Detailed information NTG0378017

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: HB750_RS06785
• Genome accession: NZ_CP050273
• Coordinates: 1383550..1384206 (+)
• Length: 218 a.a.
• NCBI ID: WP_002266318.1
• Uniprot ID: Q9KWH4
• Organism: Streptococcus mutans strain P1
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1378550..1389206

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HB750_RS06755 (HB750_06755)	-	1378784..1379038 (-)	255	WP_002262064.1	DUF3165 family protein	-
HB750_RS06760 (HB750_06760)	typA	1379067..1380911 (-)	1845	WP_002262063.1	translational GTPase TypA	-
HB750_RS06765 (HB750_06765)	-	1381145..1381534 (-)	390	WP_002269630.1	rhodanese-like domain-containing protein	-
HB750_RS06770 (HB750_06770)	-	1381544..1382515 (-)	972	WP_002262061.1	ROK family glucokinase	-
HB750_RS06775 (HB750_06775)	-	1382508..1382714 (-)	207	WP_002262060.1	YqgQ family protein	-
HB750_RS06780 (HB750_06780)	dpr	1382922..1383449 (-)	528	WP_002266317.1	DNA starvation/stationary phase protection protein	-
HB750_RS06785 (HB750_06785)	cclA/cilC	1383550..1384206 (+)	657	WP_002266318.1	prepilin peptidase	Machinery gene
HB750_RS06790 (HB750_06790)	trpA	1384443..1385225 (-)	783	WP_002264437.1	tryptophan synthase subunit alpha	-
HB750_RS06795 (HB750_06795)	trpB	1385229..1386440 (-)	1212	WP_002262056.1	tryptophan synthase subunit beta	-
HB750_RS06800 (HB750_06800)	-	1386437..1387018 (-)	582	WP_002262055.1	phosphoribosylanthranilate isomerase	-
HB750_RS06805 (HB750_06805)	trpC	1387005..1387772 (-)	768	WP_002280743.1	indole-3-glycerol phosphate synthase TrpC	-
HB750_RS06810 (HB750_06810)	trpD	1387765..1388772 (-)	1008	WP_002280744.1	anthranilate phosphoribosyltransferase	-

Sequence

Protein

• Length: 218 a.a.
• Molecular weight: 24893.10 Da
• Isoelectric Point: 8.5763

>NTDB_id=378017 HB750_RS06785 WP_002266318.1 1383550..1384206(+) (cclA/cilC) [Streptococcus mutans strain P1]
MKLILFFMLGASLGSFFGLVVDRYPQKSIIFPRSHCNKCYNCLTMRDLIPIFSRIINKNSCRFCGYPIPLRYSLVELLCG
LISTGFALDLLTTSQVCLLFMGVLLSLYDLQDQSYPLTLWIGFTFLLMFIYPLNLISLILFLFGIFAALKNINIGSGDFF
YLATLALSLNLQQIIWIIQIASLLGILYSLLFQKHKEPFAFVPFLFLGHLIIIFSHLI

Nucleotide

• Length: 657 bp

>NTDB_id=378017 HB750_RS06785 WP_002266318.1 1383550..1384206(+) (cclA/cilC) [Streptococcus mutans strain P1]
ATGAAACTTATTTTATTTTTTATGTTGGGAGCTTCTCTTGGCTCTTTCTTTGGCTTAGTTGTTGATCGTTACCCTCAGAA
ATCTATTATATTTCCTAGAAGCCATTGCAATAAGTGTTATAACTGCTTAACCATGAGGGATCTTATCCCAATATTTTCAC
GAATCATCAACAAAAATTCTTGTCGCTTTTGCGGTTACCCTATTCCATTGCGTTATTCCTTGGTAGAATTACTCTGCGGA
CTGATTAGCACAGGTTTTGCTCTTGATTTATTAACCACTTCACAAGTATGTTTGCTCTTCATGGGAGTTCTTTTATCTCT
TTATGATTTACAAGATCAGTCTTATCCTTTGACACTGTGGATAGGCTTTACTTTTCTCTTAATGTTTATCTATCCTCTTA
ACCTAATTAGCTTAATTCTTTTTCTATTTGGTATTTTTGCTGCCCTCAAAAATATTAATATCGGAAGCGGTGATTTCTTC
TATCTGGCTACTTTGGCACTTTCTCTTAATCTTCAGCAAATTATTTGGATTATTCAGATTGCCAGTTTATTAGGAATTCT
TTACAGCCTGCTTTTTCAAAAGCACAAAGAACCTTTTGCTTTTGTTCCTTTCTTATTCTTGGGTCACCTCATTATCATTT
TCTCTCACTTGATTTAA

Domains

Predicted by InterProScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (9-87)

3D structure

• AlphaFold DB: Q9KWH4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus mitis SK321	42.791	98.624	0.422
cclA/cilC	Streptococcus pneumoniae Rx1	42.254	97.706	0.413
cclA/cilC	Streptococcus pneumoniae D39	42.254	97.706	0.413
cclA/cilC	Streptococcus pneumoniae R6	42.254	97.706	0.413
cclA/cilC	Streptococcus mitis NCTC 12261	41.86	98.624	0.413
cclA/cilC	Streptococcus pneumoniae TIGR4	41.315	97.706	0.404