGCATAACGTCATCAA
TAATGTCAATGCCTTCTCTTCTTTGTATCATATTCGCCCTAAACTAAAAGATATTGGTGATATTGTTGAACAAGAAGCTA
AGAATATTTACGGTCAGACCGAAAAGTATCGGACAGTGACAGTTAAGGTAAATAATGATTTTTACCCACAGATAAAATTT
GCAACAATTGTTATTAATACAACACAGCTTGAAGAGGCTAATACGCGTTATGTTACGATTATTATCAGTGTGATGATTGT
TTTTTGGCTTATATCAGTTATTGCCAGTGTTTATTTAGCGAAGTGGAGTCAAAAACCGATTCTGGAAAATTATGAAAAGC
AAAAATCATTTGTTGAAAATGCCAGTCATGAATTACGTACTCCTTTGGCTGTTTTGCAAAATCGCTTGGAGAGTTTGTTT
CGAAAACCAGAGGCTACTATCTTAGATTCTTCGGAATCTATTGCTTCTAGTTTGGAAGAGGTCAGAAACATGAGAATGCT
GACAGCAAATCTCCTTAATTTAGCCCGTCGGGATGATGGTATCAAACCAGAAATAACAGAAATTCAACCTCGTTTTTTTG
ATGATACTTTTAAAAATTATGAGATGATCGCTCGAGAAAATGGGAAAAAATTGCATATTACCAATAAGGTCAACCGTCAA
ATTAAGACAGATAAGACTTTGCTGAAGCAATTAATGACTATTCTTTTTGATAATGCTGTCAAATATACAGATAACGACGG
GGAAATTTGGCTGGACGTCAAGATAACTGATCGCAGTTTAATTTTTTCAGTTGCGGACAATGGTCAAGGTATTTCAGACG
AGGATAAGAAAAAAATTTTTGATCGTTTTTATCGCGTCGATAAAGCCAGAACACGACAAAAGGGTGGGTTCGGACTTGGT
TTGTCTTTGGCAAAACAAATAACAGACAGCTTAAAAGGCAGCATTATTGTTAAAGATAAAAAACCACAAGGAGTAATGTT
TGAAGCTCGCCTGCTTGCTAATAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(215-280)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-431)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

99.54

100

0.995
  ciaH Streptococcus pneumoniae Rx1

55.632

100

0.556
  ciaH Streptococcus pneumoniae D39

55.632

100

0.556
  ciaH Streptococcus pneumoniae R6

55.632

100

0.556
  ciaH Streptococcus pneumoniae TIGR4

55.632

100

0.556

Multiple sequence alignment