Detailed information NTG0354589

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SaO217_RS09455
• Genome accession: NZ_CP038461
• Coordinates: 1950423..1951466 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain O217
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1945423..1956466

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SaO217_RS09425 (SaO217_1821)	-	1945844..1947100 (-)	1257	WP_199878552.1	aminopeptidase	-
SaO217_RS09430 (SaO217_1822)	-	1947103..1947303 (-)	201	WP_000180460.1	DUF1128 family protein	-
SaO217_RS09435 (SaO217_1823)	-	1947450..1947914 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
SaO217_RS09440 (SaO217_1824)	-	1947921..1948196 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SaO217_RS09445 (SaO217_1825)	-	1948474..1949691 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
SaO217_RS09450 (SaO217_1826)	vraR	1949804..1950433 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SaO217_RS09455 (SaO217_1827)	vraS	1950423..1951466 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SaO217_RS09460 (SaO217_1828)	liaF	1951463..1952164 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SaO217_RS09465 (SaO217_1829)	-	1952179..1952565 (-)	387	WP_001110178.1	hypothetical protein	-
SaO217_RS09470 (SaO217_1830)	map	1952782..1953540 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SaO217_RS09475 (SaO217_1831)	-	1954177..1955163 (+)	987	WP_001014423.1	FUSC family protein	-
SaO217_RS09480 (SaO217_1832)	-	1955352..1955765 (-)	414	WP_001667305.1	hypothetical protein	-
SaO217_RS09485	-	1955794..1955904 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=354589 SaO217_RS09455 WP_001017131.1 1950423..1951466(-) (vraS) [Staphylococcus aureus strain O217]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=354589 SaO217_RS09455 WP_001017131.1 1950423..1951466(-) (vraS) [Staphylococcus aureus strain O217]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1