Detailed information NTG0375091

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: G8B36_RS05645
• Genome accession: NZ_CP049696
• Coordinates: 1119604..1121703 (+)
• Length: 699 a.a.
• NCBI ID: WP_011528518.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain ABC25
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1114604..1126703

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B36_RS05620 (G8B36_05650)	deoD	1114627..1115340 (-)	714	WP_011528521.1	purine-nucleoside phosphorylase	-
G8B36_RS05625 (G8B36_05655)	-	1116003..1116812 (-)	810	WP_011528520.1	purine-nucleoside phosphorylase	-
G8B36_RS05630 (G8B36_05660)	arsC	1116796..1117236 (-)	441	WP_002984932.1	arsenate reductase (glutaredoxin)	-
G8B36_RS05635 (G8B36_05665)	-	1117255..1118466 (-)	1212	WP_011528519.1	phosphopentomutase	-
G8B36_RS05640 (G8B36_05670)	rpiA	1118543..1119226 (-)	684	WP_009881270.1	ribose-5-phosphate isomerase RpiA	-
G8B36_RS05645 (G8B36_05675)	clpC	1119604..1121703 (+)	2100	WP_011528518.1	AAA family ATPase	Regulator
G8B36_RS05650 (G8B36_05680)	-	1121761..1122504 (-)	744	WP_029713994.1	hypothetical protein	-
G8B36_RS05655 (G8B36_05685)	yihA	1122652..1123251 (-)	600	WP_011184414.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
G8B36_RS05660 (G8B36_05690)	clpX	1123261..1124490 (-)	1230	WP_002984948.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
G8B36_RS05665 (G8B36_05695)	-	1124810..1125307 (-)	498	WP_011528516.1	dihydrofolate reductase	-
G8B36_RS05670 (G8B36_05700)	-	1125387..1126226 (-)	840	WP_011017679.1	thymidylate synthase	-

Sequence

Protein

• Length: 699 a.a.
• Molecular weight: 77420.56 Da
• Isoelectric Point: 5.7992

>NTDB_id=375091 G8B36_RS05645 WP_011528518.1 1119604..1121703(+) (clpC) [Streptococcus pyogenes strain ABC25]
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKERQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQTQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSGFNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDA
KAHLIDLGYNRAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ

Nucleotide

• Length: 2100 bp

>NTDB_id=375091 G8B36_RS05645 WP_011528518.1 1119604..1121703(+) (clpC) [Streptococcus pyogenes strain ABC25]
ATGACACATTTTTCTGGTAAAGATCCTTTTGTAAATATGGATGATATTTTCAACCAATTAATGGCAAACATGGGTGGTTA
TCGTAGCGAAAATCCCCGCTATCTCGTTAACGGTCGCGAAATAACTCCCGAAGAATTCCAACACTATCGTCAAACAGGAC
AACTCCCTGTAGCGACAACCAAAGCAACAAATTCTCAAATGTTAACACCTAAAGCTGATAGTGTATTGACTCAACTCGGA
ACTAACTTAACACAAGAAGCTCGTCAAGGGCATCTTGATCCCGTCATCGGTCGTAACAAAGAAATTCAAGATACCGCTGA
AATCTTGGCACGACGAACTAAAAATAATCCTGTCCTTGTCGGAGATGCTGGTGTCGGTAAAACTGCAGTCATTGAAGGTT
TAGCTCAAGCCATTGTTAATGGAGATGTCCCAGCTGCTATTAAAAACAAGGAAATCGTATCAATTGATATTTCTAGTCTT
GAAGCTGGTACACAGTATCGTGGTTCCTTTGAAGAGACCATTCAAAACTTGATTCAAGAAGTAAAAGAAGCTGGGAATAT
CATCTTATTTTTTGATGAAATTCATCAAATAGTTGGTGCTGGTGCCACAAGCAGTGATTCAGGCTCAAAGGGACTTGCAG
ATATTCTTAAACCAGCCTTGTCACGAGGAGAATTAACACTGATTGGTGCTACTACTCAAGACGAATACCGCAATACTATT
TTAAAAAATGCTGCTCTCGCTCGTCGCTTTAATGAAGTTAAAGTGAATGCACCATCAGCTGAAGATACTTTTCACATTTT
AATGGGTATTCGTAATCTTTATGAACAACACCACCATATTACCCTTCCTGATAATGTTCTAAAAGCTGCTGTTGATTATT
CTATTCAATACATCCCACAGCGTAGCCTGCCAGATAAAGCAATTGACTTACTGGATATGACAGCTGCTCATTTAGCTGCG
CAACACCCGGTCACTGACTTAAAAACACTCGAAACTGAAATAGCTAAACAAAAAGAGAGGCAAGAAAAAGCTGTCGCCAA
AGAAGACTTTGAAAAAGCTTTAGCAGCAAAAACACGGATTGAAACATTACAAAAGCAAATTGAGCAACATAACCAAACCC
AAAATGTCACTGCTACAGTCAATGATATCGCAGAGTCTGTAGAGCGCTTAACTGGTATTCCTGTCTCTAACATGGGGACT
AATGATTTAGAAAGGCTCAAAGGAATTAGCAGCCGCTTAAAAAGCCATGTCATCGGACAAGATGAGGCTGTTGCAGCAGT
AGCACGCGCTATTCGACGAAATCGAGCAGGTTTTGATGATGGTAACCGTCCAATAGGTTCTTTCCTTTTTGTGGGTCCAA
CTGGTGTTGGTAAAACAGAGTTAGCTAAACAATTAGCACTTGATTTATTTGGTTCCAAAGATGCTATTATTCGACTTGAT
ATGTCCGAATATAACGATCGCACTGCTGTGTCAAAATTGATTGGGACAACGGCTGGTTATGTTGGCTACGATGATAATAA
TAATACCCTAACTGAGCGTGTTCGTCGTAACCCTTATGCTATTGTCTTACTAGATGAAATTGAAAAAGCTGATCCTCAAA
TCATTACACTTCTTCTACAAGTGTTAGATGATGGACGATTGACAGATGGACAAGGAAATACTATTAACTTTAAAAATACC
GTTATTATTGCTACATCAAATGCCGGTTTTGGCCAACAAGATACGGAAACTTCTGGGTTTAACATTATGGATCGCATTGC
ACCTTATTTCAGACCAGAGTTTTTGAACCGTTTTAATAGTATCATTAAATTTAATCATCTGCAAAAAGAAAATTTAGAAG
AAATTGTTGATTTAATGCTAGCTGAAGTAAATCAAACCACCGCAAAAAAAGGTATTAGTTTAACGATTGCTGATGACGCT
AAAGCTCATTTGATAGATTTAGGGTACAATCGCGCTATGGGAGCTCGTCCATTACGACGTATTATCGAACAGGAAATTCG
TGACCGTATAACTGATTATTATCTTGACCATCCAGAAGTCAAAAAACTTCAGGCAATCCTAAAAGAAGGACAACTAGTGA
TTAGGCAAAACGATCAGTAA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (443-600)

• ATPase family associated with various cellular activities (AAA) (AAA) (118-250)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (607-678)

• AAA lid domain (AAA_lid_9) (259-353)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. cremoris KW2	47.159	100	0.475
clpE	Streptococcus mutans UA159	49.302	92.275	0.455
clpE	Streptococcus pneumoniae TIGR4	50.08	89.413	0.448
clpE	Streptococcus pneumoniae Rx1	50.08	89.413	0.448
clpE	Streptococcus pneumoniae D39	50.08	89.413	0.448
clpE	Streptococcus pneumoniae R6	50.08	89.413	0.448
clpC	Bacillus subtilis subsp. subtilis str. 168	44.511	95.136	0.423
clpC	Streptococcus thermophilus LMD-9	43.103	91.273	0.393
clpC	Streptococcus thermophilus LMG 18311	42.947	91.273	0.392
clpC	Streptococcus pneumoniae Rx1	41.871	93.276	0.391
clpC	Streptococcus pneumoniae D39	41.871	93.276	0.391
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	41.348	93.419	0.386
clpC	Streptococcus pneumoniae TIGR4	42.857	90.129	0.386
clpC	Streptococcus mutans UA159	41.406	91.559	0.379