Detailed information NTG0036212

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: GALLO_RS10310
• Genome accession: NC_013798
• Coordinates: 2085548..2086276 (-)
• Length: 242 a.a.
• NCBI ID: WP_012962512.1
• Uniprot ID: A0A139R4K2
• Organism: Streptococcus gallolyticus UCN34
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2080548..2091276

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GALLO_RS10285 (GALLO_2005)	rsgA	2080772..2081644 (-)	873	WP_009854990.1	ribosome small subunit-dependent GTPase A	-
GALLO_RS10300	-	2083839..2084039 (-)	201	WP_009854991.1	hypothetical protein	-
GALLO_RS10305 (GALLO_2007)	comD/comD3	2084171..2085535 (-)	1365	WP_012962511.1	GHKL domain-containing protein	Regulator
GALLO_RS10310 (GALLO_2008)	comE/comE2	2085548..2086276 (-)	729	WP_012962512.1	LytR/AlgR family response regulator transcription factor	Regulator
GALLO_RS10315 (GALLO_2009)	-	2086375..2086668 (-)	294	WP_009854994.1	bacteriocin immunity protein	-
GALLO_RS10320 (GALLO_2010)	-	2086719..2086946 (-)	228	WP_009854995.1	hypothetical protein	-
GALLO_RS10325 (GALLO_2011)	-	2087216..2087527 (-)	312	WP_003066564.1	bacteriocin immunity protein	-
GALLO_RS10330	-	2087539..2087688 (-)	150	WP_009854997.1	hypothetical protein	-
GALLO_RS10335 (GALLO_2012)	-	2087698..2087997 (-)	300	WP_009854998.1	DUF3884 family protein	-
GALLO_RS10340 (GALLO_2013)	-	2088297..2088434 (+)	138	WP_009854999.1	hypothetical protein	-
GALLO_RS10345 (GALLO_2014)	-	2088456..2089763 (-)	1308	WP_012962514.1	sensor histidine kinase	-
GALLO_RS10350 (GALLO_2015)	comE/comE1	2089771..2090502 (-)	732	WP_009855001.1	response regulator transcription factor	Regulator
GALLO_RS10355 (GALLO_2016)	-	2090519..2090803 (-)	285	WP_231101259.1	LytTR family DNA-binding domain-containing protein	-
GALLO_RS10360 (GALLO_2017)	-	2091046..2091246 (-)	201	WP_009855003.1	hypothetical protein	-

Sequence

Protein

• Length: 242 a.a.
• Molecular weight: 28063.45 Da
• Isoelectric Point: 6.7499

>NTDB_id=36212 GALLO_RS10310 WP_012962512.1 2085548..2086276(-) (comE/comE2) [Streptococcus gallolyticus UCN34]
MIDIYVLEDDVNQQFRLEKMIDEVLVDNQWQHRCFELFGEPSRLITLIDETVPQIFFLDLDINGDKTKGIEVAKAIRDVS
KTATLVFVTTHSEFMLLTYRAQVSALDFIDKTDSDLAIKENLQACLKKVVEGQVPRLSLDTFIFENNKTKIRIPFEDILY
FETAEAHRLMLVTRTGQRNFYGTIREVKKANHKLFQCHKSYLINPDNVVSLDKKEGLVYFVGGKSCYVSKKHMKELKTKL
ES

Nucleotide

• Length: 729 bp

>NTDB_id=36212 GALLO_RS10310 WP_012962512.1 2085548..2086276(-) (comE/comE2) [Streptococcus gallolyticus UCN34]
ATGATTGATATTTATGTTTTGGAAGATGACGTAAATCAGCAGTTTCGCTTGGAAAAAATGATTGACGAGGTGCTTGTGGA
CAATCAGTGGCAACATCGTTGTTTTGAATTGTTTGGTGAGCCTAGTCGTCTTATCACTCTTATTGATGAAACGGTTCCTC
AAATCTTTTTCTTGGATTTGGATATCAATGGCGATAAAACGAAAGGAATTGAAGTTGCCAAGGCGATTAGAGACGTTTCG
AAAACAGCAACACTTGTCTTTGTTACAACGCATTCTGAATTTATGCTCCTGACCTATCGTGCGCAAGTCAGTGCCCTTGA
TTTCATTGATAAAACCGACAGTGACTTGGCAATCAAGGAAAATTTGCAGGCTTGTTTAAAGAAAGTCGTTGAAGGACAAG
TGCCTCGCCTAAGCTTGGATACCTTTATTTTTGAAAACAATAAAACCAAAATCAGAATACCATTTGAAGATATTCTTTAT
TTTGAAACGGCGGAAGCGCACCGTTTGATGTTGGTGACACGGACAGGACAGCGTAATTTTTACGGAACAATTAGAGAAGT
TAAAAAGGCAAATCATAAGCTATTTCAATGCCATAAATCCTATCTGATTAATCCTGATAATGTCGTCAGTTTGGATAAAA
AAGAAGGGCTTGTTTATTTTGTAGGTGGAAAATCTTGCTACGTTTCCAAAAAACACATGAAAGAATTAAAAACTAAACTA
GAAAGTTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (5-113)

3D structure

• AlphaFold DB: A0A139R4K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus equinus JB1	70.248	100	0.702
comE/comE1	Streptococcus equinus JB1	43.802	100	0.438
comE/blpR	Streptococcus mutans UA159	42.739	99.587	0.426