Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   HMPREF0837_RS09755 Genome accession   NC_014251
Coordinates   1864926..1865585 (+) Length   219 a.a.
NCBI ID   WP_000565017.1    Uniprot ID   A0A0E8GKN8
Organism   Streptococcus pneumoniae TCH8431/19A     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1859926..1870585
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF0837_RS09715 (HMPREF0837_12027) mgaSpn 1860082..1861563 (-) 1482 WP_001205280.1 virulence factor transcriptional regulator MgaSpn -
  HMPREF0837_RS09720 (HMPREF0837_12028) - 1862006..1862170 (+) 165 WP_001809002.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  HMPREF0837_RS09725 (HMPREF0837_12029) amaP 1862254..1862820 (+) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  HMPREF0837_RS09730 (HMPREF0837_12030) - 1862832..1863002 (+) 171 WP_000455066.1 DUF2273 domain-containing protein -
  HMPREF0837_RS09735 (HMPREF0837_12031) - 1863041..1863649 (+) 609 WP_000064115.1 Asp23/Gls24 family envelope stress response protein -
  HMPREF0837_RS09740 (HMPREF0837_12032) - 1863680..1863883 (+) 204 WP_000109957.1 CsbD family protein -
  HMPREF0837_RS09745 (HMPREF0837_12033) - 1863993..1864286 (-) 294 WP_307777729.1 transposase -
  HMPREF0837_RS09750 (HMPREF0837_12034) - 1864410..1864856 (-) 447 WP_000155421.1 GNAT family N-acetyltransferase -
  HMPREF0837_RS09755 (HMPREF0837_12035) cclA/cilC 1864926..1865585 (+) 660 WP_000565017.1 A24 family peptidase Machinery gene
  HMPREF0837_RS09760 (HMPREF0837_12036) - 1865637..1866788 (-) 1152 WP_000481747.1 ImmA/IrrE family metallo-endopeptidase -
  HMPREF0837_RS09765 (HMPREF0837_12037) - 1866803..1867534 (-) 732 WP_000934017.1 hypothetical protein -
  HMPREF0837_RS12065 - 1867754..1867864 (+) 111 Protein_1863 prepilin peptidase -
  HMPREF0837_RS09770 (HMPREF0837_12038) trpA 1867836..1868612 (-) 777 WP_001127048.1 tryptophan synthase subunit alpha -
  HMPREF0837_RS09775 (HMPREF0837_12039) trpB 1868605..1869828 (-) 1224 WP_000331287.1 tryptophan synthase subunit beta -
  HMPREF0837_RS09780 (HMPREF0837_12040) - 1869806..1870405 (-) 600 WP_000169885.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24879.99 Da        Isoelectric Point: 7.6418

>NTDB_id=37627 HMPREF0837_RS09755 WP_000565017.1 1864926..1865585(+) (cclA/cilC) [Streptococcus pneumoniae TCH8431/19A]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=37627 HMPREF0837_RS09755 WP_000565017.1 1864926..1865585(+) (cclA/cilC) [Streptococcus pneumoniae TCH8431/19A]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E8GKN8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

96.804

100

0.968
  cclA/cilC Streptococcus pneumoniae Rx1

95.89

100

0.959
  cclA/cilC Streptococcus pneumoniae D39

95.89

100

0.959
  cclA/cilC Streptococcus pneumoniae R6

95.89

100

0.959
  cclA/cilC Streptococcus mitis SK321

92.237

100

0.922
  cclA/cilC Streptococcus mitis NCTC 12261

85.845

100

0.858

Multiple sequence alignment