NTDB

Overview

Name	cclA/cilC	Type	Machinery gene
Locus tag	HB751_RS05400	Genome accession	NZ_CP050272
Coordinates	1109456..1110112 (+)	Length	218 a.a.
NCBI ID	WP_002266318.1	Uniprot ID	Q9KWH4
Organism	Streptococcus mutans strain P6
Function	processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1104456..1115112

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HB751_RS05370 (HB751_05370)	-	1104690..1104944 (-)	255	WP_002262064.1	DUF3165 family protein	-
HB751_RS05375 (HB751_05375)	typA	1104973..1106817 (-)	1845	WP_002262063.1	translational GTPase TypA	-
HB751_RS05380 (HB751_05380)	-	1107051..1107440 (-)	390	WP_002269630.1	rhodanese-like domain-containing protein	-
HB751_RS05385 (HB751_05385)	-	1107450..1108421 (-)	972	WP_002262061.1	ROK family glucokinase	-
HB751_RS05390 (HB751_05390)	-	1108414..1108620 (-)	207	WP_002262060.1	YqgQ family protein	-
HB751_RS05395 (HB751_05395)	dpr	1108828..1109355 (-)	528	WP_002266317.1	DNA starvation/stationary phase protection protein	-
HB751_RS05400 (HB751_05400)	cclA/cilC	1109456..1110112 (+)	657	WP_002266318.1	prepilin peptidase	Machinery gene
HB751_RS05405 (HB751_05405)	trpA	1110349..1111131 (-)	783	WP_002264437.1	tryptophan synthase subunit alpha	-
HB751_RS05410 (HB751_05410)	trpB	1111135..1112346 (-)	1212	WP_002262056.1	tryptophan synthase subunit beta	-
HB751_RS05415 (HB751_05415)	-	1112343..1112924 (-)	582	WP_002262055.1	phosphoribosylanthranilate isomerase	-
HB751_RS05420 (HB751_05420)	trpC	1112911..1113678 (-)	768	WP_002280743.1	indole-3-glycerol phosphate synthase TrpC	-
HB751_RS05425 (HB751_05425)	trpD	1113671..1114678 (-)	1008	WP_002280744.1	anthranilate phosphoribosyltransferase	-

Sequence

Protein

Download Length: 218 a.a. Molecular weight: 24893.10 Da Isoelectric Point: 8.5763

                                >NTDB_id=377869 HB751_RS05400 WP_002266318.1 1109456..1110112(+) (cclA/cilC) [Streptococcus mutans strain P6]

MKLILFFMLGASLGSFFGLVVDRYPQKSIIFPRSHCNKCYNCLTMRDLIPIFSRIINKNSCRFCGYPIPLRYSLVELLCG

LISTGFALDLLTTSQVCLLFMGVLLSLYDLQDQSYPLTLWIGFTFLLMFIYPLNLISLILFLFGIFAALKNINIGSGDFF

YLATLALSLNLQQIIWIIQIASLLGILYSLLFQKHKEPFAFVPFLFLGHLIIIFSHLI

Nucleotide

Download Length: 657 bp

                                >NTDB_id=377869 HB751_RS05400 WP_002266318.1 1109456..1110112(+) (cclA/cilC) [Streptococcus mutans strain P6]

ATGAAACTTATTTTATTTTTTATGTTGGGAGCTTCTCTTGGCTCTTTCTTTGGCTTAGTTGTTGATCGTTACCCTCAGAA

ATCTATTATATTTCCTAGAAGCCATTGCAATAAGTGTTATAACTGCTTAACCATGAGGGATCTTATCCCAATATTTTCAC

GAATCATCAACAAAAATTCTTGTCGCTTTTGCGGTTACCCTATTCCATTGCGTTATTCCTTGGTAGAATTACTCTGCGGA

CTGATTAGCACAGGTTTTGCTCTTGATTTATTAACCACTTCACAAGTATGTTTGCTCTTCATGGGAGTTCTTTTATCTCT

TTATGATTTACAAGATCAGTCTTATCCTTTGACACTGTGGATAGGCTTTACTTTTCTCTTAATGTTTATCTATCCTCTTA

ACCTAATTAGCTTAATTCTTTTTCTATTTGGTATTTTTGCTGCCCTCAAAAATATTAATATCGGAAGCGGTGATTTCTTC

TATCTGGCTACTTTGGCACTTTCTCTTAATCTTCAGCAAATTATTTGGATTATTCAGATTGCCAGTTTATTAGGAATTCT

TTACAGCCTGCTTTTTCAAAAGCACAAAGAACCTTTTGCTTTTGTTCCTTTCTTATTCTTGGGTCACCTCATTATCATTT

TCTCTCACTTGATTTAA

Domains

Predicted by InterProScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(9-87)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q9KWH4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
cclA/cilC	Streptococcus mitis SK321	42.791	98.624	0.422
cclA/cilC	Streptococcus pneumoniae Rx1	42.254	97.706	0.413
cclA/cilC	Streptococcus pneumoniae D39	42.254	97.706	0.413
cclA/cilC	Streptococcus pneumoniae R6	42.254	97.706	0.413
cclA/cilC	Streptococcus mitis NCTC 12261	41.86	98.624	0.413
cclA/cilC	Streptococcus pneumoniae TIGR4	41.315	97.706	0.404

Detailed information NTG0377869