Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   SMI_RS02790 Genome accession   NC_013853
Coordinates   494546..495205 (-) Length   219 a.a.
NCBI ID   WP_000564995.1    Uniprot ID   D3H7F6
Organism   Streptococcus mitis B6     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 489546..500205
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS02760 (smi_0542) - 489673..490239 (+) 567 WP_000601934.1 aminodeoxychorismate/anthranilate synthase component II -
  SMI_RS02765 (smi_0543) trpD 490250..491254 (+) 1005 WP_000658706.1 anthranilate phosphoribosyltransferase -
  SMI_RS02770 (smi_0544) trpC 491251..492018 (+) 768 WP_000076515.1 indole-3-glycerol phosphate synthase TrpC -
  SMI_RS02775 (smi_0545) - 492005..492604 (+) 600 WP_000169926.1 phosphoribosylanthranilate isomerase -
  SMI_RS02780 (smi_0546) trpB 492582..493805 (+) 1224 WP_000331302.1 tryptophan synthase subunit beta -
  SMI_RS02785 (smi_0547) trpA 493798..494574 (+) 777 WP_001126991.1 tryptophan synthase subunit alpha -
  SMI_RS02790 (smi_0548) cclA/cilC 494546..495205 (-) 660 WP_000564995.1 prepilin peptidase Machinery gene
  SMI_RS02795 (smi_0549) - 495275..495730 (+) 456 WP_164925545.1 GNAT family N-acetyltransferase -
  SMI_RS11025 - 495764..496015 (+) 252 Protein_508 transposase -
  SMI_RS02800 (smi_0550) - 496152..496355 (-) 204 WP_000109954.1 CsbD family protein -
  SMI_RS02805 (smi_0551) - 496386..496994 (-) 609 WP_000064116.1 Asp23/Gls24 family envelope stress response protein -
  SMI_RS02810 (smi_0552) - 497032..497202 (-) 171 WP_000455065.1 DUF2273 domain-containing protein -
  SMI_RS02815 (smi_0553) amaP 497213..497785 (-) 573 WP_000047597.1 alkaline shock response membrane anchor protein AmaP -
  SMI_RS02820 (smi_0554) - 497862..498098 (-) 237 WP_000964738.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  SMI_RS02825 (smi_0555) mgaSpn 498384..499862 (+) 1479 WP_001205267.1 virulence factor transcriptional regulator MgaSpn -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24923.16 Da        Isoelectric Point: 6.8185

>NTDB_id=36307 SMI_RS02790 WP_000564995.1 494546..495205(-) (cclA/cilC) [Streptococcus mitis B6]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISPASHCDSCQTPLRPLDLIPILSQVLNRFRCRYCKAPYPVWYALFELSLG
LIFLLYFWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWVVFHLLLMVCSDWNLVMVFFLVLGILAHFIDIRMGAGDFL
FLASCALVFSATELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=36307 SMI_RS02790 WP_000564995.1 494546..495205(-) (cclA/cilC) [Streptococcus mitis B6]
ATGATTGATTTTTATTTTTTTCTTGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTCCAGCTAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTGCTCAATCGCTTTCGCTGTCGCTACTGCAAGGCTCCTTATCCTGTCTGGTATGCCCTTTTTGAACTAAGCTTAGGA
CTCATATTTCTGCTTTACTTTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGGTTGTCTTTCATCTGCTTCTAATGGTCTGCTCTGACTGGA
ATCTAGTCATGGTCTTCTTCCTTGTCCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTTCTC
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGTGCGACCGAATTACTCATCTTGATTCAGTTTGCTTCTGCGACGGGAATTCT
AGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTCGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D3H7F6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

91.324

100

0.913
  cclA/cilC Streptococcus pneumoniae D39

91.324

100

0.913
  cclA/cilC Streptococcus pneumoniae R6

91.324

100

0.913
  cclA/cilC Streptococcus mitis SK321

90.868

100

0.909
  cclA/cilC Streptococcus pneumoniae TIGR4

89.041

100

0.89
  cclA/cilC Streptococcus mitis NCTC 12261

84.932

100

0.849

Multiple sequence alignment