Detailed information NTG0370094

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: GCO85_RS06615
• Genome accession: NZ_CP048618
• Coordinates: 1451230..1451907 (-)
• Length: 225 a.a.
• NCBI ID: WP_011213604.1
• Uniprot ID: -
• Organism: Legionella pneumophila strain ERS1305867
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1446230..1456907

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GCO85_RS06590 (GCO85_06600)	-	1447544..1448287 (+)	744	WP_011213598.1	YebC/PmpR family DNA-binding transcriptional regulator	-
GCO85_RS06595 (GCO85_06605)	ruvC	1448287..1448811 (+)	525	WP_011213599.1	crossover junction endodeoxyribonuclease RuvC	-
GCO85_RS06600 (GCO85_06610)	ruvA	1448808..1449407 (+)	600	WP_011213600.1	Holliday junction branch migration protein RuvA	-
GCO85_RS06605 (GCO85_06615)	-	1449457..1449777 (+)	321	WP_061636956.1	hypothetical protein	-
GCO85_RS06610 (GCO85_06620)	-	1449818..1451233 (-)	1416	WP_011213603.1	ATP-binding protein	-
GCO85_RS06615 (GCO85_06625)	ciaR	1451230..1451907 (-)	678	WP_011213604.1	response regulator	Regulator
GCO85_RS06620 (GCO85_06630)	-	1451968..1452513 (-)	546	WP_011215337.1	septation protein A	-
GCO85_RS06625 (GCO85_06635)	-	1452756..1454195 (-)	1440	WP_061636958.1	LysM peptidoglycan-binding domain-containing protein	-
GCO85_RS06630 (GCO85_06640)	gloB	1454309..1455073 (-)	765	WP_061636963.1	hydroxyacylglutathione hydrolase	-
GCO85_RS06635 (GCO85_06645)	rlmJ	1455077..1455925 (-)	849	WP_061476109.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
GCO85_RS06640 (GCO85_06650)	-	1456211..1456420 (+)	210	WP_011213609.1	hypothetical protein	-

Sequence

Protein

• Length: 225 a.a.
• Molecular weight: 25151.74 Da
• Isoelectric Point: 4.9981

>NTDB_id=370094 GCO85_RS06615 WP_011213604.1 1451230..1451907(-) (ciaR) [Legionella pneumophila strain ERS1305867]
MRLLLVEDDELLGDAVKAGLTQFGYVVDWLKDGEAARAALKSESFELIILDLGLPKLSGLSLLQNIRHDGNSTPVIILTA
RESIEDRVKGLDSGADDYLIKPFDLNELSARIRALVRRSQGRADSVLQYKNITLDPAAHSVFVDDVLVNVPRREFALLQK
LLENSGQVLSREQLMQSIYGWEEDVDSNALEVHIHNLRKKLNANFIRTIRGVGYMAEKNDSVLLS

Nucleotide

• Length: 678 bp

>NTDB_id=370094 GCO85_RS06615 WP_011213604.1 1451230..1451907(-) (ciaR) [Legionella pneumophila strain ERS1305867]
ATGAGATTATTACTTGTTGAAGACGATGAACTGCTTGGCGATGCAGTAAAAGCCGGACTGACACAATTTGGTTACGTTGT
TGACTGGCTAAAAGATGGCGAAGCTGCTCGGGCGGCTCTCAAATCAGAGTCTTTTGAATTAATTATTCTTGACTTGGGAT
TACCTAAATTATCCGGTTTATCATTATTGCAAAACATCAGACATGATGGAAATAGCACACCTGTGATTATTCTTACAGCT
CGAGAATCAATAGAAGATCGGGTAAAAGGCTTAGATAGCGGTGCTGACGATTATCTTATTAAACCTTTTGATTTAAACGA
ATTAAGTGCAAGGATTAGAGCATTGGTAAGGCGCTCTCAGGGCAGAGCTGATTCCGTGTTGCAATATAAAAATATTACTC
TCGATCCTGCTGCTCATTCTGTATTCGTGGATGATGTACTCGTCAATGTTCCAAGAAGAGAATTTGCTTTATTGCAGAAA
TTACTTGAAAACAGTGGCCAGGTTTTATCTCGAGAACAATTAATGCAGAGTATTTATGGCTGGGAAGAAGACGTGGACAG
TAATGCTCTCGAAGTTCATATCCACAATTTACGTAAAAAACTTAACGCAAACTTTATCCGCACTATACGTGGTGTAGGAT
ATATGGCTGAAAAAAATGACAGTGTACTTCTATCGTGA

Domains

Predicted by InterProScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (148-215)

• Response regulator receiver domain (Response_reg) (4-113)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	38.356	97.333	0.373
ciaR	Streptococcus pneumoniae D39	38.356	97.333	0.373
ciaR	Streptococcus pneumoniae R6	38.356	97.333	0.373
ciaR	Streptococcus pneumoniae TIGR4	38.356	97.333	0.373
ciaR	Streptococcus mutans UA159	37.9	97.333	0.369
micA	Streptococcus pneumoniae Cp1015	35.345	100	0.364