Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   FPL13_RS06740 Genome accession   NZ_CP041968
Coordinates   1391591..1392892 (-) Length   433 a.a.
NCBI ID   WP_049513573.1    Uniprot ID   A0A7L8W6C4
Organism   Streptococcus sp. KS 6     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1386591..1397892
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FPL13_RS06710 (FPL13_06795) sepM 1386629..1387684 (-) 1056 WP_049512407.1 SepM family pheromone-processing serine protease Regulator
  FPL13_RS06715 (FPL13_06800) coaD 1387665..1388162 (-) 498 WP_049512405.1 pantetheine-phosphate adenylyltransferase -
  FPL13_RS06720 (FPL13_06805) rsmD 1388152..1388700 (-) 549 WP_185952239.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  FPL13_RS06725 (FPL13_06810) - 1389018..1390274 (+) 1257 WP_192208555.1 ISL3 family transposase -
  FPL13_RS06730 (FPL13_06815) hpf 1390310..1390852 (-) 543 WP_049513577.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  FPL13_RS06735 (FPL13_06820) - 1390929..1391594 (-) 666 WP_049513575.1 ComF family protein -
  FPL13_RS06740 (FPL13_06825) comFA/cflA 1391591..1392892 (-) 1302 WP_049513573.1 DEAD/DEAH box helicase Machinery gene
  FPL13_RS06745 (FPL13_06830) - 1392948..1393583 (+) 636 WP_049513571.1 YigZ family protein -
  FPL13_RS06750 (FPL13_06835) cysK 1393682..1394611 (+) 930 WP_049513570.1 cysteine synthase A -
  FPL13_RS06755 (FPL13_06840) cas2 1395993..1396286 (-) 294 WP_049513569.1 CRISPR-associated endonuclease Cas2 -
  FPL13_RS06760 (FPL13_06845) cas1c 1396297..1397322 (-) 1026 WP_048785092.1 type I-C CRISPR-associated endonuclease Cas1c -

Sequence

Protein


Download         Length: 433 a.a.        Molecular weight: 48823.66 Da        Isoelectric Point: 8.8368

>NTDB_id=375018 FPL13_RS06740 WP_049513573.1 1391591..1392892(-) (comFA/cflA) [Streptococcus sp. KS 6]
MTELQDCLGRIFTKSQLSPELQLQAQSLAGMVEEKGKLSCNRCGQAIDKEKQQLPIGAYYCRSCLILGRVRSDEDLYYFP
QEGFPKANVLKWQGKLTAFQAKVSQGLVEAVTKRKDSLVHAVTGAGKTEMIYQVVAQVINQGGAVCLASPRIDVCLELYR
RLKVDFTCDISLLHGESEAYSRSPLVIATTHQLLKFYQAFDLLIVDEVDAFPYVDNPMLYHAVHQAVKVEGTKIFLTATS
TDELDKKVAKGELTRLSLPRRFHGNPLIVPQKIWLVDFQKYLGQKKLVPKLRQFIQKQRKTSFPLLIFASEIKKGQEFAE
ILQSTFPNEKVGFVASTTENRLEIVEKFRQKEITILVTTTILERGVTFPCVDVFVVEANHRLFSRSALVQIAGRVGRSMD
RPTGELLFFHDGTNFAIERAIQEIKAMNQEAGL

Nucleotide


Download         Length: 1302 bp        

>NTDB_id=375018 FPL13_RS06740 WP_049513573.1 1391591..1392892(-) (comFA/cflA) [Streptococcus sp. KS 6]
ATGACGGAATTACAAGATTGCTTAGGTCGTATTTTTACAAAAAGTCAATTGTCACCAGAATTGCAATTGCAAGCACAAAG
CTTAGCTGGAATGGTAGAAGAGAAAGGAAAGTTAAGCTGTAATCGCTGTGGACAAGCCATTGACAAAGAAAAACAGCAAC
TACCAATTGGTGCTTATTATTGTAGGTCTTGCTTGATCTTAGGAAGAGTTAGGAGTGATGAAGATCTCTACTATTTTCCA
CAGGAAGGGTTTCCTAAAGCAAATGTTTTGAAATGGCAAGGAAAGTTGACAGCATTTCAAGCCAAGGTTTCTCAAGGACT
TGTAGAGGCGGTTACCAAACGTAAAGATAGCTTGGTTCACGCAGTCACAGGAGCCGGAAAGACGGAAATGATCTATCAGG
TGGTGGCACAAGTCATCAATCAAGGTGGAGCCGTCTGCTTGGCTAGCCCCAGAATTGATGTCTGCTTAGAACTTTATCGC
AGACTGAAAGTAGATTTTACTTGCGATATTTCACTCCTGCACGGTGAATCAGAAGCATATTCCCGCAGTCCTCTCGTGAT
TGCTACAACGCATCAGCTTCTCAAATTTTATCAAGCCTTTGATCTTCTTATCGTTGATGAAGTAGATGCCTTTCCTTATG
TGGACAATCCGATGCTTTATCATGCGGTTCATCAGGCAGTTAAAGTAGAGGGAACGAAGATTTTCTTAACAGCAACTTCC
ACAGATGAGTTGGATAAAAAAGTGGCTAAAGGAGAATTAACTCGTTTGAGTCTACCTAGACGTTTTCATGGGAATCCTTT
GATTGTTCCTCAAAAAATTTGGTTGGTAGATTTTCAAAAATATCTTGGTCAAAAGAAGCTAGTTCCTAAGTTAAGACAGT
TTATTCAAAAGCAGAGAAAAACAAGCTTTCCACTTCTTATTTTTGCTTCTGAGATTAAAAAGGGGCAAGAATTTGCAGAG
ATTCTTCAAAGCACTTTTCCTAATGAAAAAGTTGGCTTTGTAGCCTCGACGACTGAAAATCGACTAGAAATTGTAGAGAA
ATTTCGTCAAAAAGAAATCACGATTTTGGTGACGACGACGATTTTGGAGCGTGGGGTGACTTTTCCTTGCGTGGATGTTT
TTGTGGTAGAAGCCAATCACCGTCTGTTTAGTCGCAGCGCTCTGGTACAAATCGCTGGACGCGTTGGTCGCAGTATGGAT
CGTCCGACAGGTGAGCTGCTCTTTTTTCATGATGGGACCAATTTTGCTATTGAACGAGCTATTCAGGAAATTAAGGCGAT
GAATCAGGAGGCCGGTTTATGA

Domains

Predicted by InterproScan.

Helicase conserved C-terminal domain (Helicase_C)

(291-397)

DEAD/DEAH box helicase (DEAD)

(108-245)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7L8W6C4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus pneumoniae Rx1

71.963

98.845

0.711
  comFA/cflA Streptococcus pneumoniae D39

71.963

98.845

0.711
  comFA/cflA Streptococcus pneumoniae R6

71.963

98.845

0.711
  comFA/cflA Streptococcus pneumoniae TIGR4

71.729

98.845

0.709
  comFA/cflA Streptococcus mitis NCTC 12261

71.596

98.383

0.704
  comFA/cflA Streptococcus mitis SK321

71.127

98.383

0.7
  comFA Lactococcus lactis subsp. cremoris KW2

55.779

91.917

0.513
  comFA Latilactobacillus sakei subsp. sakei 23K

40.835

99.538

0.406
  comFA Bacillus subtilis subsp. subtilis str. 168

38.765

93.533

0.363

Multiple sequence alignment