Detailed information NTG0375017

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: FPL13_RS06710
• Genome accession: NZ_CP041968
• Coordinates: 1386629..1387684 (-)
• Length: 351 a.a.
• NCBI ID: WP_049512407.1
• Uniprot ID: A0A7L8W760
• Organism: Streptococcus sp. KS 6
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1381629..1392684

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FPL13_RS06685 (FPL13_06770)	cclA/cilC	1381892..1382551 (+)	660	WP_049512414.1	prepilin peptidase	Machinery gene
FPL13_RS06690 (FPL13_06775)	trpB	1382711..1383897 (-)	1187	Protein_1332	tryptophan synthase subunit beta	-
FPL13_RS06695 (FPL13_06780)	-	1384282..1384812 (-)	531	WP_049512413.1	VanZ family protein	-
FPL13_RS06700 (FPL13_06785)	rlmN	1384805..1385887 (-)	1083	WP_049512411.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
FPL13_RS06705 (FPL13_06790)	-	1385926..1386489 (-)	564	WP_049512409.1	YutD family protein	-
FPL13_RS06710 (FPL13_06795)	sepM	1386629..1387684 (-)	1056	WP_049512407.1	SepM family pheromone-processing serine protease	Regulator
FPL13_RS06715 (FPL13_06800)	coaD	1387665..1388162 (-)	498	WP_049512405.1	pantetheine-phosphate adenylyltransferase	-
FPL13_RS06720 (FPL13_06805)	rsmD	1388152..1388700 (-)	549	WP_185952239.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
FPL13_RS06725 (FPL13_06810)	-	1389018..1390274 (+)	1257	WP_192208555.1	ISL3 family transposase	-
FPL13_RS06730 (FPL13_06815)	hpf	1390310..1390852 (-)	543	WP_049513577.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
FPL13_RS06735 (FPL13_06820)	-	1390929..1391594 (-)	666	WP_049513575.1	ComF family protein	-

Sequence

Protein

• Length: 351 a.a.
• Molecular weight: 38352.19 Da
• Isoelectric Point: 10.0691

>NTDB_id=375017 FPL13_RS06710 WP_049512407.1 1386629..1387684(-) (sepM) [Streptococcus sp. KS 6]
MEKPRNKFKKWPIIAIAGLILLFLSFVVPLPYYIEVPGGAADVRQVLRVDNKEDKEKGSYNFVTVGIQHATFAHLVYAWL
TPFTDIYSAKDLTGGTSDKEYMRINQFYMETSQNLAKYQGLKKAGKDITLKYLGVYVLQVTKNSTFKGILNIADTVTGVN
DKTFNSSKELIDYVGAQKIGSKVKVNYVEDGQKKSATGKIIKLENGKNGIGISLIDRTEVTSNTPIEFSTAGIGGPSAGL
MFSLAIYTQIADPTLRDGRNIAGTGSIDREGKVGDIGGIDKKVVSAAKNGAEIFFAPNNPVTKEAKKANPKAKTNYETAL
EAAKKIKTNMKIVPVKTLQDAIDYLKDTKKS

Nucleotide

• Length: 1056 bp

>NTDB_id=375017 FPL13_RS06710 WP_049512407.1 1386629..1387684(-) (sepM) [Streptococcus sp. KS 6]
ATGGAAAAACCAAGAAATAAATTTAAAAAATGGCCGATAATTGCAATAGCAGGGCTGATTTTGCTTTTCTTATCTTTTGT
GGTTCCCTTGCCTTATTATATTGAGGTGCCGGGTGGTGCAGCAGATGTCCGTCAGGTATTGCGCGTGGACAACAAAGAAG
ATAAGGAAAAAGGTTCTTACAACTTTGTAACGGTTGGAATTCAGCATGCGACCTTTGCTCATTTGGTTTATGCTTGGTTG
ACACCTTTTACAGATATTTATTCGGCGAAGGATTTGACTGGCGGAACTTCTGATAAAGAATACATGCGGATCAATCAGTT
TTATATGGAAACATCGCAAAACCTAGCTAAATACCAAGGATTGAAAAAAGCTGGCAAAGATATTACTCTGAAATATCTAG
GGGTTTACGTCTTGCAAGTCACAAAGAATTCTACTTTTAAAGGCATTTTAAATATTGCAGATACCGTGACAGGTGTGAAT
GACAAGACTTTCAATAGTTCAAAAGAATTGATAGACTATGTTGGAGCGCAAAAGATTGGCAGCAAGGTCAAGGTGAACTA
TGTAGAAGATGGTCAGAAGAAATCTGCTACAGGTAAAATCATCAAACTTGAAAATGGGAAAAACGGGATTGGTATTAGCT
TGATCGACCGAACAGAAGTCACAAGCAACACACCAATTGAATTTTCAACAGCCGGTATTGGTGGACCAAGTGCGGGCTTG
ATGTTTAGTTTGGCAATTTATACGCAAATTGCAGATCCAACATTGAGAGACGGTAGAAATATTGCTGGGACAGGCTCAAT
TGACCGCGAAGGAAAAGTTGGCGACATTGGTGGGATTGACAAAAAAGTTGTTTCAGCAGCAAAAAATGGTGCAGAAATTT
TCTTTGCACCAAATAATCCAGTTACTAAGGAAGCTAAAAAAGCTAATCCTAAAGCGAAAACTAACTATGAGACCGCTTTG
GAAGCTGCTAAAAAAATTAAGACCAATATGAAAATTGTACCCGTGAAAACTTTACAAGATGCCATTGATTACCTCAAGGA
CACAAAGAAGTCGTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (133-197)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (234-300)

3D structure

• AlphaFold DB: A0A7L8W760

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	64.244	98.006	0.63