Detailed information NTG0387749

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: FOB76_RS04020
• Genome accession: NZ_CP044093
• Coordinates: 754034..754945 (-)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain FDAARGOS_668
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 749034..759945

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOB76_RS04000 (FOB76_04000)	-	750038..751813 (-)	1776	WP_002987732.1	acyltransferase family protein	-
FOB76_RS04005 (FOB76_04005)	-	751810..752211 (-)	402	WP_002987730.1	MORN repeat-containing protein	-
FOB76_RS04010 (FOB76_04010)	-	752235..752672 (-)	438	WP_002987727.1	low molecular weight protein-tyrosine-phosphatase	-
FOB76_RS04015 (FOB76_04015)	ruvB	752810..753808 (-)	999	WP_002987726.1	Holliday junction branch migration DNA helicase RuvB	-
FOB76_RS09760	comS	753855..753950 (-)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
FOB76_RS04020 (FOB76_04020)	comR	754034..754945 (-)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
FOB76_RS04025 (FOB76_04025)	purB	755078..756370 (-)	1293	WP_002987723.1	adenylosuccinate lyase	-
FOB76_RS04030 (FOB76_04030)	-	756739..758079 (-)	1341	WP_002987721.1	hypothetical protein	-
FOB76_RS04035 (FOB76_04035)	purK	758100..759173 (-)	1074	WP_002987718.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
FOB76_RS04040 (FOB76_04040)	purE	759160..759651 (-)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=387749 FOB76_RS04020 WP_002986681.1 754034..754945(-) (comR) [Streptococcus pyogenes strain FDAARGOS_668]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=387749 FOB76_RS04020 WP_002986681.1 754034..754945(-) (comR) [Streptococcus pyogenes strain FDAARGOS_668]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462