Detailed information NTG0036213

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: GALLO_RS10350
• Genome accession: NC_013798
• Coordinates: 2089771..2090502 (-)
• Length: 243 a.a.
• NCBI ID: WP_009855001.1
• Uniprot ID: A0A380K1N3
• Organism: Streptococcus gallolyticus UCN34
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2084771..2095502

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GALLO_RS10310 (GALLO_2008)	comE/comE2	2085548..2086276 (-)	729	WP_012962512.1	LytR/AlgR family response regulator transcription factor	Regulator
GALLO_RS10315 (GALLO_2009)	-	2086375..2086668 (-)	294	WP_009854994.1	bacteriocin immunity protein	-
GALLO_RS10320 (GALLO_2010)	-	2086719..2086946 (-)	228	WP_009854995.1	hypothetical protein	-
GALLO_RS10325 (GALLO_2011)	-	2087216..2087527 (-)	312	WP_003066564.1	bacteriocin immunity protein	-
GALLO_RS10330	-	2087539..2087688 (-)	150	WP_009854997.1	hypothetical protein	-
GALLO_RS10335 (GALLO_2012)	-	2087698..2087997 (-)	300	WP_009854998.1	DUF3884 family protein	-
GALLO_RS10340 (GALLO_2013)	-	2088297..2088434 (+)	138	WP_009854999.1	hypothetical protein	-
GALLO_RS10345 (GALLO_2014)	-	2088456..2089763 (-)	1308	WP_012962514.1	sensor histidine kinase	-
GALLO_RS10350 (GALLO_2015)	comE/comE1	2089771..2090502 (-)	732	WP_009855001.1	response regulator transcription factor	Regulator
GALLO_RS10355 (GALLO_2016)	-	2090519..2090803 (-)	285	WP_231101259.1	LytTR family DNA-binding domain-containing protein	-
GALLO_RS10360 (GALLO_2017)	-	2091046..2091246 (-)	201	WP_009855003.1	hypothetical protein	-
GALLO_RS10370 (GALLO_2018)	-	2091568..2092581 (-)	1014	WP_009855005.1	bacteriocin biosynthesis protein	-
GALLO_RS10375 (GALLO_2020)	-	2093639..2093836 (-)	198	WP_009855009.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
GALLO_RS10380 (GALLO_2021)	-	2093855..2094106 (-)	252	WP_009855010.1	bacteriocin class II family protein	-
GALLO_RS10385 (GALLO_2022)	-	2094353..2094610 (+)	258	WP_009855011.1	hypothetical protein	-

Sequence

Protein

• Length: 243 a.a.
• Molecular weight: 28456.61 Da
• Isoelectric Point: 5.4335

>NTDB_id=36213 GALLO_RS10350 WP_009855001.1 2089771..2090502(-) (comE/comE1) [Streptococcus gallolyticus UCN34]
MLDIYVLEDNIIQQFRMEREIATIMAKNNWDYQRIEVFSSANEIIAKATEKGEHQIFFLDLEIRDDEKQGIDVAKAIREK
DATAIIVFVTTHSEFMLLTYQALVGAIDFIDKNLNDQAFSERIELCLKEAMKHQNDNFGENSFLFETPKARVRMPYSDIL
YFETSPAVHRVIMHTKNDRMEFYATIAEIAKSDKRLFKCHRSFIINVDNVVRFDKATRSVYFETGDTCLVSRDKIKPLLN
EMR

Nucleotide

• Length: 732 bp

>NTDB_id=36213 GALLO_RS10350 WP_009855001.1 2089771..2090502(-) (comE/comE1) [Streptococcus gallolyticus UCN34]
ATGTTAGATATTTATGTACTAGAGGATAATATCATACAGCAATTTCGTATGGAACGCGAGATTGCGACCATTATGGCAAA
AAATAATTGGGACTATCAGAGAATAGAGGTGTTTAGTTCCGCAAATGAGATTATAGCTAAGGCAACTGAAAAAGGAGAGC
ATCAAATTTTCTTTCTTGATTTAGAAATCAGAGACGACGAAAAACAAGGAATTGATGTCGCTAAAGCTATTCGTGAAAAA
GATGCAACAGCTATCATTGTTTTTGTAACAACTCATTCAGAATTTATGCTGCTGACCTACCAAGCGTTAGTAGGGGCAAT
TGATTTTATTGATAAGAACCTGAATGACCAAGCATTTAGTGAACGCATAGAGTTGTGCCTAAAGGAAGCCATGAAACATC
AAAATGATAATTTCGGCGAAAACTCCTTTTTATTTGAAACTCCTAAAGCACGTGTGCGCATGCCATATAGTGACATTCTC
TATTTTGAAACCTCTCCTGCTGTGCACCGCGTGATTATGCATACGAAAAATGACAGAATGGAATTTTATGCAACGATTGC
AGAGATTGCTAAATCAGACAAACGTCTTTTTAAGTGTCATCGTTCTTTTATTATTAATGTGGATAATGTGGTCAGATTTG
ATAAAGCGACACGAAGTGTTTATTTCGAAACTGGGGACACTTGCCTAGTTTCTAGAGATAAAATAAAACCTCTATTAAAT
GAGATGAGGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (11-123)

• LytTr DNA-binding domain (LytTR) (152-238)

3D structure

• AlphaFold DB: A0A380K1N3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	71.605	100	0.716
comE/blpR	Streptococcus mutans UA159	47.699	98.354	0.469
comE/comE2	Streptococcus equinus JB1	46.694	99.588	0.465